BAFILOMYCIN A1
- CAS No.
- 88899-55-2
- Chemical Name:
- BAFILOMYCIN A1
- Synonyms
- CS-1163;afilomycin A1;BAFILOMYCIN A1;Bafilomycin A1,95%;BAFILOMYCIN A1 95%;BAFILOMYCIN A1, 98+%;Bafilomycin A1(Baf-A1);BAFILOMYCIN A1 USP/EP/BP;BafilomycinA1fromStreptomycesgriseus;BAFILOMYCIN A1, STREPTOMYCES GRISEUS
- CBNumber:
- CB3743951
- Molecular Formula:
- C35H58O9
- Molecular Weight:
- 622.83
- MOL File:
- 88899-55-2.mol
- Modify Date:
- 2023/9/20 16:43:00
| Melting point | >106°C (dec.) |
|---|---|
| Boiling point | 582.86°C (rough estimate) |
| Density | 1.0594 (rough estimate) |
| refractive index | 1.5000 (estimate) |
| RTECS | RN9781000 |
| Flash point | 87℃ |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 5 mg/ml, with warming). |
| pka | 12.66±0.70(Predicted) |
| form | Powder or Solid |
| color | White to off-white |
| Water Solubility | Soluble in methanol, ethanol, acetone and chloroform. Insoluble in water. |
| BRN | 4730700 |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335-H227 | |||||||||
| Precautionary statements | P210e-P280a-P370+P378a-P403+P235-P501a-P261-P304+P340-P305+P351+P338-P405 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| RIDADR | 3172 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29419090 | |||||||||
| NFPA 704 |
|
BAFILOMYCIN A1 price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B1793 | Bafilomycin A1 from Streptomyces griseus ≥90% (HPLC) | 88899-55-2 | 2μG | ₹10359.53 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML1661 | Bafilomycin A1 Ready Made Solution 0.16?mM in DMSO, from Streptomyces griseus | 88899-55-2 | 0.1ML | ₹18713.1 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B1793 | Bafilomycin A1 from Streptomyces griseus ≥90% (HPLC) | 88899-55-2 | 10μG | ₹27322.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 196000 | Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophag | 88899-55-2 | 10μG | ₹21130 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 196000 | Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem Bafilomycin A1, CAS 88899-55-2, acts as a highly potent and specific inhibitor of vacuolar-type H+-ATPase (Ki = 500 pM). Blocks the fusion of autophag | 88899-55-2 | 1SET | ₹44200.01 | 2022-06-14 | Buy |
BAFILOMYCIN A1 Chemical Properties,Uses,Production
Description
Bafilomycin A1 is a fungal metabolite that has been found in Streptomyces and has diverse biological activities. It is an inhibitor of vacuolar H+-ATPases (V-ATPases; Ki = 0.5 nM in N. crassa vacuolar membranes) and is greater than 1,000-fold selective for V-ATPases over Na+/K+-, Ca2+-, and H+-ATPases. Bafilomycin A1 (100 nM) inhibits autophagosome maturation and protein degradation in H-4-II-E cells. It inhibits chloroquine-induced apoptosis in primary cerebellar granule neurons (CGNs) but not chloroquine-induced inhibition of macroautophagy. Bafilomycin A1 (100 nM) reduces viral yield in the culture supernatant of Vero E6 and Huh7 cells, as well as HEK293T cells expressing human angiotensin-converting enzyme 2 (ACE2), infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It also reduces lung RNA copy numbers and viral pneumonia in ACE2 transgenic mice infected with SARS-CoV-2 when administered at a dose of 0.1 mg/kg.
Chemical Properties
white to off-white powder
Uses
Bafilomycin A1 is a member of a potent family of macrocyclic lactones with broad spectrum biological activity, including activity against bacteria, yeast, fungi, nematodes, insects and tumour cell lines. Bafilomycin A1 is an inhibitor of vacuolar-type ATPase.
Definition
ChEBI: The most used of the bafilomycins, a family of toxic macrolide antibiotics derived from Streptomyces griseus.
General Description
A macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
Biological Activity
Highly potent, selective inhibitor of vacuolar H + -ATPases (IC 50 = 500 pM as measured in chromaffin granule membranes). Selective over other ATP hydrolyzing enzymes such as F-ATPases, Ca 2+ -ATPases, Na + /K + -ATPases and plasma membrane H + -ATPases.
BAFILOMYCIN A1 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | China | 9338 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26216 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hebei Duling International Trade Co. LTD | +8617333973358 | China | 15438 | 58 | Inquiry |
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