JERVINE
- CAS No.
- 469-59-0
- Chemical Name:
- JERVINE
- Synonyms
- Iervin;jerwiny;JERVINE;23ßJervine>Jervin-11-one;Jervine (8CI);Jervine ((3ß11-KETOCYCLOPAMINE;DL-ISOLEUCINE GRADE II
- CBNumber:
- CB7326145
- Molecular Formula:
- C27H39NO3
- Molecular Weight:
- 425.6
- MOL File:
- 469-59-0.mol
- Modify Date:
- 2024/1/5 22:10:32
| Melting point | 242- 244°C |
|---|---|
| alpha | D20 -150° (ethanol) (Saito); D20 -167.6° (chloroform) (Poethke) |
| Boiling point | 541.31°C (rough estimate) |
| Density | 1.18±0.1 g/cm3 (20 ºC 760 Torr) |
| refractive index | 1.6400 (estimate) |
| storage temp. | −20°C |
| solubility | methanol: >2 mg/mL |
| form | solid |
| pka | 14.98±0.70(Predicted) |
| color | White |
| λmax | 250nm(lit.) |
| Merck | 14,5264 |
| Stability | Store in Freezer at - 20°C |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H360D | |||||||||
| Precautionary statements | P201-P301+P310+P330 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| RIDADR | UN 2811 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | WG9700000 | |||||||||
| HazardClass | 6.1 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29349990 | |||||||||
| Toxicity | LD50 i.v. in mice: 9.3 mg/kg (Krayer); LD50 s.c. in male mice: 29 mg/kg (Tanaka) | |||||||||
| NFPA 704 |
|
JERVINE price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | J4145 | Jervine ≥98% (HPLC), powder | 469-59-0 | 1MG | ₹18272.6 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 420210 | Jervine - CAS 469-59-0 - Calbiochem A cell-permeable steroidal alkaloid similar to cyclopamine that displays teratogenic effects and induces cyclopia by blocking Sonic Hedgehog signaling | 469-59-0 | 1MG | ₹15469.99 | 2022-06-14 | Buy |
| TCI Chemicals (India) | J0009 | Jervine | 469-59-0 | 10MG | ₹9900 | 2022-05-26 | Buy |
JERVINE Chemical Properties,Uses,Production
Description
First obtained from Veratrum grandiflorum by Wright and Luff, this alkaloid is
also present in V. album. It was originally given the formula C26H3703N. 2H20,
subsequently altered to that given above by Jacobs and Craig. The base crystallizes from aqueous EtOH in stellate groups of colourless prisms and has [α]D -
147° (EtOH). The hydrochloride (dihydrate) has m.p. 208°C (Wright and Luff)
or 330-334°C (dec.) according to Jacobs and Craig, the latter finding a change
in crystalline form at 280°C. The hydriodide has m.p. 302-5°C; the nitrate and
aurichloride are both crystalline and the picrate melts at 278-284°C. TheN-nitroso derivative has m.p. 246-7°C; the N-acety1 compound, m.p. 161-2°C
and the O,N-diacetyl derivative, m.p. 17 6-7°C.
Treatment with aluminium tert-butoxide gives Δ4-jervone, m.p. 193-4°C;
[α]28D + 28.3° (EtOH), giving an oxime, m.p. 287-9°C and reduced by aluminium isopropoxide to Δ4-jervine, m.p. 203- 2 11°C. Catalytic hydrogenation
with Pd-C yields the dihydro derivative, m.p. 248-251°C; [α]26D - 82° (EtOH).
On further hydrogenation, the tetrahydro compound is formed, m.p. 216-
221°C; [α]28D - 18° (EtOH). Jervine may be reduced by sodium in butanol to
a:-dihydrojervinol, m.p. 223-5°C; [α]27D - 107° (EtOH). The similar reduction
of dihydrojervine yields (3-dihydrojervino1, m.p. 286-9°C; [α]28D-4 C(EtOH). On
Se dehydrogenation, the alkaloid behaves like cevine (q.v.) giving a mixture of
bases and hydrocarbons from which the following have been isolated; 5-methyl-
2-ethylpyridine; 5-methyl-2-ethyl-3-hydroxypyridine; C2oH22 , m.p. 79°C;
C24H30, m.p. 100- 1°C; C2l H24 , m.p. 70-8 1°C; C2oH 16 , m.p. I 25-7°C and
C22H20 , m.p. I 54-5℃。
In large doses, the alkaloid produces vasodilatation and a fall in blood
pressure
Chemical Properties
White Crystalline Solid
Uses
Has antibacterial properties. Jervine demonstrates teratogenic properties. It is the starting material for C-nor-D-homosteroids. Jervine induces holoprosencephaly and blocks endogenous Sonic hedgehog signaling
Purification Methods
4 Crystallise Jervine from MeOH/H2O or Me2O. The hydrochloride has m 300-302o (from MeOH/Et2O), and the picrate has m 26
References
Wright, Luff., J. Chern. Soc., 35,405 (1879)
Saltzberger., Arch. Pharrn., 228,462 (1890)
Bredemann., Apoth. Zeit., 21,41,53 (1906)
Saito, Suginome, Takaoka., Bull. Chern. Soc. Japan, 9, 15(1934)
Saito, Suginome, Takaoka., ibid, 11, 168, 172 (I936)
Poethke., Arch. Pharrn., 357,571 (I937)
Poethke., ibid, 276, 170 (1938)
Jacobs, Craig., J. BioI. Chern., 148, 51 (1943)
Seiferle.,J. Econ. Entorn., 35,35 (1942)
Jacobs et al., J. Bioi. Chern., 170, 635 (1947)
Wintersteiner et al., J. A mer. Chern. Soc., 73, 2970 (1951)
Wintersteiner, Hosansky., ibid, 74,4474 (1952)
Stereochemistry:
Kupchan, Suffness., J. A mer. Chern. Soc., 90, 2730 (1968)
Masamune et al., Tetrahedron, 24, 3461 (1968)
JERVINE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29901 | 58 | Inquiry |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | CHINA | 1824 | 58 | Inquiry |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 | China | 3424 | 58 | Inquiry |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 | China | 3000 | 58 | Inquiry |
| BOC Sciences | +1-631-485-4226 | United States | 19553 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | China | 12210 | 58 | Inquiry |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | China | 10326 | 58 | Inquiry |