2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Structure
CAS No.
526-36-3
Chemical Name:
2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE
Synonyms
Otrix;Otriven;Otrivin;Ba-11391;Otrivine;Rhinoxilin;XYLOMETAZOLINE;Xylomethazoline;AKOS BBS-00000259;XYLOMETAZOLINEANDITSHYDROCHLORIDE
CBNumber:
CB0759137
Molecular Formula:
C16H24N2
Molecular Weight:
244.38
MOL File:
526-36-3.mol
MSDS File:
SDS
Modify Date:
2023/5/21 10:59:17

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Properties

Melting point 131-133°
Boiling point 394.2±21.0 °C(Predicted)
Density 1.00±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: 49 mg/mL (200.51 mM);Ethanol: 49 mg/mL (200.51 mM)
pka pKa 10.6±0.1(H2O t = 22.0) (Uncertain)
Water Solubility Water: Insoluble
CAS DataBase Reference 526-36-3

SAFETY

Risk and Safety Statements

Toxicity LD50 oral in mouse: 215mg/kg

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Chemical Properties,Uses,Production

Uses

Adrenergic (vasoconstrictor).

brand name

Neo-Synephrine II (Sterling Winthrop); Otrivin Hydrochloride (Ciba-Geigy).

Synthesis

Xylometazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazoline (11.1.40), is also synthesized in a single reaction by cyclocondensation of 4-tert-butyl-2,6- dimethylbenzylcyanide with ethylendiamine [43,44].

Synthesis_526-36-3

2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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Zhuoer Chemical Co., Ltd 02120970332; +8613524231522 China 3005 58 Inquiry
XYLOMETAZOLINE 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE AKOS BBS-00000259 XYLOMETAZOLINEANDITSHYDROCHLORIDE Xylometazoline (base and/or unspecified salts) 1h-imidazole,2-((4-(1,1-dimethylethyl)-2,6-dimethylphenyl)methyl)-4,5-dihydr 2-(4-tert-butyl-2,6-dimethylbenzyl)-2-imidazolin 2-(4-tert-Butyl-2,6-dimethylbenzyl)-2-imidazoline 2-[[4-(1,1-Dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1H-imidazole 2-Imidazoline, 2-(4-tert-butyl-2,6-dimethylbenzyl)- Ba-11391 Otriven Otrivin Otrivine Otrix Xylomethazoline 1H-Imidazole,2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro- ORGANIC CHEMICAL - XYLOMETAZOLINE HYDROCHLOROTHIAZIDE Oxymetazoline Impurity 2(Oxymetazoline EP Impurity B) 2-[(4-tert-butyl-2,6-dimethylphenyl)methyl]-4,5-dihydro-1H-imidazole 2-(4-TERT-BUTYL-2,6-DIMETHYL-BENZYL)-4,5-DIHYDRO-1H-IMIDAZOLE USP/EP/BP Rhinoxilin 2-[[4-(1,1-dimethylethyl)-2,6-dimethylphenyl]methyl]-4,5-dihydro-1h-imidazole(xylometazoline), 526-36-3