Butenafine hydrochloride
- CAS No.
- 101827-46-7
- Chemical Name:
- Butenafine hydrochloride
- Synonyms
- BUTENAFINE HCL;kp-363;MentaX;Volley;Scorba;Meridam;Butenafine HCI;Butenafine Hydro;Butenafine hydrochL;Butenafine hydrochlo
- CBNumber:
- CB8256177
- Molecular Formula:
- C23H27N.ClH
- Molecular Weight:
- 353.93
- MOL File:
- 101827-46-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/15 17:55:00
| Melting point | 210-214°C |
|---|---|
| storage temp. | room temp |
| solubility | DMSO: ≥10mg/mL |
| form | powder |
| color | white to off-white |
| Merck | 14,1518 |
| InChI | InChI=1S/C23H27N.ClH/c1-23(2,3)21-14-12-18(13-15-21)16-24(4)17-20-10-7-9-19-8-5-6-11-22(19)20;/h5-15H,16-17H2,1-4H3;1H |
| InChIKey | LJBSAUIFGPSHCN-UHFFFAOYSA-N |
| SMILES | C12C=CC=CC=1C=CC=C2CN(C)CC1=CC=C(C(C)(C)C)C=C1.Cl |
| CAS DataBase Reference | 101827-46-7(CAS DataBase Reference) |
Butenafine hydrochloride price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | B5188 | Butenafine hydrochloride ≥98% (HPLC) | 101827-46-7 | 10MG | ₹8822.38 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | B5188 | Butenafine hydrochloride ≥98% (HPLC) | 101827-46-7 | 50MG | ₹35062.18 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B3293 | Butenafine Hydrochloride | 101827-46-7 | 1G | ₹5200 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B3293 | Butenafine Hydrochloride | 101827-46-7 | 5G | ₹14700 | 2022-05-26 | Buy |
Butenafine hydrochloride Chemical Properties,Uses,Production
Description
Butenafine hydrochloride is a new benzylamine antifungal which appears to block the squalene epoxidation step of sterol synthesis in fungi. Active against a broad spectrum of fungi, butenafine hydrochloride is more effective in a guinea-pig model of tinea pedis than clotrimazole, naftifine and tolnaftate. Its efficacy is partially attributed to its long retention time in the skin.
Chemical Properties
White Solid
Uses
Butenafine hydrochloride has been used as a standard in high-performance liquid chromatography (HPLC) method to determine butenafine hydrochloride in butenafine-loaded nanosponges.
Definition
ChEBI: The hydrochloride salt of butenafine. An inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in fungal cell membranes, it is used for treatment of dermatological fungal infections.
General Description
Butenafine hydrochloride is chemically known as N-4-tertbutylbenzyl-N-methyl-1-naphthalenemethylamine hydrochloride. Butenafine, a benzylamine derivative, is a new generation antimycotic compound. It is easily soluble in methanol, ethanol, dichloromethane, and chloroform, but not in water. The allyl radical in butenafine hydrochloride is substituted by a butylbenzyl group.
Side effects
Side Effects:
Blistering, burning, crusting, dryness, or flaking of the skin where the medicine is applied.
itching, scaling, severe redness, soreness, or swelling of the skin where the medicine is applied.
Butenafine hydrochloride Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Glenmark Pharmaceuticals Limited | +912240189999 | Maharashtra, India | 93 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Synergene Active Ingredients Pvt. Ltd. | +91-04023700774 +91-04023700774 | Telangana, India | 96 | 58 | Inquiry |
| Sai Prathyu Marketing | 91-9666672409 | Hyderabad, India | 162 | 58 | Inquiry |
| Shubham Pharmachem Pvt., Ltd. | 91-22-26354800 | Maharashtra, India | 97 | 58 | Inquiry |
| Innovative Synthetic Molecules | +91 40-24111684 | Hyderabad, India | 527 | 58 | Inquiry |
| Rawia International HealthCare Pvt. Ltd. | 91-22-26425001 | Maharashtra, India | 170 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Dazzle Corporation | 91-22-28878459 | Maharashtra, India | 209 | 58 | Inquiry |
| Medkem Laboratories | 91-40-23700606 | Andhra Pradesh, India | 297 | 58 | Inquiry |