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ChemicalBook > Product Catalog >API >Digestive system drugs >Antacid and Mucosal protective Drugs >Famotidine

Famotidine

Famotidine Structure
CAS No.
76824-35-6
Chemical Name:
Famotidine
Synonyms
pepcid;Ifada;ganor;mk208;gaster;motiax;muclox;pepdul;peptan;Amfamox
CBNumber:
CB5706585
Molecular Formula:
C8H15N7O2S3
Molecular Weight:
337.45
MOL File:
76824-35-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:11
Request For Quotation

Famotidine Properties

Melting point 163-164°C
Boiling point 562.7±60.0 °C(Predicted)
Density 1.5111 (rough estimate)
refractive index 1.7400 (estimate)
storage temp. 2-8°C
solubility Very slightly soluble in water, freely soluble in glacial acetic acid, very slightly soluble in anhydrous ethanol, practically insoluble in ethyl acetate. It dissolves in dilute mineral acids
form Solid
pka pKa 6.76(H2O t=23.0) (Uncertain)
color White to Off-White
Water Solubility 1.1 mg/mL
BCS Class 3
Stability Light Sensitive
InChI InChI=1S/C8H15N7O2S3/c9-6(15-20(12,16)17)1-2-18-3-5-4-19-8(13-5)14-7(10)11/h4H,1-3H2,(H2,9,15)(H2,12,16,17)(H4,10,11,13,14)
InChIKey XUFQPHANEAPEMJ-UHFFFAOYSA-N
SMILES C(NS(N)(=O)=O)(=N)CCSCC1=CSC(NC(N)=N)=N1
CAS DataBase Reference 76824-35-6(CAS DataBase Reference)
EPA Substance Registry System Propanimidamide, 3-[[[2-[(aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)- (76824-35-6)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H303
Precautionary statements  P270-P301+P312-P403-P501c
Hazard Codes  T
Risk Statements  20/21/22-45-61
Safety Statements  22-24/25-53-45-36/37/39
WGK Germany  2
RTECS  UA2300000
HS Code  29341000
Toxicity LD50 i.v. in mice: 244.4 mg/kg (Yasufumi)
NFPA 704
0
3 0

Famotidine price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) F6889 Famotidine 76824-35-6 500MG ₹7436.78 2022-06-14 Buy
Sigma-Aldrich(India) PHR1055 Famotidine Pharmaceutical Secondary Standard; Certified Reference Material 76824-35-6 1G ₹8465.15 2022-06-14 Buy
Sigma-Aldrich(India) F6889 Famotidine 76824-35-6 1G ₹13271.45 2022-06-14 Buy
Sigma-Aldrich(India) F6889 Famotidine 76824-35-6 5G ₹51732.68 2022-06-14 Buy
TCI Chemicals (India) F0530 Famotidine 76824-35-6 5G ₹9600 2022-05-26 Buy
Product number Packaging Price Buy
F6889 500MG ₹7436.78 Buy
PHR1055 1G ₹8465.15 Buy
F6889 1G ₹13271.45 Buy
F6889 5G ₹51732.68 Buy
F0530 5G ₹9600 Buy

Famotidine Chemical Properties,Uses,Production

Description

Famotidine is a competitive histamine H2-receptor antagonist, and the main pharmacodynamic effect of famotidine is to cause the inhibition of gastric secretion. Famotidine on decomposition releases toxic products such as carbon oxides (CO, CO2), nitrogen oxides (NO, NO2), and sulphur oxides (SO2, SO3). Famotidine is a medication that is available both in prescription and over-the-counter forms. It is used to treat conditions related to the oesophagus, stomach, and intestines. Some specific famotidine is used for the treatment of duodenal ulcers, gastric ulcers (stomach ulcers), gastroesophageal reflux disease (GERD), and pathological hypersecretory conditions that occur when stomach acid is secreted/ produced in very large quantities, an abnormal health condition called ‘Zollinger-Ellison syndrome’.

Chemical Properties

White Powder

Uses

Contact dermatitis from famotidine, a H2 -receptor agonist, was described in a nurse. In industry, three cases were reported due to intermediates of synthesis, 2- diamino-ethylene-amino-thiazolyl-methylenethiourea-dichloride and 4-chloromethyl-2-guanidinothiazolenitrochloride.

