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ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >PI3K inhibitor >(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Structure
CAS No.
1032754-93-0
Chemical Name:
(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one
Synonyms
CS-4;RG7422;GNE 390;GDC-0980;GDC-0981;Apitolisib;GDC-0980 (RG7422);RG7422 (Apitolisib);Apitolisib(GDC-0980);GDC-0980 (Apitolisib)
CBNumber:
CB32554362
Molecular Formula:
C23H30N8O3S
Molecular Weight:
498.6
MOL File:
1032754-93-0.mol
MSDS File:
SDS
Modify Date:
2023/6/8 9:03:09
Request For Quotation

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Properties

Melting point >202°C (dec.)
Density 1.399
storage temp. -20°C Freezer
solubility Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form Solid
pka 13.90±0.20(Predicted)
color White to Light Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501
NFPA 704
0
2 0

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Chemical Properties,Uses,Production

Uses

GDC-0980 is used in the synthesis of PI3K inhibitors to treat carcinomas. Potent PI3K/mTOR dual Inhibitor.

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Preparation Products And Raw materials

Raw materials

5-(7-Methyl-4-Morpholino-6-(piperazin-1-ylMethyl)thieno[3,2-d]pyriMidin-2-yl)pyriMidin-2-aMine 1-Piperazinecarboxylic acid, 4-[[2-(2-aMino-5-pyriMidinyl)-7-Methyl-4-(4-Morpholinyl)thieno[3,2-d]pyriMidin-6-yl]Methyl]-, 1,1-diMethylethyl ester (S)-1-(4-((2-chloro-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazin-1-yl)-2-hydroxypropan-1-one 1-Piperazinecarboxylic acid, 4-[[2-chloro-7-Methyl-4-(4-Morpholinyl)thieno[3,2-d]pyriMidin-6-yl]Methyl]-, 1,1-diMethylethyl ester 2-Amino-pyrimidine-5-boronic acid
2-Aminopyrimidine-5-boronic Acid Pinacol Ester Thieno[3,2-d]pyriMidine, 2-chloro-7-Methyl-4-(4-Morpholinyl)- 4-(4,4,5,5-TetraMethyl-1,3,2-dioxaborolan-2-yl)pyriMidin-2-aMine 2-chloro-7-Methyl-4-Morpholinothieno[3,2-d]pyriMidine-6-carbaldehyde 1-Propanol
L(+)-Lactic acid
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Preparation Products

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Suppliers

Global( 162)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Pharma Affiliates 172-5066494 Haryana, India 6761 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32760 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29900 58 Inquiry
Chongqing Chemdad Co., Ltd +86-023-6139-8061 +86-86-13650506873 China 39916 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26063 58 Inquiry
Supplier Advantage
A.J Chemicals 58
Pharma Affiliates 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Capot Chemical Co.,Ltd. 60
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
Chongqing Chemdad Co., Ltd 58
CONIER CHEM AND PHARMA LIMITED 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Spectrum

(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one(1032754-93-0)1HNMR

1032754-93-0((S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one)Related Search:

2,6-dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide GDC-0077 XL518 DONEPEZIL HYDROCHLORIDE Angeli’s Salt
Lignosulfonic acid PYRIMITHAMINE Pyrimidine 2,4,6-Triaminopyrimidine 4-Amino-2,6-dimethoxypyrimidine
(S)-tert-butyl 2-(4-(4-chlorophenyl)-2,3,9-triMethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate ADX-47273 XEN445 BKM120 (NVP-BKM120, Buparlisib) MK-2206 2HCl
GDC-0068 Alpelisib (BYL719) Pictilisib
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(S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one GNE 390 GDC-0980 (S)-1-(4-((2-(2-aMinopyriMidin-5-yl)-7-Methyl-4-Morpholinothieno[3,2-d]pyriMidin-6-yl)Methyl)piperazin-1-yl)-2-hydroxypropan-1-one GDC-0980 (RG7422) RG7422 Apitolisib Apitolisib (GDC-0980, RG7422) (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one GNE 390 GDC0980(RG7422) GNE 390 (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one Apitolisib(GDC-0980) RG7422 (Apitolisib) GDC-0981 GDC-0980 (RG7422);GNE 390; GDC 0980; RG 7422 (S)-1-(4-((2-(2-Aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)p (2S)-1-[4-[[2-(2-AMINOPYRIMIDIN-5-YL)-7-METHYL-4-MORPHOLIN-4-YLTHIENO[3,2-D]PYRIMIDIN-6-YL]METHYL]PIPERAZIN-1-YL]-2-HYDROXYPROPAN-1-ONE GDC-0980, 98%, a potent PI3K inhibitor GDC-0980 (Apitolisib, RG7422) GDC 0980 - RG 7422 | GNE 390 | Apitolisib GDC-0980; RG7422; RG-7422; GDC 0980; GNE 390;GDC0980. CS-4 1-Propanone, 1-[4-[[2-(2-amino-5-pyrimidinyl)-7-methyl-4-(4-morpholinyl)thieno[3,2-d]pyrimidin-6-yl]methyl]-1-piperazinyl]-2-hydroxy-, (2S)- (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one USP/EP/BP GDC-0980 (Apitolisib) Apitolisib (GDC-0980, RG-7422, GNE-390) RG 7422|||GNE 390|||GDC-0980 1032754-93-0 C23H30N8O3S Akt mTOR PI3K Inhibitors PI3K/Akt/mTOR An inhibitor of Class I PI3 kinase and mTOR kinase.