Betadex Sulfobutyl Ether Sodium
- CAS No.
- 182410-00-0
- Chemical Name:
- Betadex Sulfobutyl Ether Sodium
- Synonyms
- SBE-β-CD;CAPTISOL;sodiuM salts;Sulfobutylether-β-Cyclodextrin;b-Cyclodextrin sulfobutyl ether sodium salt;β-Cyclodextrin, sulfobutyl ethers, sodium salts;SBEBCD;Sulfobutyl beta cyclodextrin;sulfobutyl ether B-cyclodextrin;Sulfobutyl Ether-beta-cyclodextrin Sodium Salt
- CBNumber:
- CB41208906
- Molecular Formula:
- C42H70O35
- Molecular Weight:
- 1134.9842
- MOL File:
- 182410-00-0.mol
- Modify Date:
- 2024/6/15 22:11:33
SAFETY
Risk and Safety Statements
| Signal word | Warning |
|---|---|
| Hazard statements | H317 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501 |
| HS Code | 2940006000 |
Betadex Sulfobutyl Ether Sodium price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ottokemi | S 7274 | Sulfobutyl ether beta-cyclodextrin sodium, 99% | 182410-00-0 | 1gm | ₹1809 | 2022-05-26 | Buy |
| ottokemi | S 7274 | Sulfobutyl ether beta-cyclodextrin sodium, 99% | 182410-00-0 | 5gm | ₹3906 | 2022-05-26 | Buy |
| ottokemi | S 7274 | Sulfobutyl ether beta-cyclodextrin sodium, 99% | 182410-00-0 | 25gm | ₹8649 | 2022-05-26 | Buy |
| ottokemi | S 7274 | Sulfobutyl ether beta-cyclodextrin sodium, 99% | 182410-00-0 | 100gm | ₹27009 | 2022-05-26 | Buy |
| ottokemi | S 7274 | Sulfobutyl ether beta-cyclodextrin sodium, 99% | 182410-00-0 | 1kg | ₹220599 | 2022-05-26 | Buy |
Betadex Sulfobutyl Ether Sodium Chemical Properties,Uses,Production
Chemical Properties
β-Cyclodextrin, sulfobutyl ethers, sodium salts is a cyclic oligosaccharide containing seven D-(t)- glucopyranose units attached by α(1→4) glucoside bonds. Sulfobutylether b-cyclodextrin is an anionic bcyclodextrin derivative with a sodium sulfonate salt separated from the hydrophobic cavity by a butyl spacer group. The substituent is introduced at positions 2, 3, and 6 in at least one of the glucopyranose units in the cyclodextrin structure. Introducing the sulfobutylether (SBE) into b-cyclodextrin can produce materials with different degrees of substitution, theoretically from 1 to 21; the hepta-substituted preparation (SBE7-b-CD) is the cyclodextrin with the most desirable drug carrier properties. Sulfobutylether b-cyclodextrin occurs as a white amorphous powder.
Production Methods
Sulfobutylether β-cyclodextrin is prepared by alkylation of bcyclodextrin using 1,4-butane sultone under basic conditions. The degree of substitution in b-cyclodextrin is controlled by the stoichiometric ratio of β-cyclodextrin to sultone used in the process.
Toxicity evaluation
Sulfobutylether b-cyclodextrin sodium (SBECD) has been associated with toxic effects in the kidney. Doses up to 1500 mg/kg produced no histopathological evidence of toxicity in dog kidneys.
Safety
Sulfobutylether b-cyclodextrin is derived from b-cyclodextrin,
which is nephrotoxic when administered parenterally.
However, studies have shown that sulfobutylether bcyclodextrin
is well tolerated at high doses, when administered via
intravenous bolus injections, orally, and by inhalation. Up to
9 g/day may be administered by IV infusion in a licensed
voriconazole formulation. The safety following high doses of
sulfobutylether β-cyclodextrin intravenous administration in
humans is continually being investigated.
Sulfobutylether β-cyclodextrin has been subjected to an extensive
battery of in vitro and in vivo genotoxicity and pharmacological
evaluations. No genotoxic or mutagenic changes were
observed with sulfobutylether β-cyclodextrin administration. Sulfobutylether
β-cyclodextrin is biocompatible and exhibits no
pharmacological activity. It is rapidly eliminated unmetabolized
when administered intravenously.
storage
Sulfobutylether b-cyclodextrin(182410-00-0) is stable in the solid state and should be protected from high humidity. It should be stored in a tightly sealed container in a cool, dry place.
It will reversibly take up moisture without any effect on the appearance of the material at humidities up to 60% RH. Equilibration at RH values above 60% will result in deliquescence. Once in this state, the material can be dried, but will give a glasslike product. This water absorption behavior is typical of amorphous hygroscopic materials.
Sulfobutylether b-cyclodextrin is stable in aqueous solutions at values above about pH 1. It can degrade in highly acidic (pH < 1) solutions, particularly at elevated temperatures, producing the ring-opened form, followed by hydrolysis of the a(1-4) glucoside bonds.
Sulfobutylether b-cyclodextrin solutions may be autoclaved.
Incompatibilities
The preservative activity of benzalkonium chloride is reduced in the presence of sulfobutylether b-cyclodextrin.
Regulatory Status
Sulfobutylether β-cyclodextrin is included in IV and IM injectable products currently approved and marketed in the USA, Europe, and Japan. It is included in the FDA Inactive Ingredients Database for IM and IV use. Its use by other routes, including SC, oral, inhalation, nasal and ophthalmic, is being evaluated in clinical studies.
Betadex Sulfobutyl Ether Sodium Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Gland Pharma Ltd | +91-7075736524 +91-9700602423 | Telangana, India | 44 | 58 | Inquiry |
| Panvo Organics Pvt Ltd | +91 9789806833 +91 9444351711 | Tamil Nadu, India | 23 | 58 | Inquiry |
| BIOPHORE INDIA PHARMACEUTICALS PVT LTD | +91-4047474545 | New Delhi, India | 105 | 58 | Inquiry |
| GLAND PHARMA LTD | +91-40-30510999 | New Delhi, India | 52 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| Reax Chemicals | 08048372701Ext 416 | Hyderabad, India | 4223 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Gland Pharma Ltd | 58 |
| Panvo Organics Pvt Ltd | 58 |
| BIOPHORE INDIA PHARMACEUTICALS PVT LTD | 58 |
| GLAND PHARMA LTD | 58 |
| A.J Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| Pharmaffiliates Analytics and Synthetics P. Ltd | 58 |
| Reax Chemicals | 58 |
| Clearsynth Labs | 58 |
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