SULFAMETHIZOLE
- CAS No.
- 144-82-1
- Chemical Name:
- SULFAMETHIZOLE
- Synonyms
- SULFAMETHIZOL;thiosulfil;SULFAMETHIAZOLE;uroz;famet;rufol;VK 53;rp2145;Urifon;Urolin
- CBNumber:
- CB4266501
- Molecular Formula:
- C9H10N4O2S2
- Molecular Weight:
- 270.33
- MOL File:
- 144-82-1.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/4/24 21:50:42
| Melting point | 210 °C |
|---|---|
| Boiling point | 176°C (rough estimate) |
| Density | 1.4704 (rough estimate) |
| refractive index | 1.6440 (estimate) |
| storage temp. | 2-8°C |
| solubility | Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 5.45(at 25℃) |
| color | White to Off-White |
| Water Solubility | 529mg/L(20 ºC) |
| Merck | 14,8916 |
| BRN | 255002 |
| CAS DataBase Reference | 144-82-1(CAS DataBase Reference) |
| EPA Substance Registry System | Sulfamethizole (144-82-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H317 | |||||||||
| Precautionary statements | P280 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 43 | |||||||||
| Safety Statements | 36/37 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | WP0875000 | |||||||||
| HS Code | 2935904000 | |||||||||
| Hazardous Substances Data | 144-82-1(Hazardous Substances Data) | |||||||||
| Toxicity | LD50 oral in rat: 3500mg/kg | |||||||||
| NFPA 704 |
|
SULFAMETHIZOLE price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | S5632 | Sulfamethizole analytical standard, ≥99% (HPLC) | 144-82-1 | 10G | ₹7187.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | S5632 | Sulfamethizole analytical standard, ≥99% (HPLC) | 144-82-1 | 25G | ₹11009.03 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 46842 | Sulfamethizole VETRANAL?, analytical standard | 144-82-1 | 250MG | ₹5011.98 | 2022-06-14 | Buy |
| TCI Chemicals (India) | S0360 | Sulfamethizole | 144-82-1 | 25G | ₹5900 | 2022-05-26 | Buy |
SULFAMETHIZOLE Chemical Properties,Uses,Production
Description
Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC90s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae). It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.
Uses
Sulfamethizole is a sulfonamide based antibiotic that exhibit bactericidal activities towards gram-negative bacteria. Sulfamehizole was shown to be effective in treating gram-negative Bacillus AmpC en zyme in elderly patients with lower respiratory tract infection and as well as against microbs responsible for tuberculosis.
Definition
ChEBI: A sulfonamide consisting of a 1,3,4-thiadiazole nucleus with a methyl substituent at C-5 and a 4-aminobenzenesulfonamido group at C-2.
World Health Organization (WHO)
Sulfamethizole, a sulfonamide anti-infective agent, was introduced in 1953 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. However sulfamethizole, which is rapidly eliminated, retains a place in the treatment of urinary infections in some countries whereas in others its use has been discontinued.
General Description
Sulfamethizole’splasma half-life is 2.5 hours. This compound is a white crystallinepowder soluble 1:2,000 in water.
Air & Water Reactions
Insoluble in water.
Fire Hazard
Flammability data is lacking for SULFAMETHIZOLE. SULFAMETHIZOLE is probably non-flammable.
Pharmaceutical Applications
2-Sulfanilamido-5-methyl-1,3,4-thiodiazole. A short-acting sulfonamide (plasma half-life 2.5 h). Protein binding is c. 85%. About 60% is excreted in the urine within 5 h. It was formerly widely used in the treatment of urinary tract infection.
SULFAMETHIZOLE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Valens Molecules | +91-040-23417926 +91-4023417926 | Hyderabad, India | 10 | 58 | Inquiry |
| Dy - Mach Pharma | +91-2265018321 +91-2226833227 | Maharashtra, India | 18 | 58 | Inquiry |
| Ralington Pharma | +91-7948911722 +91-9687771722 | Gujarat, India | 1350 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3887 | 58 | Inquiry |
| Pharma Affiliates | 172-5066494 | Haryana, India | 6754 | 58 | Inquiry |
| Royal Trading Corporation | 07506059883 | Mumbai, India | 135 | 58 | Inquiry |
| Index Pharma | 68.00070459 | Maharashtra, India | 12 | 58 | Inquiry |
| Mesha Pharma Private Limited | 08048372569Ext 806 | Mumbai, India | 133 | 58 | Inquiry |
| Hritik Chemical Corporation | +91-22-6692 5779 | Mumbai, India | 55 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Valens Molecules | 58 |
| Dy - Mach Pharma | 58 |
| Ralington Pharma | 58 |
| Clearsynth Labs | 58 |
| Pharma Affiliates | 58 |
| Royal Trading Corporation | 58 |
| Index Pharma | 58 |
| Mesha Pharma Private Limited | 58 |
| Hritik Chemical Corporation | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
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