ChemicalBook > Product Catalog >Biochemical Engineering >Amino Acids and Derivatives >Leucine derivatives >(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE

CAS No.: 66701-25-5

Chemical Name:: (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE

Synonyms: E-64;CS-1623;E-64 HCl;E64;E-64;E 64;E-64 HEMIHYDRATE;E-64 research grade;E-64 solution (10mM);thiolproteaseinhibitor;proteinaseinhibitore64;E-64 PROTEASE INHIBITOR

CBNumber:: CB3667057

Molecular Formula:: C15H27N5O5

Molecular Weight:: 357.41

MOL File:: 66701-25-5.mol

MSDS File:: SDS

Modify Date:: 2024/11/1 18:09:03

Request For Quotation

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Properties

Melting point	>170°C (dec.)
Density	1.44±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	H₂O: 20 mg/mL, clear, colorless
pka	3.16±0.40(Predicted)
form	White solid
color	White or off-white
Water Solubility	Soluble in DMSO (25mg/ml), or water (20mg/ml)
Sensitive	Light Sensitive
BRN	1405664
Stability	Stable for 1 year from date of purchase as supplied.
InChIKey	LTLYEAJONXGNFG-DCAQKATOSA-N
SMILES	O1[C@H](C(N[C@H](C(NCCCCNC(N)=N)=O)CC(C)C)=O)[C@H]1C(O)=O
CAS DataBase Reference	66701-25-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08
Signal word	Warning
Hazard statements	H371
Precautionary statements	P260-P264-P270-P308+P311-P405-P501
Safety Statements	22-24/25
WGK Germany	3
RTECS	RR0390000
F	10
HS Code	29252900

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE price More Price(11)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	E3132	E-64 protease inhibitor	66701-25-5	1MG	₹7252.75	2022-06-14	Buy
Sigma-Aldrich(India)	E3132	E-64 protease inhibitor	66701-25-5	5MG	₹22656.73	2022-06-14	Buy
Sigma-Aldrich(India)	E3132	E-64 protease inhibitor	66701-25-5	10MG	₹36837.48	2022-06-14	Buy
Sigma-Aldrich(India)	E3132	E-64 protease inhibitor	66701-25-5	25MG	₹69388.25	2022-06-14	Buy
Sigma-Aldrich(India)	E3132	E-64 protease inhibitor	66701-25-5	50MG	₹124141.1	2022-06-14	Buy

Product number	Packaging	Price	Buy
E3132	1MG	₹7252.75	Buy
E3132	5MG	₹22656.73	Buy
E3132	10MG	₹36837.48	Buy
E3132	25MG	₹69388.25	Buy
E3132	50MG	₹124141.1	Buy

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Chemical Properties,Uses,Production

Uses

It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained

General Description

E-64 is a cysteine protease inhibitor that was isolated from the mold Aspergillus japonicus TPR-64. E-64 is also known as N-[N-(L-3-trans-carboxyoxiran-2-carbonyl)-L-leucyl]-agmatine. E-64 effectively inhibits various cysteine proteases, in particular:

cathepsin K
cathepsin L
cathepsin S

E-64 also acts against other enzymes, such as:

calpain
cathepsin B
cathepsin H
papain

Hazard

A reproductive hazard.

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Preparation Products And Raw materials

Raw materials

Preparation Products

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Suppliers

Global( 224)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5870	58	Inquiry
Alfa Aesar	1 800 209 7001	Maharashtra, India	6905	58	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32820	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32038	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30241	58	Inquiry
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	China	23541	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	23325	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Otto Chemie Pvt. Ltd.	58
Alfa Aesar	58
Alpha Biopharmaceuticals Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE Spectrum

(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE(66701-25-5)¹HNMR

66701-25-5((L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE)Related Search:

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Pepstatin Trametinib 4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride Z-VAD-FMK TRANS-2,3-EPOXYBUTANE

(R)-(-)-AMINO-3-HYDROXYBUTANOIC ACID GLYCIDAMIDE (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE 2-Hydroxy-4-amino butanoic acid (2-amino-2-oxoethoxy)acetic acid

