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Cefeprime dihydrochloride

CAS No.: 107648-80-6

Chemical Name:: Cefeprime dihydrochloride

Synonyms: CEFEPIME HCL;Cefepime DiHCl;Cefepime Impurity 16;CefepiMe hydrochloric;Cefepime Hydrochlorede;CEFEPIME DIHYDROCHLORIDE;CEFEPRIME DIHYDROCHLORIDE;CEFEPIME HCL STERILE POWDER;Cefepime Hydrochloride/arginine;Cefeprime dihydrochloride USP/EP/BP

CBNumber:: CB3739703

Molecular Formula:: C19H25ClN6O5S2

Molecular Weight:: 553.49

MOL File:: 107648-80-6.mol

Modify Date:: 2024/3/19 15:49:44

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Cefeprime dihydrochloride Properties

Melting point	230 °C (decomp)
solubility	Water:10.0(Max Conc. mg/mL);17.5(Max Conc. mM) DMSO:6.0(Max Conc. mg/mL);10.5(Max Conc. mM)
CAS DataBase Reference	107648-80-6(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS08,GHS05
Signal word	Danger
Hazard statements	H314-H317-H334
Precautionary statements	P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501-P261-P285-P304+P341-P342+P311-P501

Cefeprime dihydrochloride Chemical Properties,Uses,Production

Description

Cefepime Hydrochloride is the hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins.

Uses

Cefepime hydrochloride has been used as a pharmaceutical reference standard for the determination of analytes in pharmaceutical preparations by spectrophotometric and chromatographic techniques. Cefepime is commonly used in the treatment of severe atypical pneumonia and infections caused by multi-drug resistant microorganisms (e.g. Pseudomonas aeruginosa), and is also indicated for the empirical treatment of febrile neutropenia.

Definition

ChEBI: Cefepime hydrochloride is a hydrochloride that is the monohydrate of the dihydrochloride salt of cefepime. It has a role as an antibacterial drug. It is a hydrochloride, a hydrate and a cephalosporin. It contains a cefepime(1+).

Cefeprime dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Cefeprime dihydrochloride Suppliers

Global( 102)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
OCEAN TRADING CORPORATION	+91(22) 24921669	New Delhi, India	6211	58	Inquiry
Clinse Labs Private Limited.	+091-40-23778611	New Delhi, India	372	30	Inquiry
MS Pharmachem	08048371669Ext 537	Mumbai, India	13	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21669	55	Inquiry
Hebei Guanlang Biotechnology Co., Ltd.	+86-19930503282	China	8822	58	Inquiry
Xiamen AmoyChem Co., Ltd	+86-592-6051114 +8618959220845	China	6387	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29825	58	Inquiry
SIMAGCHEM CORP	+86-13806087780	China	17367	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry

Supplier	Advantage
OCEAN TRADING CORPORATION	58
Clinse Labs Private Limited.	30
MS Pharmachem	58
Henan Tianfu Chemical Co.,Ltd.	55
Hebei Guanlang Biotechnology Co., Ltd.	58
Xiamen AmoyChem Co., Ltd	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
SIMAGCHEM CORP	58
TargetMol Chemicals Inc.	58

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Cefepime hydrochloride CEFEPIME DIHYDROCHLORIDE MONOHYDRATE AMINO ACIDS

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CEFEPIME HCL STERILE POWDER CEFEPRIME DIHYDROCHLORIDE (6R,7R)-7-[[(2E)-2-(2-Amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-3-[(1-methylpyrrolidin-1-ium-1-yl)methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid chloride hydrochloride PyrrolidiniuM,1-[[(6R,7R)-7-[[(2Z)-2-(2-aMino-4-thiazolyl)-2-(Me CefepiMe hydrochloric PyrrolidiniuM,1-[[(6R,7R)-7-[[(2Z)-2-(2-aMino-4-thiazolyl)-2-(MethoxyiMino)acetyl]aMino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]-1-Methyl-,chloride, hydrochloride (1:1:1 CEFEPIME DIHYDROCHLORIDE CEFEPIME HCL 1-(((6R,7R)-7-((Z)-2-(2-aMinothiazol-4-yl)-2-(MethoxyiMino)acetaMido)-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)Methyl)-1-Methylpyrrolidin-1-iuM chloride hydrochloride Cefepime Hydrochloride/arginine Cefepime Hydrochlorede 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)(methoxyimino)acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methyl-pyrrolidinium chloride hydrochloride Cefepime Dihydrochloride : L(+)-Arginine Cefepime Impurity 16 Cefeprime dihydrochloride USP/EP/BP TIANFU CHEM-- Cefeprime dihydrochloride Cefepime DiHCl Cefepime dihydrochloride(L-Arginine) Sterile 107648-80-6 C19H24N6O5S22HCl C19H24N6O5S22HCLH2O C19H25N6O5S2ClHCl C19H26Cl2N6O5S2 Pharmaceutical intermediate Cefepime