ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Aromatic ketones >2,4'-Dibromoacetophenone

2,4'-Dibromoacetophenone

2,4'-Dibromoacetophenone Structure
CAS No.
99-73-0
Chemical Name:
2,4'-Dibromoacetophenone
Synonyms
99-73-0;2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE;PBPB;2-BROMO-1-(4-BROMOPHENYL)ETHANONE;P-BROMOPHENACYL BROMIDE;4-BROMOPHENACYL BROMIDE;p-bromophenacyl-8;AKOS BBS-00000865;GSK-3β Inhibitor VII;BromophenacylBromide
CBNumber:
CB4239093
Molecular Formula:
C8H6Br2O
Molecular Weight:
277.94
MOL File:
99-73-0.mol
MSDS File:
SDS
Modify Date:
2023/8/31 16:33:09

2,4'-Dibromoacetophenone Properties

Melting point 108-110 °C(lit.)
Boiling point 1415°C/760mm
Density 1.7855 (rough estimate)
refractive index 1.5560 (estimate)
storage temp. Store below +30°C.
solubility DMF: 5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml; PBS (pH 7.2): insol
form Crystalline Solid
color Slightly yellow to beige
Water Solubility Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water.
Sensitive Lachrymatory
Merck 14,1427
BRN 607604
Stability Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents.
InChIKey FKJSFKCZZIXQIP-UHFFFAOYSA-N
CAS DataBase Reference 99-73-0(CAS DataBase Reference)
EPA Substance Registry System Ethanone, 2-bromo-1-(4-bromophenyl)- (99-73-0)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05
Signal word  Danger
Hazard statements  H314
Precautionary statements  P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363
Hazard Codes  C
Risk Statements  34
Safety Statements  26-36/37/39-45
RIDADR  UN 3261 8/PG 2
WGK Germany  2
RTECS  AM6950000
19-21
Hazard Note  Corrosive/Lachrymatory
TSCA  T
HazardClass  8
PackingGroup  III
HS Code  29147090
NFPA 704
0
3 0

2,4'-Dibromoacetophenone price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) D38308 2,4′-Dibromoacetophenone >98% 99-73-0 10G ₹2089.23 2022-06-14 Buy
Sigma-Aldrich(India) D38308 2,4′-Dibromoacetophenone >98% 99-73-0 50G ₹7068.73 2022-06-14 Buy
Sigma-Aldrich(India) D38308 2,4′-Dibromoacetophenone >98% 99-73-0 100G ₹11301.3 2022-06-14 Buy
Sigma-Aldrich(India) 68082 2,4′-Dibromoacetophenone for HPLC derivatization, LiChropur?, ≥99.0% (HPLC) 99-73-0 5G ₹6137.78 2022-06-14 Buy
Sigma-Aldrich(India) 361548 GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem The GSK-3β Inhibitor VII, also referenced under CAS 99-73-0, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily us 99-73-0 5MG ₹17860 2022-06-14 Buy
Product number Packaging Price Buy
D38308 10G ₹2089.23 Buy
D38308 50G ₹7068.73 Buy
D38308 100G ₹11301.3 Buy
68082 5G ₹6137.78 Buy
361548 5MG ₹17860 Buy

2,4'-Dibromoacetophenone Chemical Properties,Uses,Production

Chemical Properties

2,4'-Dibromoacetophenone is off-white crystals or powder

Uses

2,4'-Dibromoacetophenone is used as a reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters, for use in the protection of phenols and carboxylic acids. It undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. It is also useful in the esterification of carboxylic acids.

General Description

A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC50 = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM.

Purification Methods

Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.]

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OMEGA-BROMOACETOPHENONE bromomethyl4-bromophenylketone bromomethylp-bromophenylketone omega,4-dibromoacetophenone p,alpha-dibromoacetophenone p-Dibromoacetophenone 2,4’-dibromo-acetophenon 2-bromo-1-(4-bromophenyl)-ethanon 4,alpha-dibromoacetophenone 4-bromo(bromoacetyl)benzene -4-Dibromoacetophenone 4-BROMOPHENACYL BROMIDE [FOR HPLC LABELING] 4-BROMOPHENACYL BROMIDE (2,4''-DIBROMOACETOPHENONE) 2,4'-Dibromoacetophenone, 98+% PARA-BROMOPHENACYLBROMIDE Acetophenone, 2,4'-dibromo 2,4'-Dibromoacetophenone GSK-3β Inhibitor VII 2,4′-Dibromoacetophenone,4′-Bromophenacyl bromide 2-Bromo-4'-bromoacetophenone 4-Bromophenacyl Bromide 99% Ar a,4-Dibromoacetophenone 4-BROMOPHENACYL BROMIDE, FOR FLUOR-ESCEN CE BromophenacylBromide 4-BromophenacylBromide98% 4-Bromophenacyl Bromide 98% Ethanone, 2-bromo-1-(4-bromophenyl)- à-4-dibromoacetophenone 2,4'-DibroMo-acetophenone > 2,4- twobroMoacetophenone 2,4'-DibroMoacetophenone, 97+% 2,4'-Dibromoacetophenone puriss., >=98.5% (HPLC) ALPHA,4'-DIBROMOACETOPHENONE ALPHA-4-DIBROMOACETOPHENONE ALPHA,P-DIBROMOACETOPHENONE AKOS BBS-00000865 4'-BROMOPHENACYL BROMIDE 4,OMEGA-DIBROMOACETOPHENONE A,P-DIBROMOACETOPHENONE GSK-3BETA INHIBITOR VII DIBROMOACETOPHENONE-2,4 GSK-3β Inhibitor VII - CAS 99-73-0 - Calbiochem Platinum oxide monohydrate (IV) 4-Bromophenacyl Bromide > 4-Bromophenacyl Bromide [for HPLC Labeling]> 2,4'-DIBROMOACETOPHENONE FOR SYNTHESIS 2,4′-dibromoacetophenone 2 P-BROMOPHENACYL BROMIDE PBPB p-bromophenacyl-8 99-73-0 4-BROMOPHENACYL BROMIDE 2-BROMO-1-(4-BROMOPHENYL)ETHANONE 2-BROMO-1-(4-BROMOPHENYL)ETHAN-1-ONE ω.ρ-Dibromoacetoplenone 2,4'-Dibromoacetophenone 99-73-0 BrCH2COC6H4Br