PSYCHOSINE
![PSYCHOSINE Structure](CAS/GIF/2238-90-6.gif)
- CAS No.
- 2238-90-6
- Chemical Name:
- PSYCHOSINE
- Synonyms
- PSYCHOSIN;PSYCHOSINE;PSYCHOSINE(RG);LYSO-CEREBROSIDE;PSYCHOSINE USP/EP/BP;Galactosylsphingosine;O-Galactosylsphingosine;Psychosine (free amine);Sphingosine galactoside;LYSO-CERAMIDEGALACTOSIDE
- CBNumber:
- CB4245038
- Molecular Formula:
- C24H47NO7
- Molecular Weight:
- 461.63
- MOL File:
- 2238-90-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:08
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS02,GHS06,GHS08 |
|||||||||
---|---|---|---|---|---|---|---|---|---|---|
Signal word | Danger | |||||||||
Hazard statements | H225-H301+H311+H331-H370 | |||||||||
Precautionary statements | P210-P260-P280-P301+P310+P330-P308+P311-P370+P378-P403+P233 | |||||||||
Hazard Codes | Xn | |||||||||
Risk Statements | 20/21/22 | |||||||||
Safety Statements | 36 | |||||||||
WGK Germany | 3 | |||||||||
NFPA 704 |
|
PSYCHOSINE price More Price(2)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | P9256 | Psychosine from bovine brain lyophilized powder, ≥98% (TLC) | 2238-90-6 | 1MG | ₹8486.8 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | P9256 | Psychosine from bovine brain lyophilized powder, ≥98% (TLC) | 2238-90-6 | 10MG | ₹45789.75 | 2022-06-14 | Buy |
PSYCHOSINE Chemical Properties,Uses,Production
Description
Galactosylsphingosine is a bioactive sphingolipid. It potentiates LPS-induced production of inflammatory cytokines, decreases the mitochondrial membrane potential, and induces cell death in mouse astrocytes, effects that can be reversed by the sphingosine-1-phosphate receptor agonist FTY720 phosphate . Galactosylsphingosine (0.1 and 1 μM) induces demyelination of mouse cerebellar slices. It inhibits PDGF-induced translocation of PKC to the cell surface and induces apoptosis in MO3.13 oligodendrocytes. Galactosylsphingosine (10 and 15 μM) inhibits gene transcription mediated by peroxisome proliferator-activated receptor α (PPARα) in reporter assays using C6 glial cells. Levels of galactosylsphingosine are increased in postmortem brain from patients with Krabbe disease, a lysosomal storage disorder characterized by a β-galactosylceramidase deficiency.[Matreya, LLC. Catalog No. 1305]
Uses
Psychosine is a cationic lysosphingolipid that displays neuroprotective effects against quisqualate.
Definition
ChEBI: A glycosylsphingoid consisting of sphingosine having a beta-D-galactosyl residue attached at the 1-position.
General Description
Galactosyl(β) Sphingosine (d18:1) is a substrate for the enzyme endoglycoceramidase I (EGCase I). It has sphingosine backbone with galactose attached to it and is a brain glycospingolipid.
Enzyme inhibitor
This cationic brain lysosphingolipid (FWfree-base = 461.64 g/mol; CAS 2238- 90-6), also known as 1-O-b-D-galactosylsphingosine, inhibits metabotropic a1-adrenergic receptor signaling-induced phospholipase C activation in rat brain astrocytes. Psychosine also exerts protective effects against quisqualate, suggesting it may be useful in prophylaxis of neurodegenerative disorders arising from over-stimulation of hippocampal Group 1 metabolotropic glutamate receptor, or mGluR. Psychosine is the product of the reaction catalyzed by sphingosine b-galactosyltransferase and is the substrate for psychosine sulfotransferase and galactosylceramidase. Target(s): cerebroside-sulfatase, or arylsulfatase A; cytochrome c oxidase; cytokinesis; electron transport; galactosylgalactosylglucosylceramidase; glucocerebrosidase, lysosome; b-glucosidase; phosphorylase kinase; protein kinase C (11- 14); protein-tyrosine sulfotransferase; and sphingomyelinase.
PSYCHOSINE Preparation Products And Raw materials
Raw materials
Preparation Products
PSYCHOSINE Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26216 | 58 | Inquiry |
Alfa Chemistry | +1-5166625404 | United States | 21317 | 58 | Inquiry |
LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
LGC Standards | +44 (0)20 8943 8480 | United Kingdom | 6495 | 0 | Inquiry |
United States Biological | 800.520.3011 or 781.639.5092 | United States | 6256 | 80 | Inquiry |
Yichang Zhongyitai Trading Co., Ltd. | 0717-6449896 13886658719 | China | 1977 | 58 | Inquiry |
Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | China | 4428 | 55 | Inquiry |
Supplier | Advantage |
---|---|
BOC Sciences | 58 |
TargetMol Chemicals Inc. | 58 |
Dideu Industries Group Limited | 58 |
Alfa Chemistry | 58 |
LEAPCHEM CO., LTD. | 58 |
Aladdin Scientific | 58 |
LGC Standards | 0 |
United States Biological | 80 |
Yichang Zhongyitai Trading Co., Ltd. | 58 |
Guangzhou Isun Pharmaceutical Co., Ltd | 55 |
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