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Pepstatin

CAS No.: 26305-03-3

Chemical Name:: Pepstatin

Synonyms: PEPSTATIN A;(3S,4S)-4-AMINO-3-HYDROXY-6-METHYL-HEPTANOIC ACID;CPSD;PEPSTATIN;PepstainA;ahpatininc;procidins735a;A Pepstatin A;Pepstatin A TFA;PEPSTATIN A 10MG

CBNumber:: CB5155004

Molecular Formula:: C34H63N5O9

Molecular Weight:: 685.89

MOL File:: 26305-03-3.mol

MSDS File:: SDS

Modify Date:: 2024/7/19 18:29:52

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Pepstatin Properties

Melting point	233 °C (dec.)(lit.)
alpha	D27 -90.3° (c = 0.288 in methanol)
Boiling point	695.91°C (rough estimate)
Density	1.1340 (rough estimate)
refractive index	1.7500 (estimate)
storage temp.	2-8°C
solubility	10% acetic acid in methanol: 1 mg/mL
pka	4.17±0.10(Predicted)
form	White solid
color	Colorless needles
optical activity	Optical rotation: -90.0 ± 5° (c = 0.5, MeOH, 20°C).
Water Solubility	It is soluble in 10% (v/v) acetic acid in methanol (9:1 methanol:acetic acid) (1 mg/ml), ethanol (1-2 mg/ml with heat up to 60°C), DMSO (5 mg/ml), methanol (1 mg/ml), and acetic acid. Insoluble in benzene, chloroform, water, 1 M NaOH, and ether.
BRN	2201362
Stability	Stable. Incompatible with strong bases, strong acids.
InChIKey	JKGWASGTXVCDML-LXTPJMTPSA-N
CAS DataBase Reference	26305-03-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P305+P351+P338
Safety Statements	22-24/25
WGK Germany	2
RTECS	SC6155000
F	10
HS Code	29241990
Toxicity	LD50 in mice, rats, rabbits, dogs (mg/kg): 1090, 875, 820, 450 i.p.; all >2000 orally (Umezawa, 1970)

Pepstatin price More Price(19)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	P4265	Pepstatin A microbial, ≥75% (HPLC)	26305-03-3	1MG	₹4282.2	2022-06-14	Buy
Sigma-Aldrich(India)	P5318	Pepstatin A microbial, ≥90% (HPLC)	26305-03-3	5MG	₹9136.3	2022-06-14	Buy
Sigma-Aldrich(India)	P4265	Pepstatin A microbial, ≥75% (HPLC)	26305-03-3	5MG	₹9796.6	2022-06-14	Buy
Sigma-Aldrich(India)	SAB4500553	Anti-CATD (light chain, Cleaved-Gly65) antibody produced in rabbit affinity isolated antibody	26305-03-3	100μG	₹50560.5	2022-06-14	Buy
Sigma-Aldrich(India)	P4265	Pepstatin A microbial, ≥75% (HPLC)	26305-03-3	25MG	₹26986.4	2022-06-14	Buy

Product number	Packaging	Price	Buy
P4265	1MG	₹4282.2	Buy
P5318	5MG	₹9136.3	Buy
P4265	5MG	₹9796.6	Buy
SAB4500553	100μG	₹50560.5	Buy
P4265	25MG	₹26986.4	Buy

Pepstatin Chemical Properties,Uses,Production

Description

Pepstatin A is a bacterial-derived chemotactic pentapeptide that irreversibly inhibits aspartic proteases, including pepsin, gastricsin, renin, cathepsin E, and cathepsin D. Pepstatin A has been reported to stimulate human neutrophil degranulation (EC₅₀ = 0.75 μM) and super oxide production (EC₅₀ = 1.5 μM). Pepstatin A has been widely used as a research tool in studies of protease mechanisms and biological functions and has been examined as a therapeutic agent for inflammatory conditions including gastric ulcer, edema, and hypertension.

Chemical Properties

solid

Uses

Pepstatin A are natural, statine-containing peptides that acts as inhibitor of aspartic protease enzymes.

