ChemicalBook > Product Catalog >Organic Chemistry >Organic fluorine compound >Fluoropyridine series >3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

CAS No.: 762240-92-6

Chemical Name:: 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride

Synonyms: Sitagliptin hydrochloride;3-(trifluoromethyl)-5,6,7,8-tetrahydro;Sitagliptin Triazole Hydrochloride;3-(TRIFLUOROMETHYL)-5,6,7,8- TETRAHYDRO[1,2,4]TRIAZOLO[4,3-;3-(Trifluoromethyl)-5;Sitagliptin interMediate A;3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine hydrochloride;3-(Trifluoromethyl)-5 6 7 8-tetrahydro-1 2 4triazolo4 3-apyrazine hydroch;5,6,7,8-Tetrahydro-3-(trifluormethyl)-[4,3-a]-1,2,4-triazolopyrazine hydrochloride;5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 98%

CBNumber:: CB31228965

Molecular Formula:: C6H7F3N4.ClH

Molecular Weight:: 228.6

MOL File:: 762240-92-6.mol

Modify Date:: 2024/5/16 10:38:43

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3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Properties

Melting point	236-246°C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
color	White to Off-White
InChI	InChI=1S/C6H7F3N4.ClH/c7-6(8,9)5-12-11-4-3-10-1-2-13(4)5;/h10H,1-3H2;1H
InChIKey	AQCSCRYRCRORET-UHFFFAOYSA-N
SMILES	C12=NN=C(C(F)(F)F)N1CCNC2.[H]Cl
CAS DataBase Reference	762240-92-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN2811

HS Code

2933599577

NFPA 704

	1
2		0

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TCI Chemicals (India)	T2998	3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride	762240-92-6	1G	₹5200	2022-05-26	Buy
TCI Chemicals (India)	T2998	3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Hydrochloride	762240-92-6	5G	₹16900	2022-05-26	Buy

Product number	Packaging	Price	Buy
T2998	1G	₹5200	Buy
T2998	5G	₹16900	Buy

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Chemical Properties,Uses,Production

Description

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is a pharmaceutical intermediate compound used in the preparation of Sitagliptin phosphate. Sitagliptin is an oral hypoglycaemic agent, a dipeptidyl peptidase-4 inhibitor, which is used in the treatment of type 2 diabetes.

Chemical Properties

White Solid or White to Light yellow powder to crystal

Synthesis

A suspension of N'-[(2Z)-Piperazin-2-ylidene]trifluoroacetohydrazide (27.3 g, 0.13 mol) in 110 mL of methanol was WARMED TO 55 ℃. 37% Hydrochloric acid (11.2 mL, 0.14 mol) was added over 15 min at this temperature. During the addition, all solids dissolved, resulting in a clear solution. The reaction was aged for 30 min. The solution was cooled to 20 ℃ and aged at this temperature until a seed bed formed (10 min to 1 h). 300 ML of MTBE was charged at 20 ℃ over 1 h. The resulting slurry was cooled to 2 ℃, aged for 30 min and filtered. Solids were washed with 50 mL of ethanol: MTBE (1: 3) and dried under vacuum at 45 ℃. Yield of 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride was 26.7 g (99.5 area wt% pure by HPLC).

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Sitagliptin N-Boc IMpurity

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Suppliers

Global( 589)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Kalam Sai Life Sciences Pvt Ltd	+919849478888	Hyderabad, India	73	58	Inquiry
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SURYA LIFE SCIENCES LIMITED	+91-2646226290 +91-9428511112	Gujarat, India	62	58	Inquiry
ALMELO PRIVATE LIMITED	+91-9100991345 +91-8500807769	Telangana, India	114	58	Inquiry
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Supplier	Advantage
Kalam Sai Life Sciences Pvt Ltd	58
Vijayasri Organics Private Limited	58
SURYA LIFE SCIENCES LIMITED	58
ALMELO PRIVATE LIMITED	58
A.R. LIFE SCIENCES PVT. LTD.	58
GSV speciality chemicals	58
Louis Pharmaceuticals Pvt Ltd	58
Dr. Reddy's Laboratories Ltd	58
Molkem Chemicals	58
SRINIVASA LABS	58

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride Spectrum

3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride(762240-92-6)¹HNMR

762240-92-6(3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride)Related Search:

Methyl 3-Oxo-4-(2,4,5-trifluorophenyl)butanoate (+/-)1-(1-Naphthyl)ethylamine Sitagliptin Impurity 27 Benzenebutanoicacid,b-aMino-2,4,5-trifluoro-,Methylester,(bR)- Sitagliptin N-Sulfate

