Chinese english Japanese Germany Korea
ChemicalBook > Product Catalog >Biochemical Engineering >Saccharides >Polysaccharide >Chitosan

Chitosan

Chitosan Structure
CAS No.
9012-76-4
Chemical Name:
Chitosan
Synonyms
Chitosan oligosaccharides;Flocculant;Chitosane;poliglusam;CARBOXYLATION;Oligochitosan;seacureplus;DEACETYLATED CHITIN;Amino-oligosaccharin;CHITOSANNANOPARTICLES
CBNumber:
CB1479274
Molecular Formula:
C6H11NO4X2
Molecular Weight:
161.16
MOL File:
9012-76-4.mol
MSDS File:
SDS
Modify Date:
2024/8/15 16:24:08
Request For Quotation

Chitosan Properties

Melting point 102.5 °C
Density 1 g/cm3
storage temp. 2-8°C
solubility dilute aqueous acid (pH <6.5).: soluble
form (Coarse ground flakes and powder)
color White to Off-white
Odor Odorless
Stability Stable. Incompatible with strong oxidizing agents.
LogP -11.706 (est)
CAS DataBase Reference 9012-76-4
EPA Substance Registry System Chitosan (9012-76-4)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335-H400
Precautionary statements  P261-P280-P271
Hazard Codes  Xn
Risk Statements  20/21/22-36/37/38
Safety Statements  24/25-36-26
WGK Germany  -
RTECS  FM6300000
F  3
TSCA  Yes
HS Code  39139000

Chitosan price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) C3646 Chitosan from shrimp shells, ≥75% (deacetylated) 9012-76-4 10G ₹2950 2022-06-14 Buy
Sigma-Aldrich(India) C3646 Chitosan from shrimp shells, ≥75% (deacetylated) 9012-76-4 25G ₹5400 2022-06-14 Buy
Sigma-Aldrich(India) C3646 Chitosan from shrimp shells, ≥75% (deacetylated) 9012-76-4 100G ₹16480 2022-06-14 Buy
Sigma-Aldrich(India) C3646 Chitosan from shrimp shells, ≥75% (deacetylated) 9012-76-4 500G ₹51786.8 2022-06-14 Buy
Sigma-Aldrich(India) 900342 Chitosan high purity, non-animal derived, average Mw 100?kDa 9012-76-4 2G ₹35062.18 2022-06-14 Buy
Product number Packaging Price Buy
C3646 10G ₹2950 Buy
C3646 25G ₹5400 Buy
C3646 100G ₹16480 Buy
C3646 500G ₹51786.8 Buy
900342 2G ₹35062.18 Buy

Chitosan Chemical Properties,Uses,Production

Chemical Properties

Chitosan occurs as odorless, white or creamy-white powder or flakes. Fiber formation is quite common during precipitation and the chitosan may look ‘cottonlike’.

Chemical Properties

Chitosan is a weak base and is insoluble in water and organic solvent. However, it is soluble in dilute aqueous acidic solution (pH<6.5), which can convert glucosamine units into soluble form R – NH 3 +.

Occurrence

Chitosan comes from the shell of marine crustaceans.

Uses

Forms gels with multivalent anions. Gives clear solutions that dry to strong, clear films.Flocculant, protein precipitation, encapsulating agent and aqueous thickener.
Chitosan is a natural polycationic linear polysaccharide derived from chitin. The low solubility of chitosan in neutral and alkaline solution limits its application.
Chitosan: An Update on Potential Biomedical and Pharmaceutical Applications

Production Methods

Chitosan is manufactured commercially by chemically treating the shells of crustaceans such as shrimps and crabs. The basic manufacturing process involves the removal of proteins by treatment with alkali and of minerals such as calcium carbonate and calcium phosphate by treatment with acid. Before these treatments, the shells are ground to make them more accessible. The shells are initially deproteinized by treatment with an aqueous sodium hydroxide 3–5% solution. The resulting product is neutralized and calcium is removed by treatment with an aqueous hydrochloric acid 3–5% solution at room temperature to precipitate chitin. The chitin is dried so that it can be stored as a stable intermediate for deacetylation to chitosan at a later stage. NDeacetylation of chitin is achieved by treatment with an aqueous sodium hydroxide 40–45% solution at elevated temperature (1108℃), and the precipitate is washed with water. The crude sample is dissolved in acetic acid 2% and the insoluble material is removed. The resulting clear supernatant solution is neutralized with aqueous sodium hydroxide solution to give a purified white precipitate of chitosan. The product can then be further purified and ground to a fine uniform powder or granules. The animals from which chitosan is derived must fulfil the requirements for the health of animals suitable for human consumption to the satisfaction of the competent authority. The method of production must consider inactivation or removal of any contamination by viruses or other infectious agents.

benefits

Chitosan is a fibrous substance that might reduce how much fat and cholesterol the body absorbs from foods. It also helps blood clot when applied to wounds.