General Description

Pepstatin A is a naturally occurring chemotactic peptide and inhibitor of aspartic proteases that was initially isolated from culture filtrates of various Actinomycetes species, with the initial name simply of “pepstatin”. This name was later modified to “pepstatin A” to distinguish the original pepstatin from later derivatives. Pepstatin A notably contains the unusual amino acid 4-amino-hydroxy-6-methylheptanoic acid (AHMHA), which is known also as statine. The amino acid sequence of pepstatin A is N-Isovaleryl-L-Valyl-L-Valyl-AHMHA-L-Alanyl-AHMHA.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

Enzyme inhibitor

This naturally occurring statine-containing peptidomimetic (FWfree-acid = 685.90 g/mol; CAS 26305-03-3), also called pepstatin A and isovalerylpepstatin and named systematically as N-(isovaleryl)-L-valyl-L-valyl-statylL-alanyl-statine (where the statyl residue is a (3S,4S)-4-amino-3-hydroxy-6- methylheptanoyl residue and the C-terminal statine is the corresponding acid), is a presumptive transition-state analogue for prototypical aspartate proteinase pepsin (Ki = 46 pM). Pepstatin will also inhibit other carboxy proteinases. The inhibitory effectiveness of statine-containing peptides has been widely exploited by incorporating the statine residue into peptides that otherwise match sequence preferences of the target enzyme’s sub-sites. Because pepstatin has a low solubility in water, it is often dissolved indimethyl sulfoxide, methanol, or ethanol. Note that many derivatives of pepstatin are available, each displaying a different spectrum of inhibitory effects. Pepstatin B and C are the N-(n-caproyl)- and N-(iso-caproyl)- derivatives, respectively. Note: Above a critical concentration of 0.1 mM in low ionic-strength and neutral buffers, pepstatin often polymerizes into filaments that be several micrometers in length and have characteristic diameters ranging between 6 and 12 nm

Pepstatin Preparation Products And Raw materials

Raw materials

FMOC-Ala-OH FMOC-STA-OH FMOC-L-Valine Isovaleric acid

Preparation Products

Pepstatin Suppliers

Global( 297)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5873	58	Inquiry
Apeloa production Co.,Limited	+8619933239880	China	853	58	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29898	58	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10318	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry

Supplier	Advantage
CHEMSWORTH	30
A.J Chemicals	58
Otto Chemie Pvt. Ltd.	58
Apeloa production Co.,Limited	58
Alpha Biopharmaceuticals Co., Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58

Pepstatin Spectrum

Pepstatin(26305-03-3)MS Pepstatin(26305-03-3)Raman Pepstatin(26305-03-3)FT-IR

26305-03-3(Pepstatin)Related Search:

Kresoxim-methyl Basic Violet 1 Trypsin inhibitor CHLOROPHOSPHONAZO III Pepsin

Methyl acrylate Methylparaben Leupeptin Aprotinin Methanol

Acetonitrile Paraquat dichloride Methyl Saccharated Pepsin DL-4-Amino-3-hydroxybutyric acid

