Dexmedetomidine hydrochloride
- CAS No.
- 145108-58-3
- Chemical Name:
- Dexmedetomidine hydrochloride
- Synonyms
- DEXMEDETOMIDINE HCL;Dexmedetomidine Hydrochloride Injection;Precedex;4-((s)-alpha,2,3-trimethylbenzyl)imidazole monohydrochloride;5-[(1S)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole hydrochloride;4-[(1r)-1-(2,3-dimethylphenyl)ethyl]-3h-imidazole hydrochloride;4-(S)-[1-(2,3-DIMETHYLPHENYL)ETHYL]-1 H-IMIDAZOLE MONOHY DROCHLORIDE (DEXMEDETOMIDINE HYDROCHLORIDE);CS-1397;DEMEDETOMIDINE HCL;Dexmedetomidine hydr
- CBNumber:
- CB3838381
- Molecular Formula:
- C13H17ClN2
- Molecular Weight:
- 236.74
- MOL File:
- 145108-58-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/6/17 17:42:23
| Melting point | 156.5-157.5° |
|---|---|
| alpha | +52.4° (c = 1 in water) |
| Density | 1.17 g/cm3 |
| storage temp. | 2-8°C |
| solubility | H2O: soluble20mg/mL, clear |
| form | powder |
| color | white to beige |
| optical activity | [α]/D +48 to +58°, c = 1 in H2O |
| Merck | 14,2946 |
| Stability | Hygroscopic |
| InChI | InChI=1/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/s3 |
| InChIKey | VPNGEIHDPSLNMU-MERQFXBCSA-N |
| SMILES | [C@@H](C1NC=NC=1)(C1C=CC=C(C)C=1C)C.Cl |&1:0,r| |
| CAS DataBase Reference | 145108-58-3(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NI5156750 | |||||||||
| HS Code | 2933290000 | |||||||||
| NFPA 704 |
|
Dexmedetomidine hydrochloride price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0956 | Dexmedetomidine hydrochloride ≥98% (HPLC) | 145108-58-3 | 10MG | ₹11528.63 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0956 | Dexmedetomidine hydrochloride ≥98% (HPLC) | 145108-58-3 | 50MG | ₹46515.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR2701 | Dexmedetomidine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material | 145108-58-3 | 500MG | ₹22764.98 | 2022-06-14 | Buy |
| TCI Chemicals (India) | D5062 | Dexmedetomidine Hydrochloride | 145108-58-3 | 20MG | ₹4100 | 2022-05-26 | Buy |
| TCI Chemicals (India) | D5062 | Dexmedetomidine Hydrochloride | 145108-58-3 | 100MG | ₹8000 | 2022-05-26 | Buy |
Dexmedetomidine hydrochloride Chemical Properties,Uses,Production
Description
Dexmedetomidine was launched in the US as an i.v. infusion for sedation of initially intubated and mechanically ventilated patients during treatment in an intensive care unit, This imidazole derivative is the (S)-enantiomer of medetomidine that can be obtained via fractional crystallization of the tartrate salt of the racemic mixture. Dexmedetomidine is a full agonist of α2 adrenoceptors with 1300-fold selectivity versus α1 compared to the less selective partial α2 agonist clonidine, a veterinary hypnotic. Dexmedetomidine is unique compared with currently available sedatives in that it provides sedation, analgesia and anxiolysis with the ability of patients to be easily awakened. Besides, it causes minimal respiratory depression unlike other available drugs such as benzodiazepines or opioids. Pharmacological studies in transgenic mice showed that the sedative, anesthetic and analgesic effects of dexmedetomidine are specifically due to the stimulation of the a2A subtype receptor. Like other α2 adrenoceptor agonists, dexmedetomidine can provoke hypotension and bradycardia probably because of its non-selective action on peripheral a2B subtype receptors in vascular smooth muscle. Dexmedetomidine is extensively metabolized into methyl and glucuronide conjugates which are mainly eliminated by renal excretion. It was found to be a CYP2D6 inhibitor but less potent than the clinically relevant standard quinidine.
Physical properties
Dexmedetomidine hydrochloride is a white or almost white powder that is freely soluble in water and has a pKa of 7.1.
Uses
Dexmedetomidine hydrochloride has been used to study its effects on primary neonatal rat cardiomyocytes under hypoxic/reoxygenation conditions. It has also been used to study the effects of dexmedetomidine pretreatment on lipopolysaccharide-induced acute lung injury in mice.
benefits
The chemical name of dexmedetomidine hydrochloride is (S) -4- [1- (2,3- 3,5-dimethylphenyl) ethyl] -1H- imidazole hydrochlorides. Dexmedetomidine hydrochloride has an anti-sympathetic town. The effect of quiet and analgesic, compared with U.S. support pyrimidine, with higher selectivity and a short half-life, can be clinically used for Intensive Care Therapy. Start intubation and calmness using a lung ventilator patient during treatment. Meanwhile, the medicine can also reduce narcotic consumption, improve hand incidence of hemodynamic stability, and reduce myocardial ischaemia in art.
Biological Activity
Active isomer of Medetomide (4-[1-(2,3-Dimethylphenyl)ethyl]-1H-imidazolehydrochloride ), a potent, highly selective α 2 -adrenoceptor agonist (K i values are 1.08 and 1750 nM for α 2 - and α 1 -adrenoceptors respectively). Displays greater selectivity over α 1 -adrenoceptors than clonidine and UK 14,304 (1620-, 220- and 300-fold respectively). Active in vivo ; displays hypotensive, bradycardic, sedative, anxiolytic, hypothermic and analgesic effects.
Side effects
Dexmedetomidine hydrochloride may cause serious side effects including: low or high blood pressure,slow heart rate, and abnormal heart rate.
Synthesis
In a 500mL round-bottomed flask, (S)-1 (18.6g, 93mmo1) is dissolved into 50mL dehydrated alcohol, and adding HC1/ ethanolic soln to adjust pH is 2～3, add THF solution 300mL, placement is spent the night, and now adularescent crystallization, filters, crude product is through ethyl acetate/ethyl alcohol recrystallization, filter, infrared drying oven is dried to obtain dexmedetomidine hydrochloride (20.1g, yield 91.5%).
Dexmedetomidine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Vanquest Pharma Pvt Ltd | +91-9920897640 +91-9920897640 | Mumbai, India | 36 | 58 | Inquiry |
| Deccan Nutraceuticals Pvt. Ltd | +91-9822641298 +91-9822641298 | Mumbai, India | 18 | 58 | Inquiry |
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| Mac Chem Products (India) Pvt Ltd (Naprod Group) | +91-9727753234 +91-7770016606 | Maharashtra, India | 37 | 58 | Inquiry |
| Sanvin Group of Companies (Pioneer Agro Industries) | +91-2261066638 +91-2261066600 | Maharashtra, India | 27 | 58 | Inquiry |
| Surajlok Chemicals Pvt Ltd (Neon Laboratories Ltd) | +91-2268107000 +91-9987232509 | Maharashtra, India | 30 | 58 | Inquiry |
| Bioaltus Laboratories Pvt Ltd | +91-2249744539 +91-9820139885 | Maharashtra, India | 34 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| CIPLA LIMITED | +91 22 24826000 | New Delhi, India | 72 | 58 | Inquiry |
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