Sitagliptin Defuoro IMpurity 4 Sitagliptin Impurity 26 Meldrum's Acid Fenasi Sitagliptin phosphate

Prazosin 2-Methylpyrazine Terazosin hydrochloride Terazosin Doxazosin

Tetramethylpyrazine Sitagliptin Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)-

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1,2,4-Triazolo[4,3-a]pyrazine,5,6,7,8-tetrahydro-3-(trifluoroMethyl)-,hydrochloride(1:1) 3 - (three fluorinated Methyl) - 5,6,7,8 - four hydrogen - triazole 4-trichlorobenzene [1] and [4, 3 - alpha] pyrazine hydrochloride Sitagliptin side chain 3-CF3-5,6,7,8-H4-[1,2,4]triazolo[4,3a]pyrazine HCl Triazolepine hydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-α]pyrazine Hydrochloride 5,6,7,8-Tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-α]pyrazine Monohydrochloride 5,6,7,8-Tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine Monohydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochlorid 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 3-(trifluoromethyl)-5,6,7,8-retrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo-[4,3-a]pyrazine HCl 3-(TrifluoroMethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyr 5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 3-(trifluoroMethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 5,8-dimethyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine Sitagliptin Intermediate 2 1,2,4-Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-3-(trifluoroMethyl)-, hydrochloride Sitagliptin Impurity 64 Sitagliptin Intermediates Impurity 3-a]pyrazine hydrochloride Sitagliptin Impurity 20 HCl 3-(trifluoromethyl)-5,6,7,8-r Sitagliptin Triazole Impurity HCl Sitagliptin-16 Sitagliptin Triazole (Impurity C) Sitaglliptin phosphate intermediate 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride （Sitagliptin） Sitagliptin triazole impurity hydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo [4,3-a]pyrazine hydrochloride [TTTP] pyrazine HCl Cas762240-92-6 3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine Hydrochloride Sitagliptin Impurity 20 Hydrochloride Urgent? 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride ISO 9001：2015 REACH 3-(trifluoromethyl)-5,6,7, 8-tetrahydro-[1,2,4] triazolio [4,3-a] pyrazine 3-(terifluoromethyl)-7-[(2,4,5-trifluorophenyl]acetyl]-5,6,7,8- tetrahydro[1,2,4]triazole[4,3-a]pyrazine Sitagliptin Triazole HCL 3-trifluoro methyl-[1,2,4]triazole[4,3-a]piperazine hydrochl... 3-(TRIFLUOROMETHYL)-5,6,7,8- TETRAHYDRO[1,2,4]TRIAZOLO[4,3- 3-trifluoro Methyl-[1,2,4]triazole[4,3-a]piperazine hydrochloride Sitagliptin Triazole Hydrochloride 5,6,7,8-Tetrahydro-3-(trifluoromethyl)[1,2,4]triazolo[4,3-a]pyrazine hydrochloride 98% Sitagliptin interMediate A 3-(Trifluoromethyl)-5,6,7,8-tetra-hydro-[1,2,4]-Triazolo-[4,3-a]-pyrazine hydrochloride Salt 5,6,7,8-Tetrahydro-3-(trifluormethyl)-[4,3-a]-1,2,4-triazolopyrazine hydrochloride 3-(Trifluoromethyl)-5 3-(trifluoromethyl)-5,6,7,8-tetrahydro 3-(Trifluoromethyl)-5 6 7 8-tetrahydro-1 2 4triazolo4 3-apyrazine hydroch Sitagliptin hydrochloride 3-(Trifluoromethyl)-5,6,7,8-Tetrahydro-[1,2,4]Triazolo[4,3-A]Pyrazine Hydrochloride / Sitagliptin Intermediate SitagliptinImpurity20-d4 4-(Trifluoromethyl)-5,6,7,8-tetrahydro [1,2,4] Triazolo[4,3-a]pyrazine Hydrochloride 3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride,[1,2,4]Triazolo[4,3-a]Pyrazine Hydrochloride 762240-92-6 Sitagliptin 3-(Trifluoromethyl)-5,6,7,8-tetrahydro- triazolopyrazine Hydrochloride (Triazole) 3-(TRIFLUOROMETHYL)-5,6,7,8-TETRAHYDRO-[1,2,4]TRIZOLO[4,3-A]PYRAZINE HYDROCHLORIDE 3- (Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2.41 triazolo[4,3-a] pyrazine hydrochloride,TRIAZOLE 3-(trifluoromethyl)-5,6,7, 8-tetrahydro-[1,2,4] triazole and [4,3-a] pyrazine hydrochloride