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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Epigenetics >Sirtuin Inhibitors >2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Structure
CAS No.
304896-28-4
Chemical Name:
2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide
Synonyms
AGK2;CS-2248;SIRT,AGK2;AGK2;AGK-2;AGK 2;SIRT2 Inhibitor, AGK2;SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem;2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-(5-quinolyl)acrylamide;2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide;2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide;2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-
CBNumber:
CB42101251
Molecular Formula:
C23H13Cl2N3O2
Molecular Weight:
434.27
MOL File:
304896-28-4.mol
MSDS File:
SDS
Modify Date:
2023/9/4 16:42:00
Request For Quotation

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Properties

Boiling point 675.1±55.0 °C(Predicted)
Density 1.445±0.06 g/cm3(Predicted)
storage temp. room temp
solubility DMSO: soluble2mg/mL, clear (warmed)
form Yellow solid
pka 8.87±0.43(Predicted)
color White to Yellow to Orange

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319
Precautionary statements  P501-P261-P270-P271-P264-P280-P337+P313-P305+P351+P338-P362+P364-P332+P313-P301+P312+P330-P302+P352+P312-P304+P340+P312
Hazard Codes  Xi
Risk Statements  36
Safety Statements  26
WGK Germany  3
HS Code  2934.99.4400
NFPA 704
0
3 0

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide price More Price(6)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) A8231 AGK2 ≥97% (HPLC), powder 304896-28-4 5MG ₹13964.25 2022-06-14 Buy
Sigma-Aldrich(India) A8231 AGK2 ≥97% (HPLC), powder 304896-28-4 25MG ₹55185.85 2022-06-14 Buy
Sigma-Aldrich(India) 566324 SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem The SIRT2 Inhibitor, AGK2, also referenced under CAS 304896-28-4, controls the biological activity of SIRT2. This small molecule/inhibitor is primaril 304896-28-4 5MG ₹13100 2022-06-14 Buy
TCI Chemicals (India) A3193 AGK-2 304896-28-4 5MG ₹3500 2022-05-26 Buy
TCI Chemicals (India) A3193 AGK-2 304896-28-4 25MG ₹9200 2022-05-26 Buy
Product number Packaging Price Buy
A8231 5MG ₹13964.25 Buy
A8231 25MG ₹55185.85 Buy
566324 5MG ₹13100 Buy
A3193 5MG ₹3500 Buy
A3193 25MG ₹9200 Buy

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Chemical Properties,Uses,Production

Uses

AGK2 is a SIRT2 inhibitor. AGK2 has been used in a study to determine that SIRT2 inhibition induces cell death and decreases the intracellular ATP level. AGK2 also rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models.

Biological Activity

Selective inhibitor of SIRT2 (IC 50 = 3.5 μ M). Displays no activity at SIRT1 and SIRT3 at concentrations up to 40 μ M. Reduces α -synuclein-mediated toxicity in in vitro and in vivo models of Parkinson's disease.

Biochem/physiol Actions

AGK2 is a SIRT2 inhibitor. AGK2 rescues dopamine neurons from α-synuclein toxicity in Parkinson′s disease models. IC50 for SIRT2 = 3.5 uM. AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. AGK2 may be the most selective SIRT2 inhibitor available.

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Preparation Products And Raw materials

Raw materials

Preparation Products

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Suppliers

Global( 112)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
TCI Chemicals (India) Pvt. Ltd. 1800 425 7889 New Delhi, India 6778 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29826 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd +86-86-22-87899925 +86-8618522618860 China 694 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
Nantong HI-FUTURE Biology Co., Ltd. +undefined18051384581 China 3136 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Supplier Advantage
A.J Chemicals 58
TCI Chemicals (India) Pvt. Ltd. 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd 58
Dideu Industries Group Limited 58
InvivoChem 58
Nantong HI-FUTURE Biology Co., Ltd. 58
TargetMol Chemicals Inc. 58

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide Spectrum

2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide(304896-28-4)1HNMR

304896-28-4(2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide)Related Search:

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2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide AGK2 SIRT2 Inhibitor, AGK2 2-Cyano-3-(5-(2,5-dichlorophenyl)furan-2-yl)-N-(quinolin-5-yl)acrylamide SIRT2 Inhibitor, AGK2 - CAS 304896-28-4 - Calbiochem CS-2248 AGK2;AGK-2;AGK 2 2-Propenamide, 2-cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl- 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-5-quinolinyl-2-propenamide USP/EP/BP SIRT,AGK2 2-Cyano-3-[5-(2,5-dichlorophenyl)-2-furanyl]-N-(5-quinolyl)acrylamide 304896-28-4 C23H13Cl2N3O2AgK2 C23H13Cl2N3O2 Inhibitors