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SULFAMETHIZOLE

CAS No.: 144-82-1

Chemical Name:: SULFAMETHIZOLE

Synonyms: SULFAMETHIZOL;thiosulfil;SULFAMETHIAZOLE;uroz;famet;rufol;VK 53;rp2145;Urifon;Urolin

CBNumber:: CB4266501

Molecular Formula:: C9H10N4O2S2

Molecular Weight:: 270.33

MOL File:: 144-82-1.mol

MSDS File:: SDS

Modify Date:: 2024/7/2 8:55:08

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SULFAMETHIZOLE Properties

Melting point	210 °C
Boiling point	176°C (rough estimate)
Density	1.4704 (rough estimate)
refractive index	1.6440 (estimate)
storage temp.	2-8°C
solubility	Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	5.45(at 25℃)
color	White to Off-White
Water Solubility	529mg/L(20 ºC)
Merck	14,8916
BRN	255002
CAS DataBase Reference	144-82-1(CAS DataBase Reference)
EPA Substance Registry System	Sulfamethizole (144-82-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H317

Precautionary statements

P280

Hazard Codes

Risk Statements

Safety Statements

36/37

WGK Germany

RTECS

WP0875000

HS Code

2935904000

Toxicity

LD50 oral in rat: 3500mg/kg

NFPA 704

	0
2		0

SULFAMETHIZOLE price More Price(4)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	S5632	Sulfamethizole analytical standard, ≥99% (HPLC)	144-82-1	10G	₹7187.8	2022-06-14	Buy
Sigma-Aldrich(India)	S5632	Sulfamethizole analytical standard, ≥99% (HPLC)	144-82-1	25G	₹11009.03	2022-06-14	Buy
Sigma-Aldrich(India)	46842	Sulfamethizole VETRANAL?, analytical standard	144-82-1	250MG	₹5011.98	2022-06-14	Buy
TCI Chemicals (India)	S0360	Sulfamethizole	144-82-1	25G	₹5900	2022-05-26	Buy

Product number	Packaging	Price	Buy
S5632	10G	₹7187.8	Buy
S5632	25G	₹11009.03	Buy
46842	250MG	₹5011.98	Buy
S0360	25G	₹5900	Buy

SULFAMETHIZOLE Chemical Properties,Uses,Production

Description

Sulfamethizole is a broad spectrum sulfonamide antibiotic (MIC₉₀s = 1.25-5,000 μg/ml against clinical isolates of E. coli and K. pneumoniae). It inhibits dihydropteroate synthase, an enzyme involved in folate biosynthesis. Formulations containing sulfamethizole have previously been used to treat urinary tract infections.

Uses

Sulfamethizole is a sulfonamide based antibiotic that exhibit bactericidal activities towards gram-negative bacteria. Sulfamehizole was shown to be effective in treating gram-negative Bacillus AmpC en zyme in elderly patients with lower respiratory tract infection and as well as against microbs responsible for tuberculosis.

Definition

ChEBI: A sulfonamide consisting of a 1,3,4-thiadiazole nucleus with a methyl substituent at C-5 and a 4-aminobenzenesulfonamido group at C-2.

World Health Organization (WHO)

Sulfamethizole, a sulfonamide anti-infective agent, was introduced in 1953 for the treatment of bacterial infections. The importance of sulfonamides has subsequently decreased as a result of increasing bacterial resistance and their replacement by antibiotics which are generally more active and less toxic. However sulfamethizole, which is rapidly eliminated, retains a place in the treatment of urinary infections in some countries whereas in others its use has been discontinued.

General Description

Sulfamethizole’splasma half-life is 2.5 hours. This compound is a white crystallinepowder soluble 1:2,000 in water.

Air & Water Reactions

Insoluble in water.

Fire Hazard

Flammability data is lacking for SULFAMETHIZOLE. SULFAMETHIZOLE is probably non-flammable.

Pharmaceutical Applications

2-Sulfanilamido-5-methyl-1,3,4-thiodiazole. A short-acting sulfonamide (plasma half-life 2.5 h). Protein binding is c. 85%. About 60% is excreted in the urine within 5 h. It was formerly widely used in the treatment of urinary tract infection.

