N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
![N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Structure](CAS/GIF/329196-48-7.gif)
- CAS No.
- 329196-48-7
- Chemical Name:
- N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide
- Synonyms
- SANT-2;Hh Signaling Antagonist XIV, SANT-2;Hh Signaling Antagonist XIV, SANT-2 - CAS 329196-48-7 - Calbiochem;N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide;N-(3-(1H-Benzo[d]imidazol-2-yl)-4-chlorophenyl)-3,4,5-triethoxybenzamide;Benzamide, N-[3-(1H-benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxy-
- CBNumber:
- CB42518880
- Molecular Formula:
- C26H26ClN3O4
- Molecular Weight:
- 479.96
- MOL File:
- 329196-48-7.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/18 11:31:17
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide price More Price(2)
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Chemical Properties,Uses,Production
Uses
SANT-2 is an inhibitor of Smo (Hedgehog signaling pathway) and SAG.
General Description
A nanomolar Smoothened (smo) antagonist that exhibits 2.3- and 6-fold weaker biological activity than SANT-1 (Cat. No. 559303), respectively, in antagonizing ShhNp- and SAG-stimulated hedgehog pathway activation in HEK 293-based (Shh-LIGHT2) reporter assays. Competitive binding studies show full replacement of Smo-bound cyclopamine (Cat. No. 239803) by SANT-1 and SANT-2 (Ki = 2.4 and 8.4 nM, respectively), while SANT-1 and SANT-2 are shown to compete against Smo-bound SAG-1.3 (Cat. Nos. 566660 & 566661) in an allosteric manner and that only SANT-2, but not SANT-1, is able to completely compete off bound SAG-1.3 (100% vs. 40% replacement by the respective compound at 10 μM).
Biochem/physiol Actions
SANT-2 is a potent sonic hedgehog pathway (shh) antagonist that directly inhibits by binding to the smoothened receptor.
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Preparation Products And Raw materials
Raw materials
Preparation Products
N-[3-(1H-Benzimidazol-2-yl)-4-chlorophenyl]-3,4,5-triethoxybenzamide Suppliers
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| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
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| Cayman Chemical Company | (800) 364-9897 | United States | 6618 | 81 | Inquiry |
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| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | China | 4966 | 55 | Inquiry |
| BOC Sciences | USA | 0 | 65 | Inquiry | |
| Yantai Lianhua Technology Co., Ltd | 15552437730 | China | 10831 | 58 | Inquiry |