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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Neuronal Signaling >Adrenergic Receptor agonists >Dexmedetomidine hydrochloride

Dexmedetomidine hydrochloride

Dexmedetomidine hydrochloride Structure
  • ₹4100 - ₹46515.03
  • Product name: Dexmedetomidine hydrochloride
  • CAS: 145108-58-3
  • MF: C13H17ClN2
  • MW: 236.74
  • EINECS:682-047-2
  • MDL Number:MFCD07772269
  • Synonyms:4-((S)-α,2,3-Trimethylbenzyl)imidazole monohydrochloride;DeMedetoMidine hydrochloride;(S)-4-(1-(2,3-diMethylphenyl)ethyl)-1H-iMidazole hydrochloride;1H-IMidazole,5-[(1S)-1-(2,3-diMethylphenyl)ethyl]-, hydrochloride (1:1);5-[(1S)-1-(2,3-dimethylphenyl)ethyl]-1H-imidazole,hydrochloride (1:1);Dexmedetomidine hydrochloride 4-((S)-alpha,2,3-Trimethylbenzyl)imidazole monohydrochloride;(S)-Medetomidine hydrochloride;Given dexmedetomidine hydrochloride
7 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)
  • ottokemi

Package

  • 10MG
  • 20MG
  • 50MG
  • 100MG
  • 500MG
  • ManufacturerTCI Chemicals (India)
  • Product numberD5062
  • Product descriptionDexmedetomidine Hydrochloride
  • Packaging20MG
  • Price₹4100
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberD5062
  • Product descriptionDexmedetomidine Hydrochloride
  • Packaging100MG
  • Price₹8000
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0956
  • Product descriptionDexmedetomidine hydrochloride ≥98% (HPLC)
  • Packaging10MG
  • Price₹11528.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPHR2701
  • Product descriptionDexmedetomidine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material
  • Packaging500MG
  • Price₹22764.98
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0956
  • Product descriptionDexmedetomidine hydrochloride ≥98% (HPLC)
  • Packaging50MG
  • Price₹46515.03
  • Updated2022-06-14
  • Buy
  • Manufacturerottokemi
  • Product number D 0425
  • Product descriptionDexmedetomidine hydrochloride 98%
  • Packaging10mg
  • Price₹10503
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number D 0425
  • Product descriptionDexmedetomidine hydrochloride 98%
  • Packaging50mg
  • Price₹42003
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) D5062 Dexmedetomidine Hydrochloride 20MG ₹4100 2022-05-26 Buy
TCI Chemicals (India) D5062 Dexmedetomidine Hydrochloride 100MG ₹8000 2022-05-26 Buy
Sigma-Aldrich(India) SML0956 Dexmedetomidine hydrochloride ≥98% (HPLC) 10MG ₹11528.63 2022-06-14 Buy
Sigma-Aldrich(India) PHR2701 Dexmedetomidine Hydrochloride Pharmaceutical Secondary Standard; Certified Reference Material 500MG ₹22764.98 2022-06-14 Buy
Sigma-Aldrich(India) SML0956 Dexmedetomidine hydrochloride ≥98% (HPLC) 50MG ₹46515.03 2022-06-14 Buy
ottokemi D 0425 Dexmedetomidine hydrochloride 98% 10mg ₹10503 2022-05-26 Buy
ottokemi D 0425 Dexmedetomidine hydrochloride 98% 50mg ₹42003 2022-05-26 Buy

Properties

Melting point :156.5-157.5°
alpha :+52.4° (c = 1 in water)
Density :1.17 g/cm3
storage temp. :2-8°C
solubility :H2O: soluble20mg/mL, clear
form :powder
color :white to beige
optical activity :[α]/D +48 to +58°, c = 1 in H2O
Merck :14,2946
Stability :Hygroscopic
InChI :InChI=1/C13H16N2.ClH/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13;/h4-8,11H,1-3H3,(H,14,15);1H/t11-;/s3
InChIKey :VPNGEIHDPSLNMU-MERQFXBCSA-N
SMILES :[C@@H](C1NC=NC=1)(C1C=CC=C(C)C=1C)C.Cl |&1:0,r|
CAS DataBase Reference :145108-58-3(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Dexmedetomidine is the (S)-enantiomer of medetomidine, an imidazole compound that binds to α2-adrenoceptors (Ki = 1.08 nM) with high affinity and selectivity compared to that of α1-adrenoceptors (Ki = 1.8 μM). Dexmedetomidine produces analgesic, sedative, and anxiolytic effects through both presynaptic activation of α2-adrenoceptors, which inhibits norepinephrine release, and postsynaptic activation of α2-adrenoceptors, which inhibits sympathetic activity and decreases blood pressure and heart rate.

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