Bromazepam
- CAS No.
- 1812-30-2
- Chemical Name:
- Bromazepam
- Synonyms
- KL-001;laxvii;Normoc;La xvii;Lekotam;Lexomil;Lexotan;Lectopam;Lexaurin;Lexilium
- CBNumber:
- CB3764505
- Molecular Formula:
- C14H10BrN3O
- Molecular Weight:
- 316.15
- MOL File:
- 1812-30-2.mol
- Modify Date:
- 2023/6/8 9:02:13
| Melting point | 237-238.5oC (dec.) |
|---|---|
| Boiling point | 490.7±45.0 °C(Predicted) |
| Density | 1.5573 (rough estimate) |
| refractive index | 1.6520 (estimate) |
| Flash point | 11 °C |
| storage temp. | 2-8°C |
| solubility | Practically insoluble in water, slightly soluble or sparingly soluble in ethanol (96 per cent) and in methylene chloride. |
| form | A crystalline solid |
| pka | pKa 2.5(spectro, polarographic) (Uncertain);5.2(spectro, polarographic) (Uncertain);11.8(spectro, polarographic) (Uncertain) |
| CAS DataBase Reference | 1812-30-2(CAS DataBase Reference) |
| NIST Chemistry Reference | Bromazepam(1812-30-2) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS02, GHS06, GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H301+H311+H331-H370 | |||||||||
| Precautionary statements | P210-P260-P280-P301+P310-P311 | |||||||||
| Hazard Codes | Xn,T,F | |||||||||
| Risk Statements | 22-36/37/38-39/23/24/25-23/24/25-11 | |||||||||
| Safety Statements | 26-36-45-36/37-16-7 | |||||||||
| RIDADR | 3249 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | DE9800000 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 2933330000 | |||||||||
| Toxicity | LD50 orally in rats: 3050 ±405 mg/kg (Goldenthal) | |||||||||
| NFPA 704 |
|
Bromazepam Chemical Properties,Uses,Production
Description
Bromazepam is a psychoactive benzodiazepine derivative and prescription drug that is commonly abused and often used in ‘drug-
Chemical Properties
Crystalline Solid
Uses
Controlled substance (depressant). Anxiolytic.
Enzyme inhibitor
This lipophilic valium-like benzodiazepine (FW = 316.20 g/mol; CAS 1812- 30-2; IUPAC Name: 7-bromo-5-(pyridin-2-yl)-1H-benzo[e][1,4]diazepin- 2(3H)-one), is a long-lasting anxiolytic agent used to treat anxiety or panic states. Like diazepam, bromazepam is a positive allosteric modulator of GABAA receptors, promoting GABA binding, which in turn increases the total conduction of chloride ions across the neuronal cell membrane. Like other benzodiazepines, bromazepam also inhibits the acetylcholine receptoroperated potassium current. Bromazepam is mainly metabolized by oxidative pathways within the liver.