Butenafine
- CAS No.
- 101828-21-1
- Chemical Name:
- Butenafine
- Synonyms
- But·Nafine;BUTENAFINE;Butenafine USP/EP/BP;4-tert-Butylbenzylmethyl 1-naphtylmethylamine;(4-tert-butylbenzyl)-methyl-(1-naphthylmethyl)amine;N-methyl-N-(4-methylbenzyl)-N-(1-naphthylmethyl)amine;N-(4-tert-Butylbenzyl)-N-methyl-1-naphthalenemethanamine;n-(p-tert-butylbenzyl)-n-methyl-1-naphthalenemethylamine;1-(4-tert-butylphenyl)-N-methyl-N-(naphthalen-1-ylmethyl)methanamine;n-methyl-n-(naphthalen-1-ylmethyl)-1-(4-tert-butylphenyl)methanamine
- CBNumber:
- CB1742475
- Molecular Formula:
- C23H27N
- Molecular Weight:
- 317.47
- MOL File:
- 101828-21-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/3/16 7:03:48
| Melting point | 200-202 °C |
|---|---|
| Boiling point | 426.1±14.0 °C(Predicted) |
| Density | 1.032±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 63 mg/mL (198.44 mM);Ethanol: 63 mg/mL (198.44 mM) |
| pka | 7.87±0.50(Predicted) |
| Water Solubility | Water: Insoluble |
| LogP | 6.770 (est) |
| CAS DataBase Reference | 101828-21-1(CAS DataBase Reference) |
Butenafine Chemical Properties,Uses,Production
Uses
Butenafine (Mentax) is a synthetic benzylamine antifungal agent, related structurally and pharmacologically to terbinafine. It is thought to act by inhibiting the enzyme squalene 2,3-epoxidase, resulting in decreased ergosterol and corresponding increase in squalene, with subsequent cell membrane permeability alteration and cell death. It is active against dermatophytes, yeast, and Sporothrix.
Definition
ChEBI: Trimethylamine in which hydrogen atoms attached to different methyl groups are substituted by 1-naphthyl and 4-tert-butylphenyl groups. It is an inhibitor of squalene epoxidase, an enzyme responsible for the creation of sterols needed in funga cell membranes, and is used as its hydrochloride salt for treatment of dermatological fungal infections.
brand name
Lotrimin (Schering); Mentax (Mylan Bertek).
Butenafine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Unitrade Agencies | 08048372548Ext 632 | Mumbai, India | 197 | 58 | Inquiry |
| Sigma Audley | +86-15937194204 +86-18126314766 | China | 491 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24330 | 58 | Inquiry |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | China | 9320 | 58 | Inquiry |
| Hong Kong Excellence Biotechnology Co., Ltd. | China | 882 | 58 | Inquiry | |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry |