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Brinzolamide-d5

Brinzolamide-d5 Structure
CAS No.
1217651-02-9
Chemical Name:
Brinzolamide-d5
Synonyms
Brinzolamide-d5;[2H5]-Brinzolamide
CBNumber:
CB32507883
Molecular Formula:
C12H21N3O5S3
Molecular Weight:
383.5
MOL File:
1217651-02-9.mol
Modify Date:
2023/6/8 9:03:01
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Brinzolamide-d5 Properties

storage temp. Refrigerator
solubility Ethanol
form Solid
color Crystalline

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
NFPA 704
0
2 0

Brinzolamide-d5 Chemical Properties,Uses,Production

Description

Brinzolamide-d5 is intended for use as an internal standard for the quantification of brinzolamide by GC- or LC-MS. Brinzolamide is a potent inhibitor of carbonic anhydrase II (CAII) and CAIV (IC50s = 3.19 and 45.3 nM, respectively). It is selective for CAII and CAIV over CAI (IC50 = ~1,365 nM). Brinzolamide (30 mg/kg) reduces intestinal charcoal meal progression by 44% and prolongs pentobarbital sodium-induced sleep time by 35% in mice. Topical administration of brinzolamide (0.25, 0.5, and 1 mg/eye) reduces intraocular pressure in a rabbit model of spontaneous ocular hypertension. It also reduces intraocular pressure in a cynomolgus monkey model of argon laser trabeculoplasty-induced ocular hypertension. Formulations containing brinzolamide have been used in the treatment of glaucoma and ocular hypertension.

Chemical Properties

Crystalline Solid

Uses

Carbonic anhydrase inhibitor. Antiglaucoma agent.

Brinzolamide-d5 Preparation Products And Raw materials

Raw materials

Preparation Products

Brinzolamide-d5 Suppliers

Global( 20)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
SynZeal Research Pvt Ltd +1 226-802-2078 Gujarat, India 6522 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Shanghai isotope chemical co.,ltd 021-021-51600108 13062666369 China 4274 58 Inquiry
Cayman Chemical Company (800) 364-9897 United States 6618 81 Inquiry
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627 China 9707 58 Inquiry
Hubei Yangxin Medical Technology Co., Ltd. 15374522761 China 8256 55 Inquiry
Nanjing Shizhou Biology Technology Co.,Ltd 17301488900 China 12582 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
SynZeal Research Pvt Ltd 58
Pharma Affiliates 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
Shanghai isotope chemical co.,ltd 58
Cayman Chemical Company 81
Shanghai EFE Biological Technology Co., Ltd. 58
Hubei Yangxin Medical Technology Co., Ltd. 55
Nanjing Shizhou Biology Technology Co.,Ltd 58

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[2H5]-Brinzolamide Brinzolamide-d5 1217651-02-9 Chiral Reagents Intermediates & Fine Chemicals Isotope Labelled Compounds Pharmaceuticals