β-Cyclodextrin
- CAS No.
- 7585-39-9
- Chemical Name:
- β-Cyclodextrin
- Synonyms
- β-Cyclodextrin;betadex;B-Cyclodextrin;Cyclodextrins;CARAWAY;BCD;BETA BYCLODEXTRIN;CYCLOMALTOHEPTAOSE;Β-CycIodextrin;Beta Chitosan
- CBNumber:
- CB8289713
- Molecular Formula:
- C42H70O35
- Molecular Weight:
- 1134.99
- MOL File:
- 7585-39-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/25 20:04:51
| Melting point | 290-300 °C (dec.) (lit.) |
|---|---|
| alpha | [α]D25 +159～+165° (c=1, H2O) (After Drying) |
| Boiling point | 844.96°C (rough estimate) |
| Density | 1.2296 (rough estimate) |
| refractive index | 1.7500 (estimate) |
| FEMA | 4028 | BETA-CYCLODEXTRIN |
| storage temp. | room temp |
| solubility | 1 M NaOH: 50 mg/mL |
| form | powder |
| pka | 11.73±0.70(Predicted) |
| color | white |
| PH | 5.0-8.0 (1% in solution, Ph Eur) |
| Odor | at 100.00 %. odorless |
| Odor Type | odorless |
| optical activity | [α]20/D +162±3°, c = 1.5% in H2O |
| Water Solubility | Soluble in water and ammonium hydroxide. |
| Merck | 14,2718 |
| BRN | 78623 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
| LogP | -9.06 |
| EPA Substance Registry System | .beta.-Cyclodextrin (7585-39-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H332 | |||||||||
| Precautionary statements | P261-P304+P340 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38-20 | |||||||||
| Safety Statements | 26-36-24/25 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | GU2293000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29400000 | |||||||||
| NFPA 704 |
|
β-Cyclodextrin price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W402826 | β-Cyclodextrin | 7585-39-9 | 1SAMPLE | ₹5141.88 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W402826 | β-Cyclodextrin | 7585-39-9 | 25G | ₹6624.9 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W402826 | β-Cyclodextrin | 7585-39-9 | 100G | ₹18683.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W402826 | β-Cyclodextrin | 7585-39-9 | 1KG | ₹57004.45 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | C4805 | β-Cyclodextrin powder, BioReagent, suitable for cell culture, ≥97% | 7585-39-9 | 5G | ₹4514.03 | 2022-06-14 | Buy |
β-Cyclodextrin Chemical Properties,Uses,Production
Chemical Properties
white powder
Occurrence
A derivative of naturally occurring starch.
Uses
β-Cyclodextrin is a cyclic oligosaccharide produced from starch via enzymatic conversion. β-Cyclodextrin is commonly used to produce HPLC columns allowing chiral enantiomers separation.
Preparation
Usually produced commercially from Bacillus macerans or B. circulans fermentation of starch or starch hydrolysate.
Production Methods
Cyclodextrins are manufactured by the enzymatic degradation of starch using specialized bacteria. For example, β-cyclodextrin is produced by the action of the enzyme cyclodextrin glucosyltransferase upon starch or a starch hydrolysate. An organic solvent is used to direct the reaction that produces β-cyclodextrin, and to prevent the growth of microorganisms during the enzymatic reaction. The insoluble complex of β-cyclodextrin and organic solvent is separated from the noncyclic starch, and the organic solvent is removed in vacuo so that less than 1 ppm of solvent remains in the β-cyclodextrin. The β-cyclodextrin is then carbon treated and crystallized from water, dried, and collected.
Essential oil composition
In addition to carvone, the oil contains d-limonene, carveol, diacetyl furfural, methyl alcohol, acetic aldehyde and other substances. Caraway oil consists of 3.5 to 7% volatile and fatty oils; resin, sugar, tannin, mucilage.
General Description
Beta-Cyclodextrin is the most abundant and cheap cyclic oligosaccharide that forms inclusion complexes with several drug molecules. Its main application is in tablet and capsule formulations.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Safety
Cyclodextrins are starch derivatives and are mainly used in oral and
parenteral pharmaceutical formulations. They are also used in
topical and ophthalmic formulations.
Cyclodextrins are also used in cosmetics and food products, and
are generally regarded as essentially nontoxic and nonirritant
materials. However, when administered parenterally, β-cyclodextrin
is not metabolized but accumulates in the kidneys as insoluble
cholesterol complexes, resulting in severe nephrotoxicity.
Cyclodextrin administered orally is metabolized by microflora in
the colon, forming the metabolites maltodextrin, maltose, and
glucose; these are themselves further metabolized before being
finally excreted as carbon dioxide and water. Although a study
published in 1957 suggested that orally administered cyclodextrins
were highly toxic, more recent animal toxicity studies in rats and
dogs have shown this not to be the case, and cyclodextrins are now
approved for use in food products and orally administered
pharmaceuticals in a number of countries.
Cyclodextrins are not irritant to the skin and eyes, or upon
inhalation. There is also no evidence to suggest that cyclodextrins
are mutagenic or teratogenic.
β-Cyclodextrin
LD50 (mouse, IP): 0.33 g/kg(16)
LD50 (mouse, SC): 0.41 g/kg
LD50 (rat, IP): 0.36 g/kg
LD50 (rat, IV): 1.0 g/kg
LD50 (rat, oral): 18.8 g/kg
LD50 (rat, SC): 3.7 g/kg
storage
Cyclodextrins should be stored in a tightly sealed container, in a cool, dry place.Cyclodextrins are stable in the solid state if protected from high humidity.
Purification Methods
Recrystallise β-cyclodextrin from water and dry it for 12hours in a vacuum at 110o, or 24hours in a vacuum at 70o. The purity is assessed by TLC on cellulose containing a fluorescent indicator. [Taguchi, J Am Chem Soc 108 2705 1986, Tabushi et al. J Am Chem Soc 108 4514 1986, Orstam & Ross J Phys Chem 91 2739 1987.] [Beilstein 19 IV 6287, 19/12 V 801.]
Regulatory Status
Included in the FDA Inactive Ingredients Database: α-cyclodextrin
(injection preparations); β-cyclodextrin (oral tablets, topical gels);
γ-cyclodextrin (IV injections).
Included in the Canadian List of Acceptable Non-medicinal
Ingredients (stabilizing agent; solubilizing agent ); and in oral and
rectal pharmaceutical formulations licensed in Europe, Japan, and
the USA.
β-Cyclodextrin Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| HRV Global Life Sciences | +91-9820219686 +91-9820219686 | Telangana, India | 379 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| S D Fine Chem Limited | +91-9323715856 +91-9323715856 | Maharashtra, India | 368 | 58 | Inquiry |
| Gangwal Healthcare Pvt Ltd | +91-9320779960 | Maharashtra, India | 51 | 58 | Inquiry |
| Shreeji Pharma International | 09824326039 | Vadodara, India | 166 | 58 | Inquiry |
| K. Kumar & Co. | 91-33-22354571 | Kolkata, India | 54 | 58 | Inquiry |
| HRV Global Life Sciences Private Limited | 91-40-23554991 | Hyderabad, India | 190 | 58 | Inquiry |
| Anand Agencies | 91-20-24454597 | Maharashtra, India | 2337 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| HRV Global Life Sciences | 58 |
| Ralington Pharma | 58 |
| S D Fine Chem Limited | 58 |
| Gangwal Healthcare Pvt Ltd | 58 |
| Shreeji Pharma International | 58 |
| K. Kumar & Co. | 58 |
| HRV Global Life Sciences Private Limited | 58 |
| Anand Agencies | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
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