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Guanfacine

Guanfacine Structure
CAS No.
29110-47-2
Chemical Name:
Guanfacine
Synonyms
C07037;SPD503;SPD 503;SPD-503;Guanfacine;Guanfacine USP/EP/BP;Guanfacine free base;Guanfacine Solution, 100ppm;[(2,6-Dichlorophenyl)acetyl]guanidine;2-(2,6-Dichlorophenylacetyl)guanidine
CBNumber:
CB3875216
Molecular Formula:
C9H9Cl2N3O
Molecular Weight:
246.09
MOL File:
29110-47-2.mol
Modify Date:
2023/5/18 11:31:19

Guanfacine Properties

Melting point 227-230?C
Density 1.50±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Soluble in DMSO
form Powder
pka 11.92±0.46(Predicted)
BCS Class 1

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501

Guanfacine Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

Guanfacine centrally acting α-adrenoceptor agonist. Guanfacine is an antihypertensive.

General Description

Guanfacine is more selective for 2-receptors than isclonidine. Their mechanism of action is the same as that ofclonidine. Differences between clonidine and its twoanalogs are seen in their elimination half-life values and intheir metabolism and urinary excretion patterns. The eliminationhalf-life of clonidine ranges from 20 to 25 hours,whereas that for guanfacine is about 17 hours. Guanabenzhas the shortest DOA of these three agents, with a half-lifeof about 6 hours. Clonidine and guanfacine are excretedunchanged in the urine to the extent of 60% and 50%,respectively. Very little of guanabenz is excreted unchangedin the urine.

Guanfacine Preparation Products And Raw materials

Global( 80)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Harman Finochem Ltd +91-2226528080 +91-2226528080 Maharashtra, India 37 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-29-87569266 15319487004 China 2417 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd +86-029-89586680 +86-18192503167 China 9030 58 Inquiry
sgtlifesciences pvt ltd +8617013299288 China 12382 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
Guanfacine 1-(α-Oxo-2,6-dichlorophenethyl)guanidine 2-(2,6-Dichlorophenylacetyl)guanidine C07037 BenzeneacetaMide, N-(aMinoiMinoMethyl)-2,6-dichloro- [(2,6-Dichlorophenyl)acetyl]guanidine N-carbaMiMidoyl-2-(2,6-dichlorophenyl)acetaMide N-Amidino-2-[2,6-dichlorophenyl] acetamide Guanfacine Solution, 100ppm N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide Guanfacine USP/EP/BP Guanfacine free base SPD 503 SPD503 SPD-503 29110-47-2 C9H9Cl2N3O Amines Aromatics Intermediates & Fine Chemicals Pharmaceuticals