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ChemicalBook > Product Catalogue >API >Nervous system drugs >Antiparkinson Drugs >Memantine

Memantine

Memantine Structure
  • ₹0
  • Product name: Memantine
  • CAS: 19982-08-2
  • MF: C12H21N
  • MW: 179.3
  • EINECS:690-724-9
  • MDL Number:MFCD02114015
  • Synonyms:AKOS BB-9600;MEMANTINE;AURORA KA-7643;TIMTEC-BB SBB002574;3,5-dimethyladamantan-1-amine HCl;1-Amino-3,5-dimethyladamantane;3,5-Dimethyl-1-aminoadamantane;1,3-Dimethylaminoadamantane
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Melting point :258 °C
Boiling point :239.8±8.0 °C(Predicted)
Density :1.046
refractive index :nD25 1.4941
storage temp. :Keep in dark place,Inert atmosphere,2-8°C
solubility :Chloroform (Slightly), DMSO (Slightly)
form :Solid
pka :10.79±0.60(Predicted)
color :Colorless Oil to Off-White Waxy
BCS Class :1?
CAS DataBase Reference :19982-08-2(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330 Rinse mouth.
P501 Dispose of contents/container to..…

Description

Memantine is a potent antagonist of the N-methyl-D-aspartate (NMDA) receptor. Experimentally, memantine inhibits and reverses the abnor-mal activity of a protein phosphatase (PP-2A) that leads to tauhyperphosphorylation and to neurofibrillary degeneration inAD. Memantine is effective and well toler-ated in patients with severe AD and wasapproved by the FDA for the treatment of moderate-to-severe AD.

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