Biperiden hydrochloride
- CAS No.
- 1235-82-1
- Chemical Name:
- Biperiden hydrochloride
- Synonyms
- Bicamol;Tasmolin;Akiriden;NSC 84989;NSC 170950;Biperidene HCL;BIPERIDINE HCL;NSC 170950;NSC 84989;akinetonhydrochloride;KL 373 (Hydrochloride)
- CBNumber:
- CB2726050
- Molecular Formula:
- C21H30ClNO
- Molecular Weight:
- 347.92
- MOL File:
- 1235-82-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
| Melting point | 238° |
|---|---|
| storage temp. | 2-8°C |
| solubility | DMSO: >20mg/mL |
| form | powder |
| color | off-white |
| BCS Class | 3/1 |
| NIST Chemistry Reference | Akineton, hydrochloride(1235-82-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P264-P270-P301+P312-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-R22 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | TN3706000 | |||||||||
| Toxicity | LD50 in rats, dogs (mg/kg): 750, 340 orally (Hanna) | |||||||||
| NFPA 704 |
|
Biperiden hydrochloride Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. Biperiden is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy.
Definition
ChEBI: The hydrochloride salt of biperiden. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all forms of Parkinson's disease.
General Description
Biperiden hydrochloride,α-5-norbornen-2-yl- -phenyl-1-piperidinepropanolhydrochloride (Akineton hydrochloride), is a white, opticallyinactive, crystalline, odorless powder that is slightlysoluble in water, ether, alcohol, and chloroform and sparinglysoluble in methanol.
Biological Activity
Muscarinic receptor antagonist that displays some selectivity for the M 1 subtype (K i values are 0.48, 2.4, 3.9, 6.3 and 6.3 nM for M 1 , M 4 , M 3 , M 2 and M 5 receptors respectively). Alleviates extrapyramidal symptoms associated with antipsychotic drugs. Displays antiparkinsonian activity.
Clinical Use
Biperiden hydrochloride has all of the actions describedfor biperiden. The hydrochloride is used for tablets becauseit is better suited to this dosage form than is the lactate salt.As with the free base and the lactate salt, xerostomia (drynessof the mouth) and blurred vision may occur.
Safety Profile
Poison by ingestion andintravenous routes. When heated to decomposition itemits very toxic fumes of NOx and HCl.
Biperiden hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| REAX CHEMICALS | +91-9347443900 +91-9347443900 | Hyderabad, India | 169 | 58 | Inquiry |
| Chemeca Drugs Private Limited (Vegesna Laboratories Pvt Ltd) | +91-8924236065 +91-9951616502 | AndhraPradesh, India | 48 | 58 | Inquiry |
| Lifecare Laboratories Pvt. Ltd | +91-4023750123 +91-4023750123 | Hyderabad, India | 18 | 58 | Inquiry |
| Rivashaa Agrotech Biopharma Pvt. Ltd. | +91-26463395 +91-7926462688 | Gujarat, India | 1615 | 58 | Inquiry |
| Amara Labs Pvt Ltd | +91-9553279972 +91-9100091565 | Hyderabad, India | 42 | 58 | Inquiry |
| Omshri Labs Pvt Ltd | +91-7977270534 +91-9833689647 | Maharashtra, India | 46 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| ProVentus Life Sciences Pvt Ltd | +91-4428362047 +91-4447400141 | Tamil Nadu, India | 20 | 58 | Inquiry |
| Sibram Pharmaceutical | +91-8655777550 +91-8655777550 | Maharashtra, India | 244 | 58 | Inquiry |
| Synnat Pharma Pvt Ltd | +91-9966980001 +91-9989984964 | AndhraPradesh, India | 22 | 58 | Inquiry |
1235-82-1(Biperiden hydrochloride)Related Search:
1of4
chevron_right