(2-Hydroxypropyl)-γ-cyclodextrin
- CAS No.
- 128446-34-4
- Chemical Name:
- (2-Hydroxypropyl)-γ-cyclodextrin
- Synonyms
- HPGCD;HP-gamma-CD;CAVASOL(R)W8;Cavasol? W8 HP;Calcium Dobesilate Capsules;2-FLUORO-4-METHYL-1-NITROBENZENE;HydroxypropyI Gamma Cyclodextrin;(2-hydroxypropyl)-γ-cyclodextrin;(2-Hydroxypropyl)-γ-cyclodextrin,HGC;g-Cyclodextrin, 2-hydroxypropylethers
- CBNumber:
- CB8449476
- Molecular Formula:
- C48H80-nO40.(C3H7O)n
- Molecular Weight:
- 0
- MOL File:
- 128446-34-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
| Melting point | 52-55 °C(lit.) |
|---|---|
| Boiling point | 97-98 °C3 mm Hg(lit.) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: soluble450mg/mL |
| form | Solid powder |
| color | white |
| PH | 6-9 (2% in H2O) |
| optical activity | [α]20/D +145°, c = 1 in H2O |
| InChIKey | WZMOWQCNPFDWPA-UHFFFAOYSA-N |
| CAS DataBase Reference | 128446-34-4(CAS DataBase Reference) |
| Absorption |
≤1.7 at 220-350nm in solution at 2% ≤1.7 at 350-660nm in solution at 2% |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P302+P352-P305+P351+P338-P362+P364 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-36/37/38 |
| Safety Statements | 26-36/37 |
| WGK Germany | 3 |
| HS Code | 2940000080 |
(2-Hydroxypropyl)-γ-cyclodextrin price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | H125 | (2-Hydroxypropyl)-γ-cyclodextrin solid | 128446-34-4 | 5G | ₹11766.78 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | H125 | (2-Hydroxypropyl)-γ-cyclodextrin solid | 128446-34-4 | 100G | ₹86047.93 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 779229 | (2-Hydroxypropyl)-γ-cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science | 128446-34-4 | 100G | ₹45887.18 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 779229 | (2-Hydroxypropyl)-γ-cyclodextrin Produced by Wacker Chemie AG, Burghausen, Germany, Life Science | 128446-34-4 | 500G | ₹54926.05 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 390704 | (2-Hydroxypropyl)-γ-cyclodextrin extent of labeling: 0.6 molar substitution | 128446-34-4 | 5G | ₹4048.55 | 2022-06-14 | Buy |
(2-Hydroxypropyl)-γ-cyclodextrin Chemical Properties,Uses,Production
Chemical Properties
white powder
Uses
For R&D use
General Description
(2-Hydroxypropyl)-γ-cyclodextrin belongs to the class of cyclodextrin derivatives, which exhibit a greater extent of solubility in water compared to their parent compounds. It is widely used in parenteral formulations and solid dosage forms to aid in the improvement of their stability, dissolution, bioavailability, etc.
Biological Activity
(2-Hydroxypropyl)-γ-cyclodextrin (HPγCD) is a water-soluble alkylated cyclodextrin derivative. It has pharmaceutical potential as it may aid in enhancing the solubility of drugs for oral dosage preparations or formulations. It solubilizes macromolecules, such as cholesterol. It is like β cyclodextrin but solubilizes larger molecules. It favors lysosomes distribution across the cytoplasm and can modulate lysosomal dynamics and participates in lysosomal homeostasis. HPγCD treatment promotes a wide distribution of lysosomes across the cytoplasm in NPC1 patient-derived fibroblasts. In contrast, lysosomes are clustered near the cell center in untreated cells, raising the possibility that HPγCD has the potential to modulate lysosomal dynamics and functions[1]. In the Niemann pick disease model, HPγCD reduces cholesterol accumulation. Industrially produced HPγCD, which is used as a complexing agent in new ophthalmic formulations, is not a single compound but a heterogeneous, complex mixture of homologues and isomers substituted by a variable number of 2-hydroxy-propyl groups at different positions of the sugar moieties[2].
References
[1] Ashutosh Singhal. “2-Hydroxypropyl-gamma-cyclodextrin overcomes NPC1 deficiency by enhancing lysosome-ER association and autophagy.” Scientific Reports (2020): 8663.
[2] W Blum . "Determination of 2-hydroxypropyl-γ-cyclodextrin in plasma of cynomolgus monkeys after oral administration by gas chromatography–mass spectrometry.” Journal of Chromatography B: Biomedical Sciences and Applications 720 1 (1998): Pages 171-178.
(2-Hydroxypropyl)-γ-cyclodextrin Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6257 | 58 | Inquiry |
| Drug Mart Intermediates And Chemicals | 08048954865 | Gujarat, India | 56 | 58 | Inquiry |
| Sakshi Corporation | 07942539673 | Mumbai, India | 223 | 58 | Inquiry |
| Wuhan Fortuna Chemical Co.,Ltd | +8618007136271 | China | 5991 | 58 | Inquiry |
| Shanghai UCHEM Inc. | +862156762820 +86-13564624040 | China | 7906 | 58 | Inquiry |
| Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | China | 5868 | 58 | Inquiry |
| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | China | 5849 | 58 | Inquiry |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | China | 21628 | 55 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29859 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19552 | 58 | Inquiry |
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