Berberine hydrochloride

Berberine hydrochloride Properties

Melting point	204-206 °C (dec.)
storage temp.	Inert atmosphere,2-8°C
solubility	methanol: soluble
form	Yellow powder
Colour Index	75160
color	Yellow powder
Water Solubility	SOLUBLE IN COLD WATER
BRN	3836585
Stability	Hygroscopic
InChI	InChI=1S/C20H18NO4.ClH/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2;/h3-4,7-10H,5-6,11H2,1-2H3;1H/q+1;/p-1
InChIKey	VKJGBAJNNALVAV-UHFFFAOYSA-M
SMILES	C12C=C3C(C(OC)=C(OC)C=C3)=C[N+]=1CCC1=CC3=C(OCO3)C=C21.[Cl-]
CAS DataBase Reference	633-65-8
EPA Substance Registry System	Berberine chloride (633-65-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06,GHS07
Signal word	Danger
Hazard statements	H301-H312-H315-H319-H332-H335
Precautionary statements	P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
Hazard Codes	Xn
Risk Statements	20/21/22-36/37/38
Safety Statements	24/25-36-26
RIDADR	1544
WGK Germany	2
RTECS	DR9866400
F	3-10
TSCA	Yes
HazardClass	6.1(b)
PackingGroup	III
HS Code	29349990
Toxicity	LD50 orl-rat: >15 g/kg KSRNAM 8,654,74

Berberine hydrochloride price More Price(7)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	B3251	Berberine chloride form	633-65-8	5G	₹4459.9	2022-06-14	Buy
Sigma-Aldrich(India)	B3251	Berberine chloride form	633-65-8	10G	₹7815.65	2022-06-14	Buy
Sigma-Aldrich(India)	PHR1502	Berberine Chloride Pharmaceutical Secondary Standard; Certified Reference Material	633-65-8	500MG	₹14884.38	2022-06-14	Buy
Sigma-Aldrich(India)	B3251	Berberine chloride form	633-65-8	25G	₹19506.65	2022-06-14	Buy
Sigma-Aldrich(India)	200275	Berberine Chloride A highly potent and selective oxysterol EBI2 (GPR183) agonist (Kd) = 450 pM in a saturation binding assay, and EC?? = 140 pM over EC?? = 2.1 nM for it	633-65-8	25MG	₹3500	2022-06-14	Buy

Product number	Packaging	Price	Buy
B3251	5G	₹4459.9	Buy
B3251	10G	₹7815.65	Buy
PHR1502	500MG	₹14884.38	Buy
B3251	25G	₹19506.65	Buy
200275	25MG	₹3500	Buy

Berberine hydrochloride Chemical Properties,Uses,Production

Chemical Properties

yellow crystalline powder

Uses

Berberine hydrochloride: antiarrhythmic, alpha2 agonist, anticonvulsant, antiinflammatory, antibacterial, antifungal, antitrypanosomal, antineoplastic, immunostimulant

Definition

Berberine Chloride is the orally bioavailable, hydrochloride salt form of berberine, a quaternary ammonium salt of an isoquinoline alkaloid and active component of various Chinese herbs, with potential antineoplastic, radiosensitizing, anti-inflammatory, anti-lipidemic and antidiabetic activities. Berberine is a naturally occurring yellow alkaloid in some plants. Berberine HCL is the native form combine with hydrogen chloride to make it more stable.

Biological Functions

Although the mechanisms of action through which berberine exerts its effects are not yet fully elucidated, upon administration this agent appears to suppress the activation of various proteins and/or modulate the expression of a variety of genes involved in tumorigenesis and inflammation, including, but not limited to transcription factor nuclear factor-kappa B (NF-kB), myeloid cell leukemia 1 (Mcl-1), B-cell lymphoma 2 (Bcl-2), B-cell lymphoma-extra large (Bcl-xl), cyclooxygenase (COX)-2, tumor necrosis factor (TNF), interleukin (IL)-6, IL-12, inducible nitric oxide synthase (iNOS), intercellular adhesion molecule-1 (ICAM-1), E-selectin, monocyte chemoattractant protein-1 (MCP-1), C-X-C motif chemokine 2 (CXCL2), cyclin D1, activator protein (AP-1), hypoxia-inducible factor 1 (HIF-1), signal transducer and activator of transcription 3 (STAT3), peroxisome proliferator-activated receptor (PPAR), arylamine N-acetyltransferase (NAT), and DNA topoisomerase I and II. The modulation of gene expression may induce cell cycle arrest and apoptosis, and inhibit cancer cell proliferation. In addition, berberine modulates lipid and glucose metabolism.

General Description

A highly potent and selective oxysterol EBI2 (GPR183) agonist (K_d) = 450 pM in a saturation binding assay, and EC₅₀ = 140 pM over EC₅₀ = 2.1 nM for its enantiomer, 7β,25-OHC, in a GTP-γS binding assay). Dose-dependently suppresses forskolin-induced cAMP accumulation in an EBI2-expressing SK-N-MC/CRE-β-galactosidase cell line (IC₅₀ = 2 nM), but not in control cells. Stimulates migration of LPS-activated spleen B-cells and anti-CD3/CD28-activated CD4⁺ T-cells in a dose-dependent manner. In addition, pharmacological inhibition of its biosynthesis in vivo by Clotrimazole, a CYP7B1inhibitor, promotes the migration of adoptively transferred pre-activated B cells to the T/B boundary, mimicking the phenotype of pre-activated B cells in EBI2-deficient mice.

