3,4-DICHLOROISOCOUMARIN
- CAS No.
- 51050-59-0
- Chemical Name:
- 3,4-DICHLOROISOCOUMARIN
- Synonyms
- 3,4-dci;3,4-DICHLOROISOCOUMARIN;3,4-dichloroisochromen-1-one;3,4-DICHLORO-2-BENZOPYRAN-1-ONE;3,4-dichloro-1H-isochroMen-1-one;1H-2-Benzopyran-1-one, 3,4-dichloro-;3,4-DCI, 3,4-Dichloro-2-benzopyran-1-one;3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem
- CBNumber:
- CB3278415
- Molecular Formula:
- C9H4Cl2O2
- Molecular Weight:
- 215.03
- MOL File:
- 51050-59-0.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:06
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P310-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 25-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | 6.1 | |||||||||
| NFPA 704 |
|
3,4-DICHLOROISOCOUMARIN price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D7910 | 3,4-Dichloroisocoumarin serine protease inhibitor | 51050-59-0 | 5MG | ₹22548.48 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7910 | 3,4-Dichloroisocoumarin serine protease inhibitor | 51050-59-0 | 10MG | ₹33774 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | D7910 | 3,4-Dichloroisocoumarin serine protease inhibitor | 51050-59-0 | 25MG | ₹83330.85 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 287815 | 3,4-Dichloroisocoumarin - CAS 51050-59-0 - Calbiochem | 51050-59-0 | 10MG | ₹21460 | 2022-06-14 | Buy |
3,4-DICHLOROISOCOUMARIN Chemical Properties,Uses,Production
Description
3,4-Dichloroisocoumarin (3,4-DCI) is a serine protease inhibitor. It completely inhibits enzyme activity of 24 serine proteases including human leukocyte elastase, thrombin, plasmin, Factor Xa, and Factor XIIa in vitro. 3,4-DCI stimulates caseinolytic activity of bovine pituitary multicatalytic proteinase complex (MPC) by inducing a conformational change in the MPC that exposes the caseinolytic active site. It has been used to functionally characterize the catalytic activities of multiple proteases including rat liver MPC and extracellular lipase.
Uses
Useful in a rapid staining method for identification of macrophages; counts by this method were confirmed by the more complex morphological criteria, by phagocytosis, and by the presence of Fc receptors. It is an inhibitor of Chymotrypsin and Trypsin. ,4 Dichloroisocoumarin also inhibits granzymes A, B, and H, cathepsin G, neutrophil elastase, proteinase and blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases.
General Description
A potent irreversible inhibitor of serine proteases. Blocks apoptotic internucleosomal DNA cleavage in thymocytes without the involvement of endonucleases. Reacts with serine proteases to release an acylchloride moiety that can acylate another active site residue. Does not affect thiol proteases and metalloproteases. Also has no activity towards β-lactamases. Effective at concentrations ranging from 5-100 μM.
3,4-DICHLOROISOCOUMARIN Preparation Products And Raw materials
Raw materials
Preparation Products
3,4-DICHLOROISOCOUMARIN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32760 | 60 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13141 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| PT CHEM GROUP LIMITED | +86-85511178 +86-85511178 | China | 35451 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| Zhengzhou Lingzhiyue Technology Co., Ltd | +86-0371-55074660 +86-13783527580 | China | 3152 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
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