General Description

Chitosan is a linear amino polysaccharide composed of approximately 20% β1,4-linked N-acetyl-D-glucosamine (GlcNAc) and approximately 80% β1,4-linked D-glucosamine (GlcN) that is prepared by the partial deacetylation of chitin in hot alkali.

Pharmaceutical Applications

Chitosan is used in cosmetics and is under investigation for use in a number of pharmaceutical formulations. The suitability and performance of chitosan as a component of pharmaceutical formulations for drug delivery applications has been investigated in numerous studies. These include controlled drug delivery applications, use as a component of mucoadhesive dosage forms, rapid release dosage forms, improved peptide delivery, colonic drug delivery systems, and use for gene delivery. Chitosan has been processed into several pharmaceutical forms including gels, films, beads, microspheres, tablets, and coatings for liposomes. Furthermore, chitosan may be processed into drug delivery systems using several techniques including spray-drying, coacervation, direct compression, and conventional granulation processes.

Safety

Chitosan is being investigated widely for use as an excipient in oral and other pharmaceutical formulations. It is also used in cosmetics. Chitosan is generally regarded as a nontoxic and nonirritant material. It is biocompatible with both healthy and infected skin. Chitosan has been shown to be biodegradable.
LD50 (mouse, oral): >16 g/kg

storage

Chitosan powder is a stable material at room temperature, although it is hygroscopic after drying. Chitosan should be stored in a tightly closed container in a cool, dry place. The PhEur 6.5 specifies that chitosan should be stored at a temperature of 2–88℃.

Incompatibilities

Chitosan is incompatible with strong oxidizing agents.

Regulatory Status

Chitosan is registered as a food supplement in some countries.

Chitosan Preparation Products And Raw materials

Raw materials

Amino tris(methylene phosphonic acid) Acrylamide Formaldehyde Polyacrylamide Sodium hydroxide
Chitin
chevron_left

1of2

chevron_right

Preparation Products

materials of oral delivery system for peptide drugs and their controlled release the gum from the chitin CARBOXYLATION CHITOSAN drug delivery of chitosan carboxymethylcellulose complexes Chitin

Chitosan Suppliers

Global( 848)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ADVENT CHEMBIO PRIVATE LIMITED +91-9821524116 +91-9821524116 Mumbai, India 353 58 Inquiry
Meck Pharmaceuticals and Chemicals Pvt. Ltd. +91-9898053709 +91-9898540709 Gujarat, India 44 58 Inquiry
Karandikars Orgochem Private Limited +91-2220874398 +91-9987688852 Madhya Pradesh, India 5 58 Inquiry
Panvo Organics Pvt Ltd +91 9789806833 +91 9444351711 Tamil Nadu, India 23 58 Inquiry
Nitta Gelatin India Limited +91-9946663101 +91-7736302333 Kerela, India 3 58 Inquiry
Meron Marine Hydrocolloids +91-8086377799 +91-9895767366 Kerela, India 12 58 Inquiry
Suvidhinath Laboratories +918037301617 Gujarat, India 74 58 Inquiry
Intelligent Materials Private Limited 08048953178 Punjab, India 197 58 Inquiry
Longshore Technology 08069033822Ext 901 Maharashtra, India 1 58 Inquiry
Nitta Gelatin India Limited 0484 2864400 New Delhi, India 3 58 Inquiry
Supplier Advantage
ADVENT CHEMBIO PRIVATE LIMITED 58
Meck Pharmaceuticals and Chemicals Pvt. Ltd. 58
Karandikars Orgochem Private Limited 58
Panvo Organics Pvt Ltd 58
Nitta Gelatin India Limited 58
Meron Marine Hydrocolloids 58
Suvidhinath Laboratories 58
Intelligent Materials Private Limited 58
Longshore Technology 58
Nitta Gelatin India Limited 58

