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ChemicalBook > Product Catalogue >API >Nervous system drugs >Drug Metabolism in Human Brain >Donepezil

Donepezil

Donepezil Structure
  • ₹0
  • Product name: Donepezil
  • CAS: 120014-06-4
  • MF: C24H29NO3
  • MW: 379.49
  • EINECS:601-651-9
  • MDL Number:MFCD00912833
  • Synonyms:DONEPEZIL;AKOS 226-23;n-1-one ;2-[(1-benzyl-4-piperidyl)methyl]-5,6-dimethoxy-2,3-dihydroinden-1-one;1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON-2-YL) METHYL] PIPERIDINE;2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, hydrate(1:1:1);Donepezil hydrochloride monohydrate;2-[(1-Benzyl-4-piper
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :207°C
Boiling point :527.9±50.0 °C(Predicted)
Density :1.141±0.06 g/cm3(Predicted)
storage temp. :Sealed in dry,Room Temperature
solubility :Acetone (Slightly), Chloroform (Slightly)
form :Solid
pka :8.84±0.10(Predicted)
color :White to Off-White
Water Solubility :2.931 mg/L
CAS DataBase Reference :120014-06-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Donepezil is a reversible acetylcholinesterase inhibitor that readily crosses the blood-brain barrier to reduce the breakdown of acetylcholine. It has a half-life in circulation of about 70 hours. As acetylcholine modulates plasticity, excitability, and arousal in the central nervous system, donepezil is commonly used in the treatment of Alzheimer’s disease to improve cognition, memory, and behavior. In this way, it is intended to prevent or reverse dementia. Studies on these effects have been equivocal, indicating that more research into the therapeutic potential of donepezil is warranted.

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Suppliers and manufacturers

Cadila Pharmaceuticals Ltd J S LABS Gonane Pharma Zydus Lifesciences Ltd. Besil Chem LLP Ralington Pharma Alfa Omega Pharma Ebenezer Industries BEC Chemicals Pvt Ltd Vijaya Pharma And Life Science