2(2-HYDROXYETHOXY)ACETAMIDE (2-AMINO-ETHOXY)-ACETIC ACID EP 459

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(2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxylic acid (2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carb oxiranecarboxylicacid,3-(((1-(((4-((aminoiminomethyl)amino)butyl)amino)carbon proteinaseinhibitore64 thiolproteaseinhibitor TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-*(4-GU ANIDINO)BUT (2S, 3S)-TRANS-EPOXY SUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO) BUTANE L-TRANS-3-CARBOXYOXIRAN-2-CARBONYL-L-LEUCYLAGMATINE L-TRANS-EPOXYSUCCINYL-LEU-4-GUANIDINOBUTYLAMIDE L-TRANS-EPOXYSUCCINYL-LEU-AGMATINE (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE (E-64) E-64, L-trans-Epoxysuccinyl-Leu-agMatine 2-Oxiranecarboxylic acid, 3-[[[(1S)-1-[[[4-[(aMinoiMinoMethyl)aMino]butyl]aMino]carbonyl]-3-Methylbutyl]aMino]carbonyl]-, (2S,3S)- L-TRANS-EPOXYSUCCINYL-LEUCYLAMIDE-(4-GUANIDO)-BUTANE TRANS-EPOXYSUCCINYL-LEUCYLAMIDO-[4-GUANIDINO]BUTANE TRANS-EPOXYSUCCINYL-L-LEUCYL-AMIDO(4-GUANDINO)BUTANE TRANS-EPOXYSUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO)BUTANE TRANS-3-CARBOXYOXIRANE-2-CARBONYL-L-LEUCYLAGMATINE (2s-(2-alpha,3-beta(r*)))-yl)-3-methylbutyl)amino)carbonyl) e64(proteinaseinhibitor) 3-[[[(1S)-1-[[[4-[(aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-(2S,3S)-oxiranecarboxylic acid trans-Epoxysuccinyl-L-leucylaMido(4-guanidino)butane, L-trans-3-Carboxyoxiran-2-carbonyl-L-leucylagMatine, N-(trans-Epoxysuccinyl)-L-leucine 4-guanidinobutylaMide (2S,3S)-3-(((S)-1-((4-Guanidinobutyl)amino)-4-methyl-1-oxopentan-2-yl)carbamoyl)oxirane-2-carboxy EPOXYSUCCINYL-L-LEUCYLAMIDO-(4-GUANIDINO)BUTANE E-64 HEMIHYDRATE E-64 PROTEASE INHIBITOR EXPOXY[L-3-TRANS-CARBOXYOXIRAN-2-CARBONYL]-L-LEU-AGMATIN [L-3-TRANS-CARBOXY-OXIRAN-2-CARBONYL]-LEU-AGMATIN (L-3-TRANS-CARBOXYOXIRAN-2-CARBONYL)-L-LEUCYL-AGMATIN (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYL-AGMATINE (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE N-(TRANS-EPOXYSUCCINYL)-L-LEUCINE 4-GUANIDINOBUTYLAMIDE N-[N-(L-3-TRANS-CARBOXIRANE-2-CARBONYL)-L-LEUCYL]-AGMATINE N-[N-(L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL]-L-LEUCYL)-AGMATINE E-64 research grade CS-1623 E64;E-64;E 64 E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem (2S,3S)-3-[[[(1S)-1-[[[4-(Aminoiminomethyl)amino]butyl]amino]carbonyl]-3-methylbutyl]amino]carbonyl]-2-oxiranecarboxylic acid (L-3-TRANS-CARBOXYOXIRANE-2-CARBONYL)-L-LEUCYLAGMATINE HEMIHYDRATE USP/EP/BP E-64 HCl 3-[[1-[4-(diaminomethylideneamino)butylamino]-4-methyl-1-oxopentan-2-yl]carbamoyl]oxirane-2-carboxylic acid E-64 Cathepsin,Inhibitor,Proteinase inhibitor E-64,inhibit,Proteinase inhibitor E64,E-64,Bacterial,Autophagy E-64 solution (10mM) 66701-25-5 C15H27N5O5 Biochemicals and Reagents BioChemical A to C Organic Covalent Modifiers Enzyme Inhibitors Enzyme Inhibitors by Type Enzyme Inhibitors by Enzyme Enzymes, Inhibitors, and Substrates Pepetides ProteaseInhibitors Inhibitors