SULFAMETHIZOLE Preparation Products And Raw materials

Raw materials

(1E)-3-amino-1-ethylidene-thiourea

Preparation Products

SULFAMETHIZOLE Suppliers

Global( 213)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Ralington Pharma	+91-7948911722 +91-9687771722	Gujarat, India	1350	58	Inquiry
Valens Molecules	+91-040-23417926 +91-4023417926	Hyderabad, India	10	58	Inquiry
Dy - Mach Pharma	+91-2265018321 +91-2226833227	Maharashtra, India	18	58	Inquiry
VALENS MOLECULES PRIVATE LIMITED	+91 40 2341 7926	New Delhi, India	2	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Dolace Solutions Private Limited	91--9890007892	Maharashtra, India	240	58	Inquiry
Ken Pharma	91-22-66778954	Maharashtra, India	84	58	Inquiry

Supplier	Advantage
Ralington Pharma	58
Valens Molecules	58
Dy - Mach Pharma	58
VALENS MOLECULES PRIVATE LIMITED	58
TCI Chemicals (India) Pvt. Ltd.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Dolace Solutions Private Limited	58
Ken Pharma	58

SULFAMETHIZOLE Spectrum

SULFAMETHIZOLE(144-82-1)MS SULFAMETHIZOLE(144-82-1)¹HNMR SULFAMETHIZOLE(144-82-1)¹³CNMR SULFAMETHIZOLE(144-82-1)IR1 SULFAMETHIZOLE(144-82-1)IR2

144-82-1(SULFAMETHIZOLE)Related Search:

TERT-BUTYL 4-(AMINOCARBONYL)TETRAHYDROPYRIDINE-1(2H)-CARBOXYLATE SULFAMETHIZOLE 4-AMINO-N-(5-ETHYL-[1,3,4]THIADIAZOL-2-YL)-BENZENESULFONAMIDE 1-Boc-4-(aminomethyl)piperidine tert-Butyl 4-(aminocarbothioyl)tetrahydropyridine-1(2H)-carboxylate

Sulfanilamide BOC-3-CARBOXYMETHYL-1-PHENYL-1,3,8-TRIAZASPIRO[4 5]DECAN-4-ONE 4-(AMINO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER (S)-A-FMOC-D-BOC-4-PIPERIDYLGLYCINE 1-BOC-4-(AMINOCARBOXYMETHYL)PIPERIDINE

glybuthiazol 1-T-BOC-PIPERIDINE-4-SPIRO-5'-[1',3'-BIS-T-BOC]-HYDANTOIN N-(TERT-BUTOXYCARBONYL)PIPERIDIN-4-YLMETHYLPIPERIDINE-4-CARBOXYLIC ACID (R)-N-ALPHA-(9-FLUORENYLMETHYLOXYCARBONYL)-N'-T-BUTYLOXYCARBONYL-4-PIPERIDYLGLYCINE Phthalylsulfamethizol

(S)-4-(AMINO-METHOXYCARBONYL-METHYL)-PIPERIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 3-[4-(5-ETHYL-[1,3,4]THIADIAZOL-2-YLSULFAMOYL)-PHENYLCARBAMOYL]-ACRYLIC ACID SULFAETHIDOLE SODIUM

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ayerlucil famet lucosil methazol microsul n(1)-(5-methyl-1,3,4-thiadiazol-2-yl)-sulfanilamid n(sup1)-(5-methyl-1,3,4-thiadiazol-2-yl)-sulfanilamid n(sup1)-(5-methyl-1,3,4-thiadiazol-2-yl)-sulfanilamide renasul rp2145 rufol salimol sulfagram sulfamethylizole sulfapyelon sulfstat sulfurine tetracid thidicur ultrasul urocydal urodiaton urolucosil urosulfin uroz utrasul N1-(5-methyl-1,3,4-thiadiazol-2-yl)sulphanilamide Sulamethizole SULFAMETHIZOLE VETRANAL, 250 MG 4-AMINO-N-[5-METHYL-1,3,4-THIADIAZOL-2-YL]-BENZENESULFONAMIDE Sulfamethizole Solution, 100ppm 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide, N1-(5-Methyl-1,3,4-thiadiazol-2-yl)sulfanilamide Urifon Urolin VK 53 4-Amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzene-1-sulfonamide 4-azanyl-N-(5-methyl-1,3,4-thiadiazol-2-yl)benzenesulfonamide Sulfamethizole (200 mg) LABOTEST-BB LT00772293 SULFAMETHYLTHIADIAZOLE SULFAMETHIZOLE SULPHAMETHIZOLE N1-(5-METHYL-1,3,4-THIADIAZOL-2-YL)SULFANILAMIDE Sulfamethizole solution,1000ppm SULPHAMETHIAZOLE 2-(p-aminobenzenesulfonamido)-5-methylthiadiazole 2-methyl-5-sulfanilamido-1,3,4-thiadiazole 2-sulfanilamido-5-methyl-1,3,4-thiadiazole 4-amino-n-(5-methyl-1,3,4-thiadiazol-2-yl)-benzenesulfonamid 5-methyl-2-sulfanilamido-1,3,4-thiadiazole Sulfamethizole CRS Sulfamethizole> Benzenesulfonamide, 4-amino-N-(5-methyl-1,3,4-thiadiazol-2-yl)- SULFAMETHIZOLE USP/EP/BP Sulfamethizole (1630009) thiosulfil SULFAMETHIAZOLE SULFAMETHIZOL