Dexmedetomidine
- CAS No.
- 113775-47-6
- Chemical Name:
- Dexmedetomidine
- Synonyms
- MPV 1440;d-Medetomidine;DEXMEDETOMIDINE;(S)-Medetomidine;(+)-Medetomidine;Dexmedetomidine D6;Medetomidine (S)-Isomer;Medetomidine Impurity 56;DexmedetomidineHclC13H16N2.Hcl;DexmedetomidineHclC13H16N2.Hcl USP/EP/BP
- CBNumber:
- CB41017166
- Molecular Formula:
- C13H16N2
- Molecular Weight:
- 200.28
- MOL File:
- 113775-47-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:07
| Melting point | 146-149°C |
|---|---|
| Boiling point | 381.9±11.0 °C(Predicted) |
| Density | 1.053±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Soluble in DMSO > 10 mM |
| form | Powder |
| pka | 13.89±0.10(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)/t11-/m0/s1 |
| InChIKey | CUHVIMMYOGQXCV-NSHDSACASA-N |
| SMILES | C1NC([C@H](C2=CC=CC(C)=C2C)C)=CN=1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H373-H317-H360 |
| Precautionary statements | P260-P314-P501-P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
Dexmedetomidine Chemical Properties,Uses,Production
Chemical Properties
White Solid
Uses
Dexmedetomidine is a sedative drug that has many benefits when given to children under anesthesia, such as improved pain relief and reduced agitation following their surgery. The FDA-approved indications for dexmedetomidine are sedation of intubated and mechanically ventilated patients in the intensive care unit (ICU) and peri-procedural (or peri-operative) sedation of non-intubated patients.
Definition
ChEBI: Dexmedetomidine is a medetomidine. It has a role as an alpha-adrenergic agonist, a non-narcotic analgesic, an analgesic and a sedative. It is an enantiomer of a levomedetomidine.
brand name
Precedex (Hospira).
Side effects
This drug is most commonly given to cause sedation, so extreme sedation/lethargy for a short period of time is an expected side effect. Pale gums and lowered heart and respiratory rates can occur. Rarely, vomiting, diarrhea, and collapse may occur. When injected into the muscle, this medication can cause temporary pain at the injection site.
Mode of action
The mechanism of action of dexmedetomidine is as an Adrenergic alpha2-Agonist. Dexmedetomidine selectively binds to presynaptic alpha-2 adrenoceptors located in the brain, thereby inhibiting the release of norepinephrine from synaptic vesicles. This leads to an inhibition of postsynaptic activation of adrenoceptors, which inhibit sympathetic activity, thereby leading to sedation and anxiolysis. The analgesic effect of this agent is mediated by binding to alpha-2 adrenoceptors in the spinal cord.
Dexmedetomidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Lifecare Laboratories Pvt. Ltd | +91-4023750123 +91-4023750123 | Hyderabad, India | 18 | 58 | Inquiry |
| Medchem Labs | +91-7288889564 +91-7288889555 | Telangana, India | 25 | 58 | Inquiry |
| Maithri Drugs Pvt Ltd | +91-9059204566 +91-9848881740 | Telangana, India | 64 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6761 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5873 | 58 | Inquiry |
| Xiamen Wonderful Bio Technology Co., Ltd. | +8613043004613 | China | 305 | 58 | Inquiry |
| CONTIDE BIOTECH CO.,LTD | +852-53358525 | China | 568 | 58 | Inquiry |