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Azelastine

CAS No.: 58581-89-8

Chemical Name:: Azelastine

Synonyms: -4-yl)-;AZELASTINE;SPBio_000657;KBio3_002992;CAS 790307-93-0;Azelastine base;Spectrum3_001984;Spectrum2_000649;Azeptin：Rhino1ast;Azelastine USP/EP/BP

CBNumber:: CB6256007

Molecular Formula:: C22H24ClN3O

Molecular Weight:: 381.9

MOL File:: 58581-89-8.mol

Modify Date:: 2024/3/19 15:37:50

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Azelastine Properties

Melting point	111 - 115°C
Boiling point	533.9±60.0 °C(Predicted)
Density	1.1505 (rough estimate)
refractive index	1.5790 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly, Heated), Methanol (Slightly)
pka	pKa 9.82(H2O t=25 I=0.025) (Uncertain)
form	Solid
color	White to Off-White
BCS Class	1?
Stability	Stable under recommended storage conditions., Stable Under Recommended Storage C
CAS DataBase Reference	58581-89-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H312-H302-H335-H332
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501-P264-P270-P301+P312-P330-P501
Toxicity	LD50 orl-rat: 310 mg/kg ARZNAD 31,1184,81

Azelastine Chemical Properties,Uses,Production

Uses

anesthetic, anticonvulsant

Definition

ChEBI: A phthalazine compound having an oxo substituent at the 1-position, a 1-methylazepan-4-yl group at the 2-position and a 4-chlorobenzyl substituent at the 4-position.

Clinical Use

Azelastine, although not a close structural analogue to the benzimidazoles, has some structural similarities to them. It is used as a nasal spray for allergic rhinitis and as eye drops for allergic conjunctivitis.Like olopatadine, azelastine also stabilizes mast cells, preventing degranulation and subsequent release of histamine, leukotrienes, and PGD2. It is available in Europe for systemic use in the treatment of asthma and seasonal allergies. Besides antihistaminic effects, it also may block release of histamine and other inflammatory mediators from mast cells. When administered orally, the N-dealkylated metabolite appears to contribute significantly to its pharmacological effects.

Safety Profile

Poison by ingestion,subcutaneous, intravenous, and intraperitoneal routes.Experimental reproductive effects. When heated todecomposition it emits toxic fumes of NOx and Cl^- .

Azelastine Preparation Products And Raw materials

Raw materials

3-METHOXYPROPIONIC ACID 1-Methylpyrrolidine 4-(4-Chloro-benzyl)-2H-phthalazin-1-one Hydrazine sulfate Diphenylmethane

Acetophenone

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Preparation Products

Azelastine Suppliers

Global( 147)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Anant Pharmaceuticals Pvt Ltd	+91-8550986868 +91-9485998001	Haryana, India	461	58	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Unitrade Agencies	08048372548Ext 632	Mumbai, India	197	58	Inquiry
Triveni chemicals	08048762458	New Delhi, India	6093	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	China	21675	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29900	58	Inquiry

Supplier	Advantage
Anant Pharmaceuticals Pvt Ltd	58
Ralington Pharma	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Unitrade Agencies	58
Triveni chemicals	58
Pharma Affiliates	58
Henan Tianfu Chemical Co.,Ltd.	55
career henan chemical co	58

Azelastine Spectrum

Azelastine(58581-89-8)¹HNMR

58581-89-8(Azelastine)Related Search:

METHYL THIOPHENE-2-CARBOXYLATE Methyl acetate Methylparaben Methyl acrylate 2,6-DIMETHYLNAPHTHALENE

2-Methylnaphthalene Bensulfuron methyl Thiophanate-methyl 1-AdaMantanethylaMine Kresoxim-methyl

DBU Chlorodimethylphenylsilane Triphenylphosphine Methyl Phenylacetone

Sibutramine hydrochloride Parathion-methyl AZELASTINE HCL,AZELASTINE HYDROCHLORIDE

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1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin 4-(p-chlorobenzyl)-2-(hexahydro-1-methyl-1h-azepin-4-yl)-1-(2h)-phthalazinon 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride 4-(4-chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1-one 4-[(4-chlorophenyl)methyl]-2-(1-methyl-4-azepanyl)-1-phthalazinone 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one Azelastinum [INN-Latin] KBio3_002992 SPBio_000657 Spectrum2_000649 Spectrum3_001984 -4-yl)- AZELASTINE 1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)- 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)-phthalazin-1-one CAS 790307-93-0 Azeptin：Rhino1ast 2-(Hexahydro-1-methyl-1H-azepin-4-yl)-4-[(4-chlorophenyl)methyl]phthalazin-1(2H)-one 4-(p-Chlorobenzyl)-2-(1-methylhexahydro-1H-azepin-4-yl)phthalazin-1(2H)-one 4-(p-Chlorobenzyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Azelastine & Azelastine Hydrochloride Azelastine base 4-[(4-chlorophenyl)Methyl]-2-[(4S)-1-Methylazepan-4-yl]-1,2-dihydrophthalazin-1-one 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-y1)-1(2H)-phthalazinone 4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one 4-((4-Chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2 4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methyl-4-azepanyl]-1-phthalazinone Azelastine USP/EP/BP Phenylpyruvic Acid Impurity 7 58581-89-8 53408-27-6 C22H26ClN3O TELAZOL API