Side effects

Some side effects of berberine have been reported in research studies, primarily gastrointestinal symptoms such as nausea, abdominal pain, bloating, constipation, or diarrhea. Berberine may interact with medicines. For example, it has been shown to interact with cyclosporine, a drug used to prevent rejection of transplanted organs. If you take medicine, talk with your health care provider if you consider taking berberine supplements. Exposure to berberine has been linked to a harmful buildup of bilirubin in infants, which can cause brain damage. Therefore, berberine is likely to be unsafe for infants and may also be unsafe for use during pregnancy or while breastfeeding because of possible effects on the fetus or infant.

Safety Profile

Poison by intraperitoneal route.Slightly toxic by ingestion. Mutation data reported. Whenheated to decomposition it emits toxic vapors of NOx andCl-.

Purification Methods

Berberine chloride crystallises from water to give the dihydrate. The anhydrous salt may be obtained by recrystallisation from EtOH/Et2O, wash the crystals with Et2O and dry them in a vacuum. The iodide has m 250o(dec) (from EtOH). [Perkin J Chem Soc 113 503 1918, Kametani et al. J Chem Soc(C) 2036 1969, Beilstein 27 I 515, 27 II 567.]

Clinical claims and research

People most commonly use berberine for diabetes, high levels of cholesterol or other fats in the blood, and high blood pressure. It is also used for burns, canker sores, liver disease, and many other conditions but there is no good scientific evidence to support many of these uses.

Berberine hydrochloride Preparation Products And Raw materials

Raw materials

Ethanone, 2-(5,8-dihydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizin-8-yl)-1-phenyl- Sulfuric acid Hydrochloric acid

Preparation Products

Berberine hydrochloride Suppliers

Global( 700)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Shashi Phytochemical Industries	+91-9829050049 +91-9829050049	Rajasthan, India	2	58	Inquiry
Himpharm	+91-9816648055 +91-9816664455	Himachal Pradesh, India	29	58	Inquiry
Inga Pharmaceuticals	+91-2228202932 +91-2228202932	Maharashtra, India	38	58	Inquiry
Namiex Chemicals Private Limited	+91-1862225256 +91-9988625256	Punjab, India	13	58	Inquiry
Indo Phytochem Pharmaceuticals	+91-9315656907 +91-9816687908	Himachal Pradesh, India	11	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6100	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Otto Chemie Pvt. Ltd.	+91 9820041841	Mumbai, India	5870	58	Inquiry
Indus Biowell LLP	08048978575	Mumbai, India	1	58	Inquiry
Angle Biopharma	08046067501	Ahmedabad, India	142	58	Inquiry

Supplier	Advantage
Shashi Phytochemical Industries	58
Himpharm	58
Inga Pharmaceuticals	58
Namiex Chemicals Private Limited	58
Indo Phytochem Pharmaceuticals	58
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Otto Chemie Pvt. Ltd.	58
Indus Biowell LLP	58
Angle Biopharma	58

Berberine hydrochloride Spectrum

Berberine hydrochloride(633-65-8)MS Berberine hydrochloride(633-65-8)¹HNMR Berberine hydrochloride(633-65-8)¹³CNMR Berberine hydrochloride(633-65-8)IR1 Berberine hydrochloride(633-65-8)IR2

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TIMTEC-BB SBB006488 NATURAL YELLOW 18 CHLORIDE NATURAL YELLOW 18 UMBELLATINE BERBERINE HYDROCHLORIDE BERBERINE HYDROCHLORIDE N-HYDRATE LABOTEST-BB LT00440956 CI 75160 3)benzodioxolo(5,6-a)quinolizinium,5,6-dihydro-9,10-dimethoxy-benzo(g)(c 9,10-Dimethoxy-5,6-dihydro-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium·chloride 9,10-Dimethoxy-5,6-dihydrobenzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium·chloride C.I.Natural Yellow 18 Kyoberin Berberine hydrochloride hydrate,97% BERBERINECHLORIDE(SH) Berberine chloride form,Natural Yellow18 Berberine Chloride (50 mg) NSC 646666 7,8,13,13a-Tetradehydro-9,10-diMethoxy-2,3-(Methylenedioxy)berbiniuM Chloride Berberin chloride dihydrate Berberine Chloride, JP Berberinehydrochloride，Berberine chloride form Benzo(g)(1,3)benzodioxolo(5,6-a)quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride Berbinium, 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-, chloride Berberine chloride ,98% 7,8,13,13a-tetradehydro-9,10-dimethoxy-2,3-(methylenedioxy)-berbiniuchlori berberiniumchloride BERBERINE CHLORIDE(AHP) Berberine chloride form Berberdine HCl 9,10-Dimethoxy-5,6-dihydro-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinolin-7-ium chloride Berberine chloride (TN) Berberine hydrochloride 633-65-8 Berberine Hydroch (2E)-3,7-dimethyl-1-octa-2,6-dienol Berberine Chloride - CAS 633-65-8 - Calbiochem Berberine HCl 98% Berberine chloride CRS Berberine Chloride RS Benzodioxide Berberine chL Berberine hydrochloride USP/EP/BP Shuanghuanglian hydrochloride Berberine hydrochloride powder beriberichloride Berberine Chloride (1065210) BERBERINE HCL BERBERIN HCL BBR 5,6-DIHYDRO-9,10-DIMETHOXY-BENZO[G]-1,3-BENZODIOXOLO[5,6-A]QUINOLIZINIUM, CHLORIDE Berberine HCI Berberine HCA Berberis Aristata Extract Berberine Hydrochloride Berberine Hcl Berberine hydrochloride 97% Gadoxetate Disodium Impurity 21 Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizinium, 5,6-dihydro-9,10-dimethoxy-, chloride (1:1) C10573950 BerberinEchloride Berberine Chloride(P) (AHP Verified)