Tolnaftate
- CAS No.
- 2398-96-1
- Chemical Name:
- Tolnaftate
- Synonyms
- TOLNAFTATE USP;Tolnaflate;Aftate;Pitrex;sorgoa;Tritin;Focusan;Timoped;Tinavet;naftate
- CBNumber:
- CB4396231
- Molecular Formula:
- C19H17NOS
- Molecular Weight:
- 307.41
- MOL File:
- 2398-96-1.mol
- Modify Date:
- 2024/8/21 22:41:43
| Melting point | 110.5-111.5°C |
|---|---|
| Boiling point | 453.4±38.0 °C(Predicted) |
| Density | 1.1328 (rough estimate) |
| refractive index | 1.6970 (estimate) |
| storage temp. | Sealed in dry,2-8°C |
| solubility | Soluble in chloroform at 50 mg/ml. Sparingly soluble in ethanol or methanol |
| form | powder |
| pka | -0.35±0.50(Predicted) |
| color | white to off-white |
| Water Solubility | <0.1 g/100 mL at 22 ºC |
| λmax | 258nm(MeOH)(lit.) |
| Merck | 14,9519 |
| InChIKey | FUSNMLFNXJSCDI-UHFFFAOYSA-N |
| LogP | 5.142 (est) |
| NIST Chemistry Reference | Tolnaftate(2398-96-1) |
| EPA Substance Registry System | Tolnaftate (2398-96-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | FD8891300 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 2930206050 | |||||||||
| Toxicity | LD50 in mice, rats (g/kg): >10, >6 orally; >6, >4 s.c. (Hashimoto) | |||||||||
| NFPA 704 |
|
Tolnaftate price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T6638 | Tolnaftate | 2398-96-1 | 1G | ₹6419.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T6638 | Tolnaftate | 2398-96-1 | 5G | ₹17255.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | PHR1778 | Tolnaftate Pharmaceutical Secondary Standard; Certified Reference Material | 2398-96-1 | 1G | ₹21812.38 | 2022-06-14 | Buy |
| TCI Chemicals (India) | T3059 | Tolnaftate | 2398-96-1 | 1G | ₹3900 | 2022-05-26 | Buy |
| TCI Chemicals (India) | T3059 | Tolnaftate | 2398-96-1 | 5G | ₹9000 | 2022-05-26 | Buy |
Tolnaftate Chemical Properties,Uses,Production
Description
Tolnaftate is a thiocarbamate antifungal agent. It is active against clinical isolates of the dermatophytes T. rubrum, T. mentagraphytes, T. verrucosum, E. floccosum, and M. canis (MIC50s = 50, 100, 6, 50, and 50 ng/ml, respectively), as well as 18 additional yeast and filamentous fungi species (MIC = 0.003-0.8 μg/ml)., Tolnaftate also reduces aflatoxin production in A. parasiticus in a concentration-dependent manner. It inhibits squalene epoxidase with an IC50 value of 12.5 μg/ml in a cell-free assay.
Chemical Properties
White Solid
Uses
antifungal for cutaneous infections.
Tolnaftate (Aftate, Tinactin, etc.) is an odorless and nonstaining synthetic antifungal agent whose exact mechanism of action is unknown. It is effective against dermatophytes and P. orbiculare and Pityrosporum ovale. It is ineffective against C. albicans and bacteria.
Definition
ChEBI: A monothiocarbamic ester that is the methyl(3-tolyl)carbamothioate ester of 2-naphthol. A synthetic anti-fungal agent used to treat jock itch, athlete's foot and ringworm.
Indications
Tolnaftate (Aftate, Tinactin, etc.) is an odorless and nonstaining synthetic antifungal agent whose exact mechanism of action is unknown. It is effective against dermatophytes and P. orbiculare and Pityrosporum ovale. It is ineffective against C. albicans and bacteria.
General Description
Crystals or white powder.
Air & Water Reactions
Thio and dithiocarbamates slowly decompose in aqueous solution to form carbon disulfide and methylamine or other amines. Such decompositions are accelerated by acids. Insoluble in water.
Reactivity Profile
Tolnaftate is a thiocarbamate. Flammable gases are generated by the combination of thiocarbamates and dithiocarbamates with aldehydes, nitrides, and hydrides. Thiocarbamates and dithiocarbamates are incompatible with acids, peroxides, and acid halides.
Health Hazard
SYMPTOMS: In susceptible persons, Tolnaftate may cause sensitization or irritation.
Fire Hazard
Flash point data on Tolnaftate are not available, Tolnaftate is probably combustible.
Clinical Use
O,2-Naphthyl m,N-dimethylthiocarbanilate (Tinactin,Aftate, NP-27) is a white crystalline solid that is insoluble inwater, sparingly soluble in alcohol, and soluble in most organicsolvents. The compound, a thioester of β-naphthol, isfungicidal against dermatophytes, such as Trichophyton,Microsporum, and Epidermophyton spp., that cause superficialtinea infections. Tolnaftate is available in a concentrationof 1% in creams, powders, aerosols, gels, and solutionsfor the treatment of ringworm, jock itch, and athlete’s foot.Tolnaftate has been shown to act as an inhibitor of squaleneepoxidase in susceptible fungi, so it is classified with theallylamine antimycotics. Tolnaftate is formulated into preparationsintended to be used with artificial fingernails to counteractthe increased chance of ringworm of the nail beds.
Safety Profile
Mtldly toxic by ingestion. An experimental teratogen. When heated to decomposition it emits toxic fumes of SOx and NOx. A fungicide used to control athlete's foot. See also ESTERS and CARBAMATES.
Tolnaftate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| GRINDLAYS PHARMACEUTICALS PRIVATE LIMITED | +91-91-22-25278801 +91-2225278801 | Mumbai, India | 83 | 58 | Inquiry |
| Unilab Company | +91-912228260263 +91-63917864522 | Tamil Nadu, India | 43 | 58 | Inquiry |
| CNS CHEMICALS | +91-9381957258 +91-9381957258 | Telangana, India | 354 | 58 | Inquiry |
| Souvin Pharmaceuticals Pvt Ltd | +91-8983015895 +91-8983015895 | Maharashtra, India | 9 | 58 | Inquiry |
| Shimoga Chemicals | +91-9423565742 +91-9423565743 | Maharashtra, India | 10 | 58 | Inquiry |
| Aarti Drugs Ltd (part of Aarti Group of Industries) | +91-2224019025 +91-9136988221 | Maharashtra, India | 57 | 58 | Inquiry |
| Omshri Labs Pvt Ltd | +91-7977270534 +91-9833689647 | Maharashtra, India | 46 | 58 | Inquiry |
| Medilink Pharmachem | +91 (79) 3007-0133 | New Delhi, India | 424 | 50 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| Festiva Pharma | 08048372775Ext 728 | Gujarat, India | 238 | 58 | Inquiry |
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