NIALAMIDE
- CAS No.
- 51-12-7
- Chemical Name:
- NIALAMIDE
- Synonyms
- BEIH;Mygal;Espril;Niamid;Niazin;Nyazin;Nyezin;P 1133;Surgex;NF-XIII
- CBNumber:
- CB3687497
- Molecular Formula:
- C16H18N4O2
- Molecular Weight:
- 298.34
- MOL File:
- 51-12-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:06
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302+H312+H332-H315-H319-H335-H351 |
| Precautionary statements | P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38-40 |
| Safety Statements | 22-26-36 |
| RIDADR | 3249 |
| WGK Germany | 3 |
| RTECS | NS1225000 |
| F | 10 |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| Toxicity | LD50 in mice, rats (mg/kg): 1000, 1700 orally; 742, 760 i.p. (Delahunt) |
NIALAMIDE Chemical Properties,Uses,Production
Chemical Properties
White, crystalline powder. Low solubility in water; good solubility in slightly acid solution. It is stable in crystalline form, suspension, and solution.
Uses
Nialamide is a nonselective monoamine oxidase (MAO) inhibitor that is used as an antidepressant.
World Health Organization (WHO)
Nialamide, a monoamine oxidase inhibitor (MAOI), was introduced in 1959 for the treatment of depressive illness. Subsequently concern regarding potentially serious interactions between MAOIs and foods containing tyramine inspired much restrictive regulatory action. However, MAOIs still retain a place in the treatment of serious depressive illness although there is no international consensus on which compounds should be preferred. Thus nialamide remains available in several countries.
General Description
Nialamide is an antidepressant drug and its effect on β-adrenergic receptor-adenylate cyclase system of rat pineal gland has been studied. Antidepressant action of the combination of nialamide and 5-hydroxytryptophan has been evaluated.
Hazard
Toxic in overdose.
Safety Profile
Poison by intravenous andintraperitoneal routes. Moderately toxic by ingestion.Mutation data reported. Experimental reproductiveeffects. An antidepressant. When heated to decompositionit emits toxic fumes of NOx.
NIALAMIDE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9155 | 58 | Inquiry |
| https://www.shachemlin.cn/ | 15021879576 | China | 9974 | 58 | Inquiry |
| Jinan Jiuli Biotechnology Co. , Ltd. | 14768611851 | China | 2041 | 58 | Inquiry |
| Sigma-Aldrich | 021-61415566 800-8193336 | China | 51471 | 80 | Inquiry |
| MP Biomedicals, Inc. | 949 833 2500 | United States | 6566 | 81 | Inquiry |
| Nacalai Tesque, Inc. | 81 75 251 1723 | Japan | 6048 | 75 | Inquiry |
| ASDI Incorporated | 888 577 ASDI | United States | 6928 | 67 | Inquiry |