Berberine hydrochloride
- CAS No.
- 633-65-8
- Chemical Name:
- Berberine hydrochloride
- Synonyms
- BERBERINE HCL;BBR;BERBERIN HCL;5,6-DIHYDRO-9,10-DIMETHOXY-BENZO[G]-1,3-BENZODIOXOLO[5,6-A]QUINOLIZINIUM, CHLORIDE;CI 75160;Kyoberin;NSC 646666;UMBELLATINE;Benzodioxide;Berberine chL
- CBNumber:
- CB3758777
- Molecular Formula:
- C20H18ClNO4
- Molecular Weight:
- 371.81
- MOL File:
- 633-65-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/8/5 12:01:54
| Melting point | 204-206 °C (dec.) |
|---|---|
| storage temp. | Inert atmosphere,2-8°C |
| solubility | methanol: soluble |
| form | Yellow powder |
| Colour Index | 75160 |
| color | Yellow powder |
| Water Solubility | SOLUBLE IN COLD WATER |
| BRN | 3836585 |
| Stability | Hygroscopic |
| InChI | InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1 |
| InChIKey | VKJGBAJNNALVAV-UHFFFAOYSA-M |
| SMILES | C12C=C3C(C(OC)=C(OC)C=C3)=C[N+]=1CCC1=CC3=C(OCO3)C=C21.[Cl-] |
| CAS DataBase Reference | 633-65-8 |
| EPA Substance Registry System | Berberine chloride (633-65-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H312-H315-H319-H332-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 24/25-36-26 |
| RIDADR | 1544 |
| WGK Germany | 2 |
| RTECS | DR9866400 |
| F | 3-10 |
| TSCA | Yes |
| HazardClass | 6.1(b) |
| PackingGroup | III |
| HS Code | 29349990 |
| Toxicity | LD50 orl-rat: >15 g/kg KSRNAM 8,654,74 |
Berberine hydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B3251 | Berberine chloride form | 633-65-8 | 5G | ₹4459.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B3251 | Berberine chloride form | 633-65-8 | 10G | ₹7815.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1502 | Berberine Chloride Pharmaceutical Secondary Standard; Certified Reference Material | 633-65-8 | 500MG | ₹14884.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B3251 | Berberine chloride form | 633-65-8 | 25G | ₹19506.65 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 200275 | Berberine Chloride A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC?? = 140 pM over EC?? = 2.1 nM for it | 633-65-8 | 25MG | ₹3500 | 2022-06-14 | Buy |
Berberine hydrochloride Chemical Properties,Uses,Production
Chemical Properties
yellow crystalline powder
Uses
Berberine hydrochloride: antiarrhythmic, alpha2 agonist, anticonvulsant, antiinflammatory, antibacterial, antifungal, antitrypanosomal, antineoplastic, immunostimulant
Definition
Berberine Chloride is the orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Berberine is a naturally occurring yellow alkaloid in some plants. Berberine HCL is the native form combine with hydrogen chloride to make it more stable.
Biological Functions
Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.
General Description
A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC50 = 140 pM over EC50 = 2.1 nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC50 = 2 nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4+ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.
Safety Profile
Poison by intraperitoneal route.Slightly toxic by ingestion. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx andCl-.
Purification Methods
Berberine chloride crystallises from water to give the dihydrate. The anhydrous salt may be obtained by recrystallisation from EtOH/Et2O, wash the crystals with Et2O and dry them in a vacuum. The iodide has m 250o(dec) (from EtOH). [Perkin J Chem Soc 113 503 1918, Kametani et al. J Chem Soc(C) 2036 1969, Beilstein 27 I 515, 27 II 567.]
Clinical claims and research
People most commonly use berberine for diabetes, high levels of cholesterol or other fats in the blood, and high blood pressure. It is also used for burns, canker sores, liver disease, and many other conditions but there is no good scientific evidence to support many of these uses.
Berberine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shashi Phytochemical Industries | +91-9829050049 +91-9829050049 | Rajasthan, India | 2 | 58 | Inquiry |
| Himpharm | +91-9816648055 +91-9816664455 | Himachal Pradesh, India | 29 | 58 | Inquiry |
| Inga Pharmaceuticals | +91-2228202932 +91-2228202932 | Maharashtra, India | 38 | 58 | Inquiry |
| Namiex Chemicals Private Limited | +91-1862225256 +91-9988625256 | Punjab, India | 13 | 58 | Inquiry |
| Indo Phytochem Pharmaceuticals | +91-9315656907 +91-9816687908 | Himachal Pradesh, India | 11 | 58 | Inquiry |
| Natural Remedies Pvt Ltd | +91 (80) 4020-9999 | New Delhi, India | 110 | 50 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
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