IDRA 21

CAS No.: 22503-72-6

Chemical Name:: IDRA 21

Synonyms: AMPAKINE;IDRA 21;IDRA 21,98%;S-18986 IDRA-21 AMPAKINE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE;7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-...;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE;7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE;7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide;IDRA 21 Benzothiadiazine,7-chloro- 3,4-dihydro-3-methyl-,1,1- dioxide

CBNumber:: CB3468324

Molecular Formula:: C8H9ClN2O2S

Molecular Weight:: 232.69

MOL File:: 22503-72-6.mol

MSDS File:: SDS

Modify Date:: 2024/6/15 22:11:33

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IDRA 21 Properties

Melting point	209 °C(Solv: acetic acid (64-19-7))
Boiling point	405.1±55.0 °C(Predicted)
Density	1.394±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	DMSO (Slightly), Methanol (Slightly, Sonicated)
form	Solid
pka	9.78±0.40(Predicted)
color	Off-White to Pale Yellow
InChIKey	VZRNTCHTJRLTMU-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P280-P305+P351+P338
Safety Statements	24/25
WGK Germany	3

IDRA 21 price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	I5773	IDRA 21 ≥98%	22503-72-6	5MG	₹24183.05	2022-06-14	Buy

Product number	Packaging	Price	Buy
I5773	5MG	₹24183.05	Buy

IDRA 21 Chemical Properties,Uses,Production

Chemical Properties

white to off-white crystalline powder

Uses

IDRA-21 is a benzothiadiazine derivative and a positive allosteric modulator of glutamate AMPA receptors (1,2,3,4). It is able to increase excitatory synaptic strength by inhibiting AMPA receptor desensitization. IDRA 21 may exhibit therapeutic effects to ameliorate memory deficits in patients with cognitive impairments such as Alzheimer''s disease.

Biological Activity

Inhibits AMPA receptor desensitization and enhances cognition by a related mechanism. More able to cross the blood-brain barrier than cyclothiazide (6-Chloro-3,4-dihydro-3-(5-norbornen-2-yl)-2H-1,2,4-benzothiazidiazine-7-sulfonamide-1,1-dioxide ).

IDRA 21 Preparation Products And Raw materials

Raw materials

2-Amino-5-chlorobenzenesulfonamide Hydrochlorothiazide Related Compound (N'-(2-Acetyl-sulfamoyl-4-chloro-phenyl) Acetamide) Ethanol Acetaldehyde

Preparation Products

IDRA 21 Suppliers

Global( 144)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Prakash Chemicals Agencies Private Limited	08069033721Ext 557	Vadodara, India	10	58	Inquiry
Hubei Langyou International Trading Co., Ltd	+8618874586545	China	197	58	Inquiry
Wuhan Qiami Technology Co., Ltd	+8618062705058	China	148	58	Inquiry
HangZhou RunYan Pharma Technology Co.,LTD.	+86-88660901 +86-18112526015	China	326	58	Inquiry
Hebei Kingfiner Technology Development Co.Ltd	+86-15532196582 +86-15373005021	China	2989	58	Inquiry
Wuhan Haorong Biotechnology Co.,ltd	+86-18565342920; +8618565342920	China	293	58	Inquiry
Hubei Chuyan Biopharmaceutical Co., Ltd	+1-027-87896938 +15172028168	China	24	58	Inquiry
Shaanxi TNJONE Pharmaceutical Co., Ltd	+8618740459177	China	1142	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Prakash Chemicals Agencies Private Limited	58
Hubei Langyou International Trading Co., Ltd	58
Wuhan Qiami Technology Co., Ltd	58
HangZhou RunYan Pharma Technology Co.,LTD.	58
Hebei Kingfiner Technology Development Co.Ltd	58
Wuhan Haorong Biotechnology Co.,ltd	58
Hubei Chuyan Biopharmaceutical Co., Ltd	58
Shaanxi TNJONE Pharmaceutical Co., Ltd	58

22503-72-6(IDRA 21)Related Search:

Methyltrichlorosilane Benzyl chloride Triphosgene IDRA 21 2-Amino-5-chlorobenzenesulfonamide

IDRA 21 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE 1,1-DIOXIDE 7-CHLORO-3-METHYL-3,4-DIHYDRO-2H-1,2,4-BENZOTHIADIAZINE S,S-DIOXIDE IDRA 21,98% 7-chloro-3-methyl-3,4-dihydro-2H-benzo[e][1,2,4]thiadiazine 1,1-dioxide 7-Chloro-3,4-dihydro-3-methyl-2H-1,2,4-benzothiadiazine 1,1-dioxide 2H-1,2,4-Benzothiadiazine,7-chloro-3,4-dihydro-3-Methyl-, 1,1-dioxide IDRA 21,7-Chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazineS,S-dioxide 7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-... IDRA 21 Benzothiadiazine,7-chloro- 3,4-dihydro-3-methyl-,1,1- dioxide AMPAKINE S-18986 IDRA-21 AMPAKINE 22503-72-6 Ligand-Gated Ion Channels Ion Channels Ionotropic Glutamate Receptor Modulators Cell Signaling and Neuroscience Cell Biology BioChemical API