N-Methyl-N-(trimethylsilyl)acetamide
- CAS No.
- 7449-74-3
- Chemical Name:
- N-Methyl-N-(trimethylsilyl)acetamide
- Synonyms
- N-METHYL-N-TRIMETHYLSILYLACETAMIDE;MOUSE ALBUMIN;N-Methyl-N-TMS-acetamide;[TriMethylsilylating Agent];N-METHYL-N-TRIMETHYLSILYACETAMIDE;N-TRIMETHYLSILYL-N-METHYLACETAMIDE;N-Methyl-N-trimethylsilylacetamine;n-methyl-n-(trimethylsilyl)-acetamid;MSA~N-Trimethylsilyl-N-methylacetamide;Acetamide,N-methyl-N-(trimethylsilyl)-
- CBNumber:
- CB4355232
- Molecular Formula:
- C6H15NOSi
- Molecular Weight:
- 145.27
- MOL File:
- 7449-74-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/9/3 10:43:34
| Boiling point | 159-161 °C(lit.) |
|---|---|
| Density | 0.904 g/mL at 20 °C(lit.) |
| refractive index |
n |
| Flash point | 48 °C |
| storage temp. | -20°C |
| form | lyophilized powder |
| pka | -0.11±0.70(Predicted) |
| color | Clear light yellow |
| Specific Gravity | 0.906 |
| Sensitive | Moisture Sensitive |
| BRN | 506975 |
| InChI | InChI=1S/C6H15NOSi/c1-6(8)7(2)9(3,4)5/h1-5H3 |
| InChIKey | QHUOBLDKFGCVCG-UHFFFAOYSA-N |
| SMILES | C(N(C)[Si](C)(C)C)(=O)C |
| CAS DataBase Reference | 7449-74-3(CAS DataBase Reference) |
| NIST Chemistry Reference | Acetamide, n-methyl-n-(trimethylsilyl)-(7449-74-3) |
| EPA Substance Registry System | Acetamide, N-methyl-N-(trimethylsilyl)- (7449-74-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H314-H315-H319-H335-H226 | |||||||||
| Precautionary statements | P261-P303+P361+P353-P305+P351+P338-P501a-P210-P233-P240-P241+P242+P243-P260-P264-P280-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P370+P378-P403+P235-P405-P501 | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 10-36/37/38 | |||||||||
| Safety Statements | 37/39-16 | |||||||||
| RIDADR | UN 1993 3/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 3 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
N-Methyl-N-(trimethylsilyl)acetamide price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 69480 | N-Methyl-N-trimethylsilylacetamide for GC derivatization, LiChropur?, ≥97.0% (GC) | 7449-74-3 | 10ML | ₹20892.25 | 2022-06-14 | Buy |
| TCI Chemicals (India) | M0536 | N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] min. 90.0 % | 7449-74-3 | 10G | ₹5600 | 2022-05-26 | Buy |
| TCI Chemicals (India) | M0536 | N-Methyl-N-trimethylsilylacetamide [Trimethylsilylating Agent] min. 90.0 % | 7449-74-3 | 25G | ₹9500 | 2022-05-26 | Buy |
| ALFA India | ALF-L04101-09 | N-Methyl-N-trimethylsilylacetamide, 98% | 7449-74-3 | 10g | ₹4811 | 2022-05-26 | Buy |
| ALFA India | ALF-L04101-04 | N-Methyl-N-trimethylsilylacetamide, 98% | 7449-74-3 | 2g | ₹3407 | 2022-05-26 | Buy |
N-Methyl-N-(trimethylsilyl)acetamide Chemical Properties,Uses,Production
Chemical Properties
clear light yellow liquid
Uses
N-Methyl-N-trimethylsilylacetamide may be used as a derivatizing reagent for the following:
- Quantification of the carbohydrate intermediates in glycation systems using gas chromatography coupled to mass spectrometry technique.
- Characterization of damaged products of thymine and cytosine formed by the exposure to UV light in a hydrogen peroxide solution using gas chromatography/mass spectrometry with scan mode and selected ion monitoring mode.
Reactions
The interaction of N-Methyl-N-(trimethylsilyl)acetamide with chloromethyl(methyl)-diacetoxysilane led to the formation of 2,4,6-trimethyl-2,4-bis((N-methylacetamido)methyl)-1,3,5,2,4-trioxadisilinan-6-ylium chloride[1].
General Description
N-Methyl-N-trimethylsilylacetamide is a trialkyl-silyl reagent and a versatile derivatizing agent used in gas chromatography (GC).
Purification Methods
N-Methyl-N-trimethylsilylacetamide [7449-74-3] M 145.3, b 48 -49o/11mm, 8 4o/13mm, 105-107o/35mm (solid at room temperature), d 4 0.90, n D 1.4379. A likely impurity is Et3N.HCl which can be detected by its odour. If it is completely soluble in *C6H6, then redistil; otherwise dissolve it in this solvent, filter and evaporate first in a vacuum at 12mm, then fractionate; all operations should be carried out in a dry N2 atmosphere. [Klebe et al. J Am Chem Soc 88 3390 1966, Ried & Suarez-Rivero Chem Ber 96 1473 