(S)-(+)-4-AMINO-3-HYDROXYBUTANOIC ACID ACETYL-PEPSTATIN,AC-PEPSTATIN,PEPSTATIN, ACETYL- PEPSTATIN A METHYL ESTER

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ahpatininc pepsininhibitors735a procidins735a PEPSTATIN X-VAL-VAL-STATYL-ALA-STATIN AHMHA ISOVALERYL-L-VAL-L-VAL-AHMHA-L-ALA-STA Pepstatin A, Ultra Pure pepstatin|Pep A|PEP|peptistatin A|pepstatine A|Pepstatin A|pepstatine pepstatin|Pepstatin A Pepstatin A Microbial N-(3-methyl-1-oxobutyl)-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-[(1S)-1-[(1S)-2-carboxy-1-hydroxyethyl]-3-methylbutyl]-L-alaninamide Anti-CATD (light chain, Cleaved-Gly65) antibody produced in rabbit Cathepsin D heavy chain Cathepsin D light chain CPSD Anti-CATD (heavy chain, Cleaved-Leu169) antibody produced in rabbit EZNA KIT MICROELUTE VIRAL DNA/RNA SUCROSE PROTEOMICS GRADE I-VALERYL-L-VAL-L-VAL-AHMHA-L-ALA-AHMHA IVA-VAL-VAL-STA-ALA-STA ISOVALERYL-VAL-VAL-4-AMINO-3-HYDROXY-6-METHYLHEPTANOYL-ALA-4-AMINO-3-HYDROXY-6-METHYLHEPTANOIC ACID ISOVALERYL-VAL-VAL-STA-ALA-STA ISOVALERYL-VAL-VAL-STA-ALA-STA-OH ISOVALERYL-VAL-VAL-STA-ALA-STA-OH (MICROBIAL PRODUCT) ISOVALERYL-L-VAL-L-VAL-AHMHA-L-ALA-AHMHA STA ISO-VALERYL-L-VAL-L-VAL-STA-L-ALA-STA ISOVALERYL-L-VAL-L-VAL-STATINYL-L-ALA-STATINE ISOVALERYL-L-VALYL-L-VALYL-[(3S,4S)-4-AMINO-3-HYDROXY-6-METHYLHEPTANOYL]-L-ALANYL[(3S,4S)-4-AMINO-3-HYDROXY-6-METHYLHEPTANOIC ACID] ISOVALERYL-L-VALYL-L-VALYL-4-AMINO-3-HYDROXY-6-METHYLHEPTANOYL-L-ALANYL-4-AMINO-3-HYDROXY-6-METHYLHEPTANOIC ACID ISOVAL-VAL-VAL-4-AMINO-3-HYDROXY-5-METHYLHEPTANOYL-ALA-4-AMINO-3-HYDROXY-6-METHYLHEPTANOIC ACID ISOVAL-VAL-VAL-STA-ALA-STA Pepstatin (microbial product) pepstatin A ~120'000 U/mg pepstatin A from microbial source PEPSTATIN A SYNTHETIC PEPSTATIN ULTRA PURE GRADE (3S,4S)-3-Hydroxy-4-[[(2S)-2-[[(3S,4S)-3-hydroxy-6-methyl-4-[[(2S)-3-methyl-2-[[(2S)-3-methyl-2-(3-methylbutanoylamino)butanoyl]amino]butanoyl]amino]heptanoyl]amino]propanoyl]amino]-6-methylheptanoic acid N-Isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-gamma-aminoheptanoyl-L-alanyl-3-hydroxy-6-methyl-gamma-aminoheptanoic acid N-Isovaleryl-L-valyl-L-valyl-3-hydroxy-6-methyl-g-aminoheptanoyl-L-alanyl-3-hydroxy-6-methyl-g-aminoheptanoic acid (3S,4S)-4-[N-[(3S,4S)-4-[N-[N-(3-Methyl-1-oxobutyl)-L-valyl]-L-valylamino]-3-hydroxy-6-methylheptanoyl]-L-alanylamino]-3-hydroxy-6-methylheptanoic acid Isovalerylpepstatin N-Isovaleryl-L-Val-L-Val-[(3S,4S)-3-hydroxy-4-amino*-6-methylheptanoyl]-L-Ala-[(3S,4S)-3-hydroxy-4-amino*-6-methylheptanoyl]-OH L-Alaninamide, N-(3-methyl-1-oxobutyl)-L-valyl-L-valyl-(3S,4S)-4-amino-3-hydroxy-6-methylheptanoyl-N-(1S)-1-(1S)-2-carboxy-1-hydroxyethyl-3-methylbutyl- PepstainA A Pepstatin A Pepstatin, ≥98% (HPLC) InSolution Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem Pepstatin A, Synthetic - CAS 26305-03-3 - Calbiochem PEPSTATIN A 10MG Pepstatin USP/EP/BP 3-Trilinoleoylglycerol PEPSTATIN A (3S,4S)-4-AMINO-3-HYDROXY-6-METHYL-HEPTANOIC ACID (6S,9S,12S,13S,17S,20S,21S)-13,21-Dihydroxy-12,20-diisobutyl-6,9-diisopropyl-2,17-dimethyl-4,7,10,15,18-pentaoxo-5,8,11,16,19-pentaazatricosan-23-oic acid Pepstatin A >95% Pepstatin A TFA 26305-03-3 26175-03-3