Carbosulfan
- CAS No.
- 55285-14-8
- Chemical Name:
- Carbosulfan
- Synonyms
- Versal;DBSC;BRIGHT;marshall;2,3-Dihydro-2,2-dimethyl-7-benzofuran-N-(2-n-butylaminothio)-N-methylcarbamate;Posse;AMITAGE;MARSHAL;Sheriff;POSSE(R)
- CBNumber:
- CB2739296
- Molecular Formula:
- C20H32N2O3S
- Molecular Weight:
- 380.54
- MOL File:
- 55285-14-8.mol
- Modify Date:
- 2024/7/2 8:55:04
| Melting point | <25 °C |
|---|---|
| Boiling point | approximate 126℃ |
| Density | 1.0560 |
| vapor pressure | 3.1 x 10-5 Pa (20 °C) |
| refractive index | 1.6360 (estimate) |
| Flash point | 96 °C |
| storage temp. | 0-6°C |
| solubility | Chloroform (Slightly), Methanol (Slightly) |
| form | Liquid |
| Water Solubility | 0.3 mg l-1 (25 °C) |
| pka | 3.15±0.70(Predicted) |
| color | Light brown to brown |
| Merck | 13,1836 |
| LogP | 6.050 (est) |
| CAS DataBase Reference | 55285-14-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Carbamic acid, [(dibutylamino)thio]methyl-, 2,3-dihydro-2,2-dimethyl-7-benzofuranyl ester(55285-14-8) |
| EPA Substance Registry System | Carbosulfan (55285-14-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H317-H330-H410 |
| Precautionary statements | P260-P264-P273-P280-P302+P352-P304+P340+P310 |
| Hazard Codes | T;N,N,T,T+ |
| Risk Statements | 23/25-43-50/53-26-25 |
| Safety Statements | 24-37-38-45-60-61-63-36/37-28 |
| RIDADR | UN 2810 |
| WGK Germany | 3 |
| RTECS | EZ3815000 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 in male, female rats (mg/kg): 250, 185 orally; in male, female rabbits (mg/kg): >2000, >2000 dermally; in pheasant, mallard, quail (ppm): 26.2, 8.1, 81.6 orally. LC50 (96 hr) in bluegill, trout (ppb): 14.9, 42.4 (Maitlen). |
Carbosulfan Chemical Properties,Uses,Production
Description
Carbosulfan (8)，2,3-dihydro-2,2-dimethylbenzofuran- 7-yl(dibutylaminothio)methylcarbamate(IUPAC), is an orange to brown, clear viscous liquid (bp 124–128 ?C), miscible with organic solvents and solubility 0.3 ppm in water(25 ?C). It is closely related structurally to carbofuran,and like carbofuran, it is a cholinesterase inhibitor with systemic activity.
Chemical Properties
Orange-yellow thick liquid.
Uses
Carbosulfan is an insecticide with contact and stomach action. It is used to control a wide range of soil-dwelling and foliar pests in cotton, sugar beet, potato, rice, fruit, maize, vegetables, sugar cane and coffee.
General Description
Viscous brown liquid.
Air & Water Reactions
Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids.
Reactivity Profile
Carbosulfan is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.
Potential Exposure
Carbosulfan is a carbamate insecticide and a low toxic derivative from cabofuran. It is a broad spectrum insecticide, nematicide, miticide, effective against pests and mites. It is used to protect alfalfa, apple, citrus, corn, deciduous fruit, potato, rice, sorghum, soybean, sugar beets, sugarcane, and other vegetable, field, tree and orchard crops. It is used for seed treatments
Metabolic pathway
Carbosulfan is an N-sulfenyl-N-methylcarbamate which is effectively a pro-insecticide of carbofuran. The latter is formed in vivo by the biochemical or chemical thiolysis of carbosulfan. N-S Bond cleavage, oxidation, conjugation and hydrolysis are the main metabolic routes for carbosulfan in plants and animals. Carbosulfan is degraded via carbofuran in soil. In plants, carbosulfan is metabolised via carbofuran to 3-hydroxycarbofuran (PM).
Metabolism
Itsmetabolic patterns are similar to those of carbofuran. In rats, it rapidly undergoes hydrolytic and oxidative processes followed by conjugation. It is not persistent in soils, with DT50 ca. 2–5 days, and it was rapidly degraded to carbofuran in a sandy loam soil (4). Carbofuran was subsequently hydrolyzed at the carbamate ester group to form the phenol carbofuran or oxidized at the 3- position. Biscarbofuran disulfide and minor products were also detected. Carbofuran was also formed in soils by nonbiological degradation processes.
Shipping
UN2992 Carbamate pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials; UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Incompatibilities
Carbamates are incompatible with strong oxidizing acids, peroxides, and hydro-peroxides; strong reducing agents such as hydrides; strong acids and bases. Contact with nitrides or chemically active metals (aluminum, copper, magnesium, neptunium, sodium, tin, titanium,zinc, etc.) causes the release of potentially explosive hydrogen gas and a metal salt.
Waste Disposal
Do not discharge into drains or sewers. Dispose of waste material as hazardous waste using a licensed disposal contractor to an approved landfill. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Incineration with effluent gas scrubbing is recommended. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Noncombustible containers should be crushed and buried under more than 40 cm of soil. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
Carbosulfan Preparation Products And Raw materials
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