Protocatechuic acid
- CAS No.
- 99-50-3
- Chemical Name:
- Protocatechuic acid
- Synonyms
- 3,4-DIHYDROXYBENZOIC ACID;protocatechuate;3,4-Dihydroxybenzoic;Protocatechuic aci;Protocatechoic Acid;PROTOCATECHUIC ACID(P);3,4-Dihydroxybenzoic acid,97%;Pyrocatechol-p-carboxylic acid;3,4- twohydroxybenzoic acid/protocatechuicacid;3,4-Dihydroxybenzoic acid Vetec(TM) reagent grade, 97%
- CBNumber:
- CB3305861
- Molecular Formula:
- C7H6O4
- Molecular Weight:
- 154.12
- MOL File:
- 99-50-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/12/18 14:08:52
| Melting point | 197-200 °C (dec.) (lit.) |
|---|---|
| Boiling point | 237.46°C (rough estimate) |
| Density | 1.54 |
| refractive index | 1.6400 (estimate) |
| FEMA | 4430 | 3,4-DIHYDROXYBENZOIC ACID |
| storage temp. | Store below +30°C. |
| solubility | 20g/l |
| pka | 4.48(at 25℃) |
| form | Fine Crystalline Powder |
| color | Beige to brown |
| PH | 3.78(1 mM solution);3.25(10 mM solution);2.74(100 mM solution) |
| Odor | at 100.00 %. mild phenolic balsamic |
| Odor Type | phenolic |
| Water Solubility | Soluble in hot alcohol and ether. Slightly soluble in water. |
| Sensitive | Air Sensitive |
| Merck | 14,7894 |
| BRN | 1448841 |
| Stability | Stable. Incompatible with strong oxidizing agents, strong bases. |
| InChIKey | YQUVCSBJEUQKSH-UHFFFAOYSA-N |
| LogP | 1.16 |
| CAS DataBase Reference | 99-50-3(CAS DataBase Reference) |
| EPA Substance Registry System | Protocatechuic acid (99-50-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UL0560000 | |||||||||
| HS Code | 29182990 | |||||||||
| NFPA 704 |
|
Protocatechuic acid price More Price(9)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 37580 | 3,4-Dihydroxybenzoic acid ≥97.0% (T) | 99-50-3 | 25G | ₹5693.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 37580 | 3,4-Dihydroxybenzoic acid ≥97.0% (T) | 99-50-3 | 100G | ₹14862.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 08992 | 3,4-Dihydroxybenzoic acid analytical standard | 99-50-3 | 50MG | ₹9731.68 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C0055 | 3,4-Dihydroxybenzoic Acid | 99-50-3 | 25G | ₹5300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0055 | 3,4-Dihydroxybenzoic Acid | 99-50-3 | 100G | ₹8600 | 2022-05-26 | Buy |
Protocatechuic acid Chemical Properties,Uses,Production
Chemical Properties
white to light yellow crystal powder
Uses
3,4-Dihydroxybenzoic Acid is a metabolite of polyphenols such as Phloretin (P339000) and Quercetin (Q509500).
Definition
ChEBI: A dihydroxybenzoic acid in which the hydroxy groups are located at positions 3 and 4.
Biosynthesis
Protocatechuic acid is synthesized from the intermediates of the shikimate pathway. In this case, 3-dehydroshikimate is converted to protocatechuic acid as shown in Fig.11.2. Activity measurements from mung bean seedlings, on the other hand, indicate that 3-dehydroshikimate can be converted to protocatechuic acid (Widhalm and Dudareva 2015). Protocatechuic acid (11.12) upon hydroxylation produces gal- lic acid. The enzyme catalyzing this reaction is not well understood (Muir et al.2011).
Biosynthesis of Protocatechuic Acid
General Description
Protocatechuic acid belongs to the class of polyphenolic compounds, which can be generally isolated from the dried flower of roselle. It can serve as a potential candidate possessing anticancer property, which can be involved in suppressing the growth of human promyelocytic leukemia HL-60 cells.
Biological Activity
Protocatechuic acid (PCA) is a dihydroxybenzoic acid phenolic compound found in many edible and medicinal plants. It is a major metabolite of antioxidant polyphenols found in green tea and demonstrates free radical scavenging capability in a 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity assay (IC50 = 16.3 μM). It is thought to possess anti-inflammatory, antihyperglycemic, neuroprotective, and anticancer activities. Dietary administration of PCA dose dependently inhibits in vitro chemical carcinogenesis and exerts pro-apoptotic and anti-proliferative effects in different tissues. In studies of tumor cell migration and invasion using mouse melanoma B16/F10 cells, PCA at 0.1-2 mM down-regulated the Ras/Akt/NF-κB pathway by targeting RhoB activation, leading to a reduction of MMP-mediated activity.
Protocatechuic acid Preparation Products And Raw materials
Raw materials
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|---|---|---|---|---|---|
| BTC pharm India | +918790379245 | AndhraPradesh, India | 1262 | 58 | Inquiry |
| Vihita Chem Private Limited | +91-9512002673 +91-9512002673 | Gujarat, India | 122 | 58 | Inquiry |
| Hyderabad | +91-9676447615 +91-9676447615 | Telangana, India | 192 | 58 | Inquiry |
| ORGANO FINE CHEMICALS | +91-91-22-42128300 +91-2242128300 | Mumbai, India | 258 | 58 | Inquiry |
| Sris Synthesis Pvt Ltd., | +91-9989522441 +91-9989522441 | Hyderabad, India | 281 | 58 | Inquiry |
| SVH BIOSCIENCES | +91-6303499280 +91-6303499280 | Hyderabad, India | 478 | 58 | Inquiry |
| VGS SYNTHESIS PRIVATE LIMITED | +91-9866975588 +91-9866975588 | Hyderabad, India | 1817 | 58 | Inquiry |
| AVIGYABIOSCIENCES PRIVATE LIMITED | +91-9849533087 +91-9849533087 | Telangana, India | 156 | 58 | Inquiry |
| Sintilla Medcoms Pvt Ltd | +91-4027808001 +91-8886733867 | Telangana, India | 307 | 58 | Inquiry |
| BIOCARE LABORATORIES | +91-9925391961 +91-9925391961 | Gujarat, India | 22 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| BTC pharm India | 58 |
| Vihita Chem Private Limited | 58 |
| Hyderabad | 58 |
| ORGANO FINE CHEMICALS | 58 |
| Sris Synthesis Pvt Ltd., | 58 |
| SVH BIOSCIENCES | 58 |
| VGS SYNTHESIS PRIVATE LIMITED | 58 |
| AVIGYABIOSCIENCES PRIVATE LIMITED | 58 |
| Sintilla Medcoms Pvt Ltd | 58 |
| BIOCARE LABORATORIES | 58 |
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