3-Chloropropiononitrile
- CAS No.
- 542-76-7
- Chemical Name:
- 3-Chloropropiononitrile
- Synonyms
- 3-Chloropropanenitrile;3-CHLOROPROPIONITRILE;CH2ClCH2CN;usafa-8798;USAF a-8798;3-Chlorpropannitril;rcrawastenumberp027;3-choropropionitrile;3-Chloropropuinitrile;3-chloro-propionitril
- CBNumber:
- CB3853791
- Molecular Formula:
- C3H4ClN
- Molecular Weight:
- 89.52
- MOL File:
- 542-76-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/14 15:18:26
| Melting point | ?52-?50 °C (lit.) |
|---|---|
| Boiling point | 174-176 °C (lit.) |
| Density | 1.144 g/mL at 25 °C (lit.) |
| refractive index |
n |
| Flash point | 168 °F |
| storage temp. | Store below +30°C. |
| solubility | 45g/l |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Water Solubility | 4.50 g/100 mL |
| Merck | 14,2160 |
| BRN | 1098454 |
| CAS DataBase Reference | 542-76-7(CAS DataBase Reference) |
| NIST Chemistry Reference | Cl(CH2)2CN(542-76-7) |
| EPA Substance Registry System | 3-Chloropropionitrile (542-76-7) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300-H315-H319 | |||||||||
| Precautionary statements | P301+P310+P330-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | T+ | |||||||||
| Risk Statements | 23-28 | |||||||||
| Safety Statements | 36/37/39-45 | |||||||||
| RIDADR | UN 3276 6.1/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UG1400000 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29269095 | |||||||||
| Toxicity | LD50 orally in mice, rats: 9, 100 mg/kg, Fassett in Industrial Hygiene and Toxicology vol. 2, F. A. Patty, Ed. (Interscience, New York, 2nd ed., 1962) pp 2025-2026 | |||||||||
| NFPA 704 |
|
3-Chloropropiononitrile price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | C69101 | 3-Chloropropionitrile 98% | 542-76-7 | 100G | ₹10110.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C69101 | 3-Chloropropionitrile 98% | 542-76-7 | 500G | ₹36101.38 | 2022-06-14 | Buy |
| TCI Chemicals (India) | C0277 | 3-Chloropropionitrile min. 98.0 % | 542-76-7 | 25ML | ₹2500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | C0277 | 3-Chloropropionitrile min. 98.0 % | 542-76-7 | 500ML | ₹10800 | 2022-05-26 | Buy |
3-Chloropropiononitrile Chemical Properties,Uses,Production
Chemical Properties
3-Chloropropionitrile is a combustible, colorless liquid with an acrid odor
Uses
In pharmaceutical and polymer synthesis. Combines the reactivity of a nitrile and an alkyl halide. Because of the cyano group the chlorine atom is more reactive than in ordinary alkyl halides.
Production Methods
3-Chloropropionitrile [542-76-7], 3-chloropropanenitrile, b-chloropropionitrile, ClCH2 CH2CN, Mr 89.53, mp-51℃, bp 175 –176℃ (101.3 kPa), n20D 1.4360, d204 1.1573, is a colorless liquid miscible with acetone, benzene, ethanol and diethyl ether. It can be obtained by hydrochlorination of acrylonitrile with hydrochloric acid [49] and is used as an organic intermediate in the synthesis of the H2-receptor famotidine.
General Description
Colorless liquid with a characteristic acrid odor. Used in pharmaceutical and polymer synthesis.
Reactivity Profile
Toxic gas (hydrogen chloride) is released when the compound is heated above 266 F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat. [EPA, 1998].
Hazard
Toxic by ingestion, inhalation, and skin contact. Combustible.
Health Hazard
Toxic effects are a result of systemic cyanide poisoning. (Non-Specific -- Cyanide) Few poisons are more rapidly lethal. Average oral lethal dose for hydrogen cyanide is approximately 60-90 mg (corresponds to 200 mg of potassium cyanide). Cause of death is lack of oxygen to the body's cells (especially the brain and heart) as a result of the chemical inhibiting cell enzymes.
Fire Hazard
Toxic gas (hydrogen chloride) is released when the compound is heated above 266F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat.
Potential Exposure
This material is used in pharmaceutical manufacture and in polymer synthesis.
Shipping
UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).
Incompatibilities
Contact with strong oxidizers may cause a fire and explosion hazard
3-Chloropropiononitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Unisource Chemicals Private Limited | 08048372772Ext 301 | Maharashtra, India | 290 | 58 | Inquiry |
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| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 | CHINA | 1320 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
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