Aganodine
- CAS No.
- 86696-87-9
- Chemical Name:
- Aganodine
- Synonyms
- Aganodin;Aganodine;Guanidine, N-(4,7-dichloro-1,3-dihydro-2H-isoindol-2-yl)-
- CBNumber:
- CB41116865
- Molecular Formula:
- C9H10Cl2N4
- Molecular Weight:
- 245.112
- MOL File:
- 86696-87-9.mol
- Modify Date:
- 2022/12/21 16:56:50
Aganodine Chemical Properties,Uses,Production
Originator
Aganodine ,ZYF Pharm Chemical
Manufacturing Process
The solution of 3,6-dichlorophthalic anhydride in 300 ml of N,Ndimethylformamide
are heated to the boiling point over 15 min with tbutylcarbazate.
Subsequent to evaporation of the solvent, N-(tbutyloxycarbonylamino)-
3,6-dichlorophthalimide is obtained from ethanol.
The solution of N-(t-butyloxycarbonylamino)-3,6-dichlorophthalimide in 400 ml
of absolute tetrahydrofuran are slowly dripped into a suspension of aluminum
lithium hydride in absolute tetrahydrofuran. The mixture is heated to the
boiling point. Conventional processing yields N-(t-butyloxycarbonylamino)-4,7-
dichloroisoindoline.
N-(t-Butyloxycarbonylamino)-4,7-dichloroisoindoline are introduced into
concentrated hydrochloric acid and stirred at room temperature. The
hydrochloride of 2-amino-4,7-dichloroisoindoline precipitates in the form of
crystals is obtained, melting point 230°-232°C.
2-Amino-4,7-dichloroisoindoline hydrochloride and cyanamide are heated over
2 h to the boiling point in n-amyl alcohol. The solvent is evaporated off and
the residue recrystallized from isopropyl alcohol and ethyl ether, yielding the
(4,7-dichloroisoindolin-2-yl)guanidine in the form of hydrochloride, melting
point 235°-237°C.
To obtained the base (4,7-dichloroisoindolin-2-yl)guanidine the salt (4,7-
dichloroisoindolin-2-yl)guanidine hydrochloride is treated with sodium
bicarbonicum.
Therapeutic Function
Antihypertensive
Aganodine Preparation Products And Raw materials
Raw materials
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Aganodine Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
3B Scientific Corporation | 847.281.9822 | United States | 6744 | 47 | Inquiry |
2A PharmaChem USA | (630) 737-0988 | United States | 6148 | 39 | Inquiry |
Lanospharma Laboratories Co.,Ltd | 13440048448 | China | 6343 | 56 | Inquiry |
Leancare Ltd. | +33 962096793 | United Kingdom | 6460 | 42 | Inquiry |
TargetMol Chemicals Inc. | 4008200310 | China | 24017 | 58 | Inquiry |
Supplier | Advantage |
---|---|
TargetMol Chemicals Inc. | 58 |
3B Scientific Corporation | 47 |
2A PharmaChem USA | 39 |
Lanospharma Laboratories Co.,Ltd | 56 |
Leancare Ltd. | 42 |
TargetMol Chemicals Inc. | 58 |