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RKI1447

RKI1447 Structure
CAS No.
1342278-01-6
Chemical Name:
RKI1447
Synonyms
RKI-1447;RKI 1447;CS-855;RKI1447;RKI-1447, >=98%;RKI 1447; RKI1447;RKI1447 USP/EP/BP;7-Pentahydroxyflavone;1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA;1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea
CBNumber:
CB42660015
Molecular Formula:
C16H14N4O2S
Molecular Weight:
326.37
MOL File:
1342278-01-6.mol
MSDS File:
SDS
Modify Date:
2023/5/18 11:31:16
Request For Quotation

RKI1447 Properties

Melting point >205oC (dec.)
Density 1.408±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Methanol (Slightly, Heated)
pka 6.36±0.70(Predicted)
form Solid
color Pale Yellow to Pale Beige

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319
Precautionary statements  P305+P351+P338

RKI1447 Chemical Properties,Uses,Production

Description

RKI-1447 is an inhibitor of the Rho-associated kinases ROCK1 and 2 (IC50s = 14.5 and 6.2 nM, respectively) that functions by binding to the ATP binding site of the kinase. In cancer cells, RKI-1447 at a concentration of 100 nM has been found to suppress the activation of ROCK substrates myosin light chain (MLC)-2 and the MLC phosphatase PP1 regulatory subunit MYPT1 without effect on the phosphorylation of Akt, MEK, or S6 kinase. Furthermore, it can prevent ROCK-mediated migration, invasion, and anchorage-independent growth of MDA-MB-231 breast cancer cells (IC50 = 709 nM).

Uses

RKI-1447 is a potent and selective ROCK1 and ROCK2 inhibitor with significant anti-invasive and anti-tumor activies.

RKI1447 Preparation Products And Raw materials

Raw materials

Preparation Products

RKI1447 Suppliers

Global( 105)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6257 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6100 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32951 60 Inquiry
career henan chemical co +86-0371-86658258 +8613203830695 China 29884 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 32080 58 Inquiry
Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 22883 58 Inquiry
Zhejiang J&C Biological Technology Co.,Limited +1-2135480471 +1-2135480471 China 10473 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6391 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24727 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
career henan chemical co 58
BOC Sciences 58
TargetMol Chemicals Inc. 58
Dideu Industries Group Limited 58
Zhejiang J&C Biological Technology Co.,Limited 58
InvivoChem 58
LEAP CHEM CO., LTD. 58

RKI1447 Spectrum

RKI1447(1342278-01-6)1HNMR

1342278-01-6(RKI1447)Related Search:

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RKI1447 1-(3-HYDROXYBENZYL)-3-(4-(PYRIDIN-4-YL)THIAZOL-2-YL)UREA Urea, N-[(3-hydroxyphenyl)methyl]-N'-[4-(4-pyridinyl)-2-thiazolyl]- 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI 1447 RKI 1447 1-(3-Hydroxybenzyl)-3-[4-(pyridin-4-yl)thiazol-2-yl]urea RKI-1447, >=98% CS-855 RKI 1447; RKI1447 RKI-1447, 98%, a potent small molecule inhibitor of ROCK1 and ROCK2 1-[(3-hydroxyphenyl)methyl]-3-(4-pyridin-4-yl-1,3-thiazol-2-yl)urea RKI1447 USP/EP/BP 7-Pentahydroxyflavone RKI 1447 RKI-1447 1342278-01-6 Inhibitors