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5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

CAS No.: 124750-53-4

Chemical Name:: 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

Synonyms: TTMB;ENTERPRISESTANDARD;Losartan Impurity 9;Olmesartan TTMB impurity;5-[2-(4-methylphenyl)phenyl]-1-trityltetrazole;5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole;5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole;Olmesartan Medoxomil Impurity 24（Losartan Impurity 9）;N-(TRIPHENYLMETHYL)-5-(4'-METHYLBIPHENYL-2-YL)TETRAZOLE;n-(triphenylmethyl)-5-(4'-methylbiphenyl-2-yl-)terazole

CBNumber:: CB3438158

Molecular Formula:: C33H26N4

Molecular Weight:: 478.59

MOL File:: 124750-53-4.mol

MSDS File:: SDS

Modify Date:: 2024/6/15 22:11:33

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5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Properties

Melting point	166-169 °C(Solv: ethyl acetate (141-78-6); dichloromethane (75-09-2))
Boiling point	681.6±65.0 °C(Predicted)
Density	1.13±0.1 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform (Slightly)
form	Solid
pka	0.30±0.10(Predicted)
color	Off-White
CAS DataBase Reference	124750-53-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Danger
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362+P364-P403+P233-P501c

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Chemical Properties,Uses,Production

Chemical Properties

Off-white Solid

Uses

An intermediate in the preparation of labelled Candesartan.

Synthesis

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole is prepared by the reaction of trityl chloride and 2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl. The specific synthesis steps are as follows:
Dissolve compound 2 (200 g) with stirring at 40°C 700mL of acetone, Aqueous sodium hydroxide solution (40.67 g sodium hydroxide dissolved in 160 mL water) is added, Continue stirring for 1h, A solution of triphenylchloromethane in acetone (270.8 g of triphenylmethyl chloride dissolved in 800 mL of acetone) was initially added dropwise. The solid was added dropwise and gradually evolved into a white turbid liquid. The reaction was monitored by TLC until it was completely filtered off and washed with water to give a solid as intermediate 3. The solid was blow dried at 50°C to give white intermediate 3 (385 g), yield: 95.2%, HPLC: 99.44%.
5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole synthesis

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Preparation Products And Raw materials

Raw materials

Preparation Products

5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole Suppliers

Global( 175)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Viyash Life Sciences Pvt Ltd	+91-4023635052 +91-4023635052	Telangana, India	213	58	Inquiry
Lakshmi Farmachem	+91-9948795885 +91-9550886476	Telangana, India	407	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6522	58	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16220	58	Inquiry

Supplier	Advantage
Viyash Life Sciences Pvt Ltd	58
Lakshmi Farmachem	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
CHEMSWORTH	30
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
OCEAN TRADING CORPORATION	58
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58

124750-53-4(5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole)Related Search:

Triphenylmethyl Chloride Trityl candesartan Trityl Irbesartan Trityl candesartan cilexetil 4,4'-Dimethylbiphenyl

2,3,5-Triphenyltetrazolium chloride Silicone oil (high temperature) Chlorodimethylphenylsilane Trityl olmesartan 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

2-Butyl-4-chloro-5-hydroxymethyl-1-[[2'-(1H-2-triphenylmethyl-tetrazol-5-yl)biphenyl-4-yl]methyl]imidazole 4-Phenyltoluene methylphenyl silicone resin Benzyl N-[(2(Trityltetrazol-5-yl-1,1biphenyl-4-yl]-methyl-2-amino-3-methylbutanoate 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole

AKOS 91708 AKOS 91707

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5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 5-[4'-METHYL (1,1'-BIPHENYL)-2-YL]-1-TRIPHENYLMETHYL-TETRAZOLE n-(triphenylmethyl)-5-(4'-methylbiphenyl-2-yl-)terazole N-(TRIPHENYLMETHYL)-5-(4'-METHYLBIPHENYL-2-YL)TETRAZOLE 5-(4'-Methyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole 5-[4''-METHYL (1,1''-BIPHENYL)-2-YL]-1-TRIPHENYLMETHYL-TETRAZOLE 98.5+% N-TriphenylMethyl-5-[4'-Methylbiphenyl-2-yl]tetrazole-d4 5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole ENTERPRISESTANDARD 5-(5-Methyl-2-phenylphenyl)-1-(triphenylMethyl)-1H-1,2,3,4-tetrazole Losartan IMpurity (5-(4'-Methylbiphenyl-2-yl)-1-Trityl-1H-Tetrazole) TTMB 5-[2-(4-methylphenyl)phenyl]-1-trityltetrazole N-(Triphenylmethyl)-5-(4'-Methylbiphenyl-2-Yl-)Tetrazole (Ttmb) Olmesartan TTMB impurity 1-[2-(diphenylmethyl)phenyl]-5-[2-(4-methylphenyl)phenyl]tetrazole Losartan Impurity 9 Olmesartan Medoxomil impurity 8/Olmesartan TTMB Impurity/5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole 1H-Tetrazole, 5-(4'-methyl[1,1'-biphenyl]-2-yl)-1-(triphenylmethyl)- Losartan Impurity （5-?(4’-?Methyl-?[1,?1’-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole） 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole USP/EP/BP 5-?(4'-?Methyl-?[1,?1'-?biphenyl]?-?2-?yl)?-?1-?trityl-?1H-?tetrazole DISCONTINUED. Please see T889170 Olmesartan Medoxomil Impurity 24（Losartan Impurity 9） 5-(4'-Methylbiphenyl-2-yl)-1-trityl-1H-tetrazole 5-(4'-Methyl-[1,1'-biphenyl]-2-yl)-1-trityl-1H-tetrazole 124750-53-4 C34H29N4 C33H26N4 C33H22D4N4 Biphenyl & Diphenyl ether API intermediates Hypertension