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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Structure
CAS No.
946387-07-1
Chemical Name:
2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide
Synonyms
PM-0016;RN 1734;TRPV4 Antagonist I, RN-1734;TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem;2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide;2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide;RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide);2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734);2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide;Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]-
CBNumber:
CB11529521
Molecular Formula:
C14H22Cl2N2O2S
Molecular Weight:
353.31
MOL File:
946387-07-1.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59
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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Properties

storage temp. 2-8°C
solubility DMSO: >20mg/mL
form Yellow solid
color white to off-white

SAFETY

Risk and Safety Statements

WGK Germany  nwg

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) R0658 RN-1734 ≥98% (HPLC) 946387-07-1 5MG ₹8746.6 2022-06-14 Buy
Sigma-Aldrich(India) R0658 RN-1734 ≥98% (HPLC) 946387-07-1 25MG ₹33860.6 2022-06-14 Buy
Sigma-Aldrich(India) 616520 TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem The TRPV4 Antagonist I, RN-1734, also referenced under CAS 946387-07-1, controls the biological activity of TRPV4. This small molecule/inhibitor is pr 946387-07-1 10MG ₹9380 2022-06-14 Buy
Product number Packaging Price Buy
R0658 5MG ₹8746.6 Buy
R0658 25MG ₹33860.6 Buy
616520 10MG ₹9380 Buy

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Chemical Properties,Uses,Production

Uses

RN 1734 is a novel TRPV4 modulator.

General Description

A cell-permeable benzenesulfonamide compound that acts as a selective TRPV4 antagonist and inhibits TRPV4 agonist 4α-PDD- (Cat. No. 524394) stimulated Ca2+ influx (IC50 = 2.3, 3.2 and 5.9 μM, respectively, in HEK293 expressing human, rat, or mouse TRPV4) without affecting the activity of three other human TRP (transient receptor potential) channels, including capsaicin- (Cat. No. 211275) activated TRPV1, camphor-activated TRPV3, and methanol-activated TRPM8 (IC50 >30 μM).

Biological Activity

Selective TRPV4 antagonist (IC 50 values are 2.3, 5.9 and 3.2 μ M for hTRPV4, mTRPV4 and rTRPV4 receptors respectively). Displays selectivity for over other TRP channels (IC 50 values are 2.3, >30, >30 and >100 μ M for TRPV4, TRPV3, TRPM8 and TRPV1 respectively).

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Preparation Products And Raw materials

Raw materials

Preparation Products

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Suppliers

Global( 74)Suppliers
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A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
ATK CHEMICAL COMPANY LIMITED +undefined-21-51877795 China 32836 60 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
LEAP CHEM CO., LTD. +86-852-30606658 China 24738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
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Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
SHANGHAI KEAN TECHNOLOGY CO., LTD. +8613817748580 China 40067 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
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Supplier Advantage
A.J Chemicals 58
ATK CHEMICAL COMPANY LIMITED 60
Career Henan Chemica Co 58
LEAP CHEM CO., LTD. 58
TargetMol Chemicals Inc. 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58
Aladdin Scientific 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 58
Amadis Chemical Company Limited 58
Shanghai Machine Pure Industrial Co., Ltd. 58

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide Spectrum

2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide(946387-07-1)1HNMR

946387-07-1(2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide)Related Search:

5-METHYL-N,N-DIMETHYLTRYPTAMINE Cumene N-Isopropylacrylamide N-Isopropylbenzylamine N-Methyl-2-pyrrolidone
RN-1 (hydrochloride) RKI1447 RN486
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2,4-dichloro-N-isopropyl-N-[2-(isopropylamino)ethyl]benzenesulfonamide RN 1734 2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulphonamide (RN-1734) 2,4-Dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]benzenesulfonamide TRPV4 Antagonist I, RN-1734 TRPV4 Antagonist I, RN-1734 - CAS 946387-07-1 - Calbiochem 2,4-dichloro-N-propan-2-yl-N-[2-(propan-2-ylamino)ethyl]benzenesulfonamide Benzenesulfonamide, 2,4-dichloro-N-(1-methylethyl)-N-[2-[(1-methylethyl)amino]ethyl]- RN-1734 (2,4-Dichloro-N-isopropyl-N-(2-isopropylaminoethyl)benzenesulfonamide) PM-0016 RN1734,Inhibitor,RN-1734,Transient receptor potential channels,TRP Channel,inhibit,RN 1734 946387-07-1