Related articles

  • Efficacy of Chitosan
  • Chitin ( N-acetyl-d-glucosamine) is a structural component of crustacean, fungi, insect, annelid, mollusk, and coelenterata ex....
  • Mar 9，2022

Chitosan Spectrum

Chitosan(9012-76-4)IR

9012-76-4(Chitosan)Related Search:

D-Glucose monohydrate Calcium gluconate SEPHADEX G-10 Glucosamine β-1,3-Glucan
Carboxymethyl chitosan Dextran Sulfate Sodium Salt Glycine SEPHADEX G-50 Gluconic acid
Dextran blue 2000 YEAST BETA-GLUCAN D-Glucosamine hydrochloride ALTRENOGEST Dextran
Chitin Xanthan gum CHITOSAN GLYCOL TRIMETHYL AMMONIUM IODIDE
chevron_left

1of4

chevron_right
kimitsuchitosanm kytexh Chitosan, molecular weight: 100,000-300,000 (Poly-N-acetyl--D-glucosamine)-protein 2-amino-2-deoxy-(1→4)-β-d-glucopyranan CHITOSAN,POWDER CHITOSAN,POWDER(BULK methyl N-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-5-[(2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6S)-5-amino-6-[(2R,3S,4R,5R,6R)-5-amino-4,6-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-4-hydroxy-6-(hydroxymethyl)oxan-3-yl]carbamate CHITOSAN(RG) BC 10 (polysaccharide) CTA 1 Lactic Acid Daichitosan VL N-Deacetylchitin Sea Cure 440 WOT Recovery Floc T Chitosan, MW. 100,000-300,000 Chitosan,molecular weight: 600,000-800,000 Chitosan (5-20mPa.s, 0.5% in 0.5% Acetic Acid at 20deg C) Chitosan (50-100mPa.s, 0.5% in 0.5% Acetic Acid at 20deg C) Chitosan (200-500mPa.s, 0.5% in 0.5% Acetic Acid at 20deg C) Poly-(1,4-β-D-glucopyranosamine) Poly-(1→4)-β-D-glucosamine Poly[beta-(1,4)-2-amino-2-deoxy-D-glucose], Poly[beta-(1,4)-D-glucosamine] Chitosan (500 mg) Chitosan, Molecular weight: 100,000-300,000 100GR Chitosan, Molecular weight: 100,000-300,000 50GR Chitosan (Coarse ground flakes and powder) Chitosan froM shriMp shells, practical grade Chitosan high purity, Mv 110,000-150,000 Chitosan high purity, Mv 60,000-120,000 Chitosan,Deacetylated chitin, Poly(D-glucosamine) Chitosan from shrimp shells kytexm seacuref LOWMOLECULARWEIGHTCHITOSAN HIGHMOLECULARWEIGHTCHITOSAN POLY-DELTA-GLUCOSAMINE CHINESETHOROWAXROOTP.E. CHITOSAN, QUICK DISSOLVE CHITOSAN (DEACETYLATED CHITIN) Poly-d-hlocozoamine, yactnyno N-acetylirobann (TY 6-01-1-458-93 CHITOSAN - 100 MESH - BULK DENSITY >0.25 CHITOSAN - 100 MESH - BULK DENSITY >0.5 CHITOSAN - 140 MESH - BULK DENSITY >0.25 CHITOSAN - 140 MESH - BULK DENSITY >0.5 CHITOSAN - 40 MESH - BULK DENSITY >0.25 CHITOSAN - 40 MESH - BULK DENSITY >0.5 CHITOSAN ( FLONAC C ) CHITOSAN ( FLONAC H ) CHITOSAN ( FLONAC N ) CHITOSAN ( FS1) CHITOSAN FC-80 CHITOSAN FCHD-80 CHITOSAN FCMD-100 CHITOSAN FOOD GRADE 100 MESH DAC>90% BULK DENSITY CHITOSAN FOOD GRADE 140 MESH DAC>90% BULK DENSITY CHITOSAN FOOD GRADE 40 MESH DAC>90% BULK DENSITY > Chitosan from crab shells, Deacetylated chitin, Poly(D-glucosamine)