General Description

Famotidine is a histamine H2-receptor antagonist, which promotes the healing of erosive esophagitis, gastric and duodenal ulcers since it inhibits the gastric acid secretion in humans.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Contact allergens

Contact dermatitis in a nurse from famotidine, an H2-receptor agonist, was described. In industry, three cases were reported due to intermediates of the synthesis of 2-diamino-ethylene-amino-thiazolyl-methylenethio urea-dichloride, and 4-chloromethyl-2-guanidinothiaz ole-nitrochloride.

Clinical Use

Famotidine is a histamine H2-antagonist more potent than cimetidine and ranitidine. Administered once or twice daily, it is useful in the treatment of gastric, duodenal and anastomotic ulcers, upper gastrointestinal tract hemorrhage, reflux esophagitis and Zollinger-Ellison syndrome. Like ranitidine, it is lacking in antiandrogenic effects.

Famotidine Preparation Products And Raw materials

Raw materials

4-(CHLOROMETHYL)THIAZOLE HYDROCHLORIDE Amidinothiourea Sulfamide 1,3-Dichloroacetone Sodium hydroxide
Hydrochloric acid 3-Chloropropiononitrile
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Preparation Products

FaMotidine AMide IMpurity

Famotidine Suppliers

Global( 677)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CHEMXTREE STANDARDS +919872732255 Punjab, India 96 58 Inquiry
THE MOLECULEZ +91-7506703683 +91-7506703683 Maharashtra, India 79 58 Inquiry
ANWITA APIS +919000311012 Hyderabad, India 198 58 Inquiry
Dr. Reddy's Laboratories Ltd +91-4049002900 +91-4049002900 Hyderabad, India 165 58 Inquiry
J S LABS +91-7330612784 +91-7330612784 Tamil Nadu, India 160 58 Inquiry
Gonane Pharma +91-9819380043 +91-9819380043 NaviMumbai, India 192 58 Inquiry
Meenaakshi Molecules Pvt Ltd +91-9121311126 +91-9121311126 Telangana, India 45 58 Inquiry
Alembic Pharmaceuticals Limited +91-2652280880 +91-2652280550 Gujarat, India 115 58 Inquiry
Vivimed Labs Ltd +914066086608 Telangana, India 61 58 Inquiry
Hem-Deep Organics Pvt. Ltd. (HOPL) +91-9998689897 +91-9824114578 Gujarat, India 12 58 Inquiry
Supplier Advantage
CHEMXTREE STANDARDS 58
THE MOLECULEZ 58
ANWITA APIS 58
Dr. Reddy's Laboratories Ltd 58
J S LABS 58
Gonane Pharma 58
Meenaakshi Molecules Pvt Ltd 58
Alembic Pharmaceuticals Limited 58
Vivimed Labs Ltd 58
Hem-Deep Organics Pvt. Ltd. (HOPL) 58

Related articles

Famotidine Spectrum

Famotidine(76824-35-6)MS

76824-35-6(Famotidine)Related Search:

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Basic Violet 1 Methyl salicylate METSULFURON METHYL N-Aminothiourea
Sodium thiosulfate Sulfamide Thioacetamide Tribenuron methyl Sulfanilamide
Kresoxim-methyl Methyl acrylate N-Acetylsulfanilyl chloride Methanol Benzothiazole
Methylparaben Methyl [3-[[[2-(DiaMinoMethyleneaMino)-4-thiazolyl]Methyl]thio]propionyl]sulfaMide Hydrochloride (FaMotidine IMpurity)
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FAMOTIDINE [amino-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]-methyl]thio]propylidene]s 3-(((2-((aminoiminomethyl)amino)-4-thiazolyl)methyl)thio)-n-(aminosulfonyl)p 3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)-n(sup2)-sulfamoylp Famotidine USP&BP FAMOTIDINE, IMP. A (EP) AS HYDROCHLORIDE: 3-[[[2-[DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]-SULPHANYL]PROPANIMIDAMIDE HYDROCHLORIDE MM(CRM STANDARD) FAMOTIDINE, IMPURITY C BP STANDARD FAMOTIDINE, IMP. B (EP) AS DIMALONATE: 3,5-[2-[[[2-[(DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]-SULPHANYL]ETHYL]-4H-1,2,4,6-THIATRIAZINE 1,1-DIOXIDE DIMALONATE MM(CRM STANDARD) FAMOTIDINE, IMPURITY B3,5-BIS[2-[[[2-[(DIAMINOMETHYLENE)AMINO] THIAZOL-4-YL]METHYL]THIO]-ETHYL]-4H-1,2,4,6-THIATRIAZINE1,1-DIOXIDE EP STANDARD FAMOTIDINE, IMP. G (PHARMEUROPA): AS MALEATE 3-[[[2-[(DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]SULPHANYL]-N-CYANO-PROPANIMIDAMIDE MALEATE MM(CRM STANDARD) FAMOTIDINE, USP STANDARD FAMOTIDINE, BP STANDARD FAMOTIDINE, SULPHOXIDE MALEATE MM(CRM STANDARD) FAMOTIDINE, IMP. E (PHARMEUROPA): BIS[2-[[2-[(DIAMINOMETHYLENE)AMINO]-THIAZOL-4-YL]METHYL]]-DISULPHIDE MM(CRM STANDARD) FAMOTIDINE, IMP. D (EP): 3-(2-DIAMINOMETHYLENAMINO-1,3-THIAZOL-4-YLMETHYL-SULPHANYL)PROPANAMIDE MM(CRM STANDARD) FAMOTIDINE, MM(CRM STANDARD) FAMOTIDINE, DEGRADATION IMPURITY 2 BP STANDARD FAMOTIDINE, IMP. C (EP): 3-(2-DIAMINOMETHYLENAMINO-1,3-THIAZOL-4-YLMETHYL-SULPHANYL)-N-SULPHAMOYLPROPANAMIDE MM(CRM STANDARD) FAMOTIDINE, IMPURITY A3-[[[2-[(DIAMINOMETHYLENE)AMINO]THIAZOL-4-YL]METHYL]-THIO]PROPANAMIDE EP STANDARD FAMOTIDINE, IMP. F (PHARMEUROPA): 3-(2-DIAMINOMETHYLEN-AMINO-1,3-THIAZOL-4-YLMETHYL-SULPHANYL)PROPIONIC ACID MM(CRM STANDARD) FAMOTIDINE, DEGRADATION IMPURITY 1 BP STANDARD FAMOTIDINE, EP STANDARD FAMOTIDINE ASSAY STANDARD BP(CRM STANDARD) Propanimidamide, 3-2-(aminoiminomethyl)amino-4-thiazolylmethylthio-N-(aminosulfonyl)- FAMOTIDINE,USP 3-[[2-(diaminomethylideneamino)-1,3-thiazol-4-yl]methylsulfanyl]-N'-sulfamoyl-propanimidamide N'-[AMINOSULFONYL]-3-[(2-[DIAMINOMETHYLENEAMINO]-4-THIAZOLYL)METHYLTHIO]-PROPANAMIDINE Famotidine (Patented-No Supply) [1-Amino-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propylidene]sulfamide 2-[4-[2-(amino-sulfamoylimino-methyl)ethylsulfanylmethyl]-1,3-thiazol-2-yl]guanidine 3-[[[2-[(AMINOIMINOMETHYL)AMINO]-4-THIAZOLYL]METHYL]THIO]-N-(AMINOSULFONYL)PROPANIMIDAMIDE 3-(2-GUANIDINOTHIAZOL-4-YLMETHYLTHIO)-N1-SULFAMOYLPROPIONAMIDE Amfamox Dispmmil Famodine Ifada Peptrax Ulcetrax YM-11170 3-[(2-Diaminomethyleneaminothiazol-4-yl)methylthio]-N-sulfamoylpropionamidine Dispromil N-(Aminosulfonyl)-3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]thio]propanimidamide Famotidine,N′-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine Famotidine (125 mg) Famotidine (125 mg)I0E0630.997mg/mg(dr) (Z)-3-(((2-((diaMinoMethylene)aMino)thiazol-4-yl)Methyl)thio)-N'-sulfaMoylpropaniMidaMide FaMotidine (Pepcid) aminosulfonyl)- dispronil famodil famosan famoxal fanosin fibonel ganor gaster gastridan gastridin