Tolazoline
- CAS No.
- 59-98-3
- Chemical Name:
- Tolazoline
- Synonyms
- Vasodil;Vasimid;Artonil;Kasimid;Lambril;Priscol;Benzolin;ciba3259;Divascol;Imidalin
- CBNumber:
- CB0236054
- Molecular Formula:
- C10H12N2
- Molecular Weight:
- 160.22
- MOL File:
- 59-98-3.mol
- Modify Date:
- 2024/5/22 11:23:49
| Melting point | 66-69 °C(lit.) |
|---|---|
| Boiling point | 188°C/20mmHg(lit.) |
| Density | 1.0849 (rough estimate) |
| refractive index | 1.6392 (estimate) |
| storage temp. | 2-8°C |
| solubility | alcohol: freely soluble |
| pka | pKa 10.3(H2O t undefined I = 0.1) (Uncertain) |
| form | Solid |
| color | Crystals from pet ether |
| Merck | 14,9506 |
| CAS DataBase Reference | 59-98-3(CAS DataBase Reference) |
| NIST Chemistry Reference | 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)-(59-98-3) |
| EPA Substance Registry System | 1H-Imidazole, 4,5-dihydro-2-(phenylmethyl)- (59-98-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302+H312+H332-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 20/21/22-36/37/38 | |||||||||
| Safety Statements | 26-28-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | NJ1925000 | |||||||||
| HS Code | 2933299090 | |||||||||
| Toxicity | cyt-ham:lng 62,500 mg/L GMCRDC 27,95,81 | |||||||||
| NFPA 704 |
|
Tolazoline price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 293490 | 2-Benzylimidazoline 99% | 59-98-3 | 1G | ₹6505.83 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 293490 | 2-Benzylimidazoline 99% | 59-98-3 | 5G | ₹14029.2 | 2022-06-14 | Buy |
| TCI Chemicals (India) | B3806 | 2-Benzylimidazoline min. 97.0 % | 59-98-3 | 5G | ₹7500 | 2022-05-26 | Buy |
Tolazoline Chemical Properties,Uses,Production
Uses
Tolazoline is used for treating stable forms of pulmonary hypertension in newborns, and in cases where systemic arterial oxygenation cannot be achieved in the usual manner under careful observation of professionals.
Definition
ChEBI: A member of the class of imidazoles that is 4,5-dihydro-1H-imidazole substituted by a benzyl group.
General Description
2-Benzylimidazoline is an active vasodilator.
Pharmacology
Tolazoline is a weak, reversible α-adrenoblocker that lowers resistance of peripheral blood vessels and elevates venous capacity. However, it also exhibits β-adrenomimetic activity, which consists of the stimulation of cardiac work and is manifest as tachycardia, cholinergic activity, which consists of stimulation of the gastrointestinal tract, and histamine-like activity, which consists of stimulation of gastric secretion.
Safety Profile
Poison by ingestion,intraperitoneal, and intravenous routes. Mutation data reported. When heated to decomposition it emits toxicfumes of NOx.
Tolazoline Preparation Products And Raw materials
Tolazoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
| Shanghai Aladdin Biochemical Technology Co.,Ltd. | +86-18521732826 | China | 48467 | 58 | Inquiry |