ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >GDC-0077

GDC-0077

CAS No.: 2060571-02-8

Chemical Name:: GDC-0077

Synonyms: CPD1573;RG 6114;GDC-0077;RO 7113755;Inavolisib;GDC-0077 Inavolisib;Inavolisib (GDC-0077);GDC-0077; RG 6114; RO 7113755;Inavolisib (Synonyms: GDC-0077;Apoptosis,RG 6114,RG-6114,Phosphoinositide 3-kinase,Inhibitor,PI3K,Inavolisib,GDC 0077,GDC0077,inhibit

CBNumber:: CB43175543

Molecular Formula:: C18H19F2N5O4

Molecular Weight:: 407.37

MOL File:: 2060571-02-8.mol

Modify Date:: 2024/4/24 9:22:13

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GDC-0077 Properties

Boiling point	698.0±65.0 °C(Predicted)
Density	1.63±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
solubility	DMSO:110.0(Max Conc. mg/mL);245.47(Max Conc. mM)
pka	15.89±0.50(Predicted)
form	Solid
color	Off-white to yellow
InChIKey	SGEUNORSOZVTOL-CABZTGNLSA-N
SMILES	C(N)(=O)[C@@H](NC1C=C2OCCN3C=C(N4[C@H](C(F)F)COC4=O)N=C3C2=CC=1)C

GDC-0077 Chemical Properties,Uses,Production

Description

Inavolisib, or GDC-0077, is a potent and selective PI3K inhibitor. GDC-0077 blocks an enzyme involved in cancer growth called PI3K. GDC0077 binds to and inhibits various members of the PI3K family, including activating mutations in the catalytic alpha isoform PIK3CA. PI3K inhibition prevents the activation of the PI3K-mediated signaling pathway and inhibits the growth and survival of PI3K-overexpressing tumor cells. The IUPAC name of this compound is (S)-2-((2-((S)-4-(difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide.

in vitro

GDC-0077 (RG6114) is >300-fold more selective for PI3Kα over the other class I PI3K isoforms (β, δ, and γ) and >2000-fold more selective over PIK family members. GDC-0077 selectively degrades mutant PI3Kα in a proteasome-dependent fashion, resulting in a reduction of PI3K pathway activity biomarkers such as pAKT and pPRAS40, inhibition of cell proliferation, and increased apoptosis in human PIK3CA-mutant breast cancer cell lines to a greater extent when compared to PIK3CA wild-type cells.

GDC-0077 Preparation Products And Raw materials

Raw materials

Preparation Products

GDC-0077 Suppliers

Global( 70)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry
Hubei Chuchang Biotech Co., Ltd.	+undefined15623860702	China	111	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32836	60	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30250	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Suzhou ARTK Medchem Co., Ltd.	+8618168183658	China	39010	58	Inquiry

Supplier	Advantage
Nantong HI-FUTURE Biology Co., Ltd.	58
Hubei Chuchang Biotech Co., Ltd.	58
ATK CHEMICAL COMPANY LIMITED	60
BOC Sciences	58
TargetMol Chemicals Inc.	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
Aladdin Scientific	58
Suzhou ARTK Medchem Co., Ltd.	58

GDC-0077 Spectrum

GDC-0077(2060571-02-8)¹HNMR

2060571-02-8(GDC-0077)Related Search:

2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- GDC-0623 GDC0575 (R)-N-(4-(3-aminopiperidin-1-yl)-5-bromo-1H-pyrrolo[2,3-b]pyridin-3-yl)cyclopropanecarboxamide 2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one XL518 DONEPEZIL HYDROCHLORIDE TDZD-8 4SC-202

CEP-32496 N2-[2-Methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N4-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine PURVALANOL A Testolactone AGI6780

CC0651 6-Amino-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-N-(1-methylethyl)-9H-purine-9-propanamine IDO-IN-7

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GDC-0077 Inavolisib Propanamide, 2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]-, (2S)- (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide GDC-0077; RG 6114; RO 7113755 RO 7113755 RG 6114 CPD1573 Inavolisib (GDC-0077) GDC-0077 Inavolisib Apoptosis,RG 6114,RG-6114,Phosphoinositide 3-kinase,Inhibitor,PI3K,Inavolisib,GDC 0077,GDC0077,inhibit (S)-2-[[2-[(S)-4-(Difluoromethyl)-2-oxo-3-oxazolidinyl]-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl]amino]propanamide Inavolisib (Synonyms: GDC-0077 (S)-2-((2-((S)-4-(Difluoromethyl)-2-oxooxazolidin-3-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)amino)propanamide 2060571-02-8