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Bipariden

CAS No.: 514-65-8

Chemical Name:: Bipariden

Synonyms: kl373;KL 373;Akineton;biperiden;Beperiden;bipariden;Akinophyl;Bibristan;Biperidine;BiperidenHcl

CBNumber:: CB7501632

Molecular Formula:: C21H29NO

Molecular Weight:: 311.46106

MOL File:: 514-65-8.mol

MSDS File:: SDS

Modify Date:: 2024/10/23 13:36:13

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Bipariden Properties

Melting point	114°C
Boiling point	451.49°C (rough estimate)
Density	1.0202 (rough estimate)
refractive index	1.5614 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly,Sonicated), Methanol (Slightly, Sonicated)
form	Solid
pka	14.05±0.29(Predicted)
color	White to Off-White
Water Solubility	25.1 mg/L
NIST Chemistry Reference	Biperiden(514-65-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Toxicity	LD50 in mice (mg/kg): 195 s.c., 56 i.v. (Klavehn)

Bipariden Chemical Properties,Uses,Production

Uses

amoebicide

Definition

ChEBI: N-Propylpiperidine in which the methyl hydrogens are substituted by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all form of Parkinson's disease.

General Description

Biperiden,α-5-norbornen-2-yl- -phenyl-1-piperidinepropanol (Akineton), introduced in 1959,has a relatively weak visceral anticholinergic, but a strongnicotinolytic, action in terms of its ability to block nicotineinducedconvulsions. Therefore, its neurotropic action israther low on intestinal musculature and blood vessels. It hasa relatively strong musculotropic action, which is aboutequal to that of papaverine, in comparison with most syntheticanticholinergic drugs. Its action on the eye, althoughmydriatic, is much lower than that of atropine. These weakanticholinergic effects add to its usefulness in Parkinson syndromeby minimizing side effects.

Clinical Use

Biperiden is used in all types of Parkinson disease (postencephalitic,idiopathic, arteriosclerotic) and helps toeliminate akinesia, rigidity, and tremor. It is also usedin drug-induced extrapyramidal disorders to eliminatesymptoms and permit continued use of tranquilizers.Biperiden is also of value in spastic disorders not related toparkinsonism, such as multiple sclerosis, spinal cord injury,and cerebral palsy. It is contraindicated in all formsof epilepsy.

Safety Profile

Poison by ingestion,subcutaneous, intraperitoneal, and intravenous routes.When heated to decomposition, it emits toxic fumes ofNOx.

Bipariden Preparation Products And Raw materials

Raw materials

Piperidine hydrochloride Double ring CYCLOHEPTENE Propiophenone 1,3-Cyclopentadiene

Magnesium Hydrochloric acid Acetophenone Formaldehyde

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Preparation Products

Bipariden Suppliers

Global( 99)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
SGMR PHARMACEUTICALS PVT LTD	+91-9032001889 +91-9032001889	Telangana, India	83	58	Inquiry
Dayaram Pharma Chem	+91-9601766800 +91-9601766800	Gujarat, India	61	58	Inquiry
Chempifine Chemicals	+91-2225667766 +91-2225667766	Punjab, India	144	58	Inquiry
Lifecare Laboratories Pvt. Ltd	+91-4023750123 +91-4023750123	Hyderabad, India	18	58	Inquiry
Satya Sree Labs	+91-9963470801 +91-9963470801	Telangana, India	15	58	Inquiry
Maithili Life Sciences Pvt Ltd	+91-9949816141 +91-9963263336	Telangana, India	33	58	Inquiry
Omshri Labs Pvt Ltd	+91-7977270534 +91-9833689647	Maharashtra, India	46	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6100	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry

Supplier	Advantage
SGMR PHARMACEUTICALS PVT LTD	58
Dayaram Pharma Chem	58
Chempifine Chemicals	58
Lifecare Laboratories Pvt. Ltd	58
Satya Sree Labs	58
Maithili Life Sciences Pvt Ltd	58
Omshri Labs Pvt Ltd	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58

514-65-8(Bipariden)Related Search:

Sildenafil Tamsulosin Entacapone Haloperidol 2,2,6,6-Tetramethyl-4-piperidinol

DROPERIDOL Dicyclopentadiene Triacetonediamine Diphenoxylate Biperiden hydrochloride

1-Piperidinepropanol CYCLOHEPTENE 5-Norbornene-2-methanol BIPERIDEN LACTATE cycrimine

Bipariden Biperiden

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alpha-(bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidinopropanol alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropano alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropano alpha-phenyl-alpha-(2-piperidinoethyl)-5-norbornene-2-methano Beperiden -Bicyclo[2,2,1]hept-5-en-2yl-phenyl-1-piperidinepropanol Bicyclo[2.2.1]hept-5-ene-2-methanol, alpha-phenyl-alpha-[2-(1-piperidinyl)ethyl]- biperiden Biperidine KL 373 BIPERIDEN (200 MG) 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-(1-piperidinyl)-1-propanol 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1 1-Piperidinepropanol, alpha-5-norbornen-2-yl-alpha-phenyl- 1-Piperidinepropanol, alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl- 3-Piperidino-1-phenyl-1-bicyclo- 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1) 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol bipariden -5-Norbornen-2-yl-phenyl-1-piperidinepropanol 5-Norbornene-2-methanol, alpha-phenyl-alpha-(2-piperidinoethyl)- a-bicyclo[2.2.1]hept-5-en-2yl-a-phenyl-1-piperidinepropanol Akineton Akinophyl alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol kl373 1-phenyl-3-piperidino-1-(8,9,10-trinorborn-5-en-2-yl)propan-1-ol BiperidenHcl 1-Piperidinepropanol, a-5-norbornen-2-yl-a-phenyl- (6CI, 7CI, 8CI) 1-Piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl- α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidinopropanol α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidine-1-propanol Biperiden, USP Biperiden Hydrochloride USP Biperiden (Mixture of diastereomers) Bibristan 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl- Bipariden USP/EP/BP Alpha-5-Norbornene-2-yl-alphaphentl-1-piperidinepropanol (Biperiden base) Biperiden Hcl -USP/ EP/IP/JP Biperiden (1072001) 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol Bipariden Impurity 514-65-8 C21H29NO