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CC0651

CC0651 Structure
CAS No.
1319207-44-7
Chemical Name:
CC0651
Synonyms
CC0651;CC0651,CC-0651;(2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid;4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid;L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-
CBNumber:
CB42627678
Molecular Formula:
C20H21Cl2NO6
Molecular Weight:
442.29
MOL File:
1319207-44-7.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:08
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CC0651 Properties

Boiling point 755.7±60.0 °C(Predicted)
Density 1.410±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥ 56 mg/mL (126.61 mM)
pka 3.37±0.34(Predicted)
form Powder
color White to off-white

CC0651 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 5.09704 Cdc34 Inhibitor, CC0651 - CAS 1319207-44-7 - Calbiochem A cell-permeable, selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC?? = 2.5 μM in a Sic1-SCFCdc4 assay). 1319207-44-7 10MG ₹24040 2022-06-14 Buy
Product number Packaging Price Buy
5.09704 10MG ₹24040 Buy

CC0651 Chemical Properties,Uses,Production

General Description

A cell-permeable biphenylylpentanoic acid compound that acts as a selective allosteric inhibitor of E2 ubiquitin-conjugating enzyme Cdc34 (IC50 = 2.5 μM in a Sic1-SCFCdc4 assay) without affecting the activities of E1 or E3 ligases. Reported to act by trapping a weak interaction between ubiquitin and the E2 donor ubiquitin-binding site and may serve as a molecular bridge between Cdc34A and ubiquitin. Binds to Cdc34ACAT alone with an EC50 value of 267 μM, but in the presence of ubiquitin, this affinity is significantly increased (EC50 = 19 μM). Does not disrupt the interaction of Cdc34A with the RING domain of Rbx1 and is suggested to even moderately stabilize this interaction. Shown to inhibit p27Kip1 ubiquitination (IC50 = 1.72 μM) and reduce PC-3 cancer cells proliferation (~30 μM).

Please note that the molecular weight for this compound is batch-specific due to variable water content.

Biochem/physiol Actions

Cell permeable: yes

CC0651 Preparation Products And Raw materials

Raw materials

Preparation Products

CC0651 Suppliers

Global( 36)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd +8618327326525 China 8474 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
RD International Technology Co., Limited 18024082417 China 9268 58 Inquiry
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581 China 4659 58 Inquiry
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 021-59167510 18117107507 China 5012 58 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5729 77 Inquiry
United States Biological 1-800-520-3011 United States 6106 58 Inquiry
Shanghai Weiwei Biological Technology Co., Ltd. 021-55669583 18616258598 CHINA 4398 58 Inquiry
Shanghai Yuda Industrial Co., Ltd. 021-64133189 13788995069 CHINA 6107 58 Inquiry
Supplier Advantage
TargetMol Chemicals Inc. 58
Wuhan Topule Biopharmaceutical Co., Ltd 58
Aladdin Scientific 58
RD International Technology Co., Limited 58
Nantong QuanYi Biotechnology Co., Ltd 58
Shanghai?Medlife?Pharm-Tech?Co.,?Ltd 58
Tocris Bioscience 77
United States Biological 58
Shanghai Weiwei Biological Technology Co., Ltd. 58
Shanghai Yuda Industrial Co., Ltd. 58

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L-Arabinonic acid, 4,5-dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]- CC0651 4,5-Dideoxy-5-(3',5'-dichloro[1,1'-biphenyl]-4-yl)-4-[(2-methoxyacetyl)amino]-L-arabinonic acid (2R,3S,4S)-5-[4-(3,5-Dichlorophenyl)phenyl]-2,3-dihydroxy-4-(2-methoxyacetamido)pentanoic acid CC0651,CC-0651 1319207-44-7 C20H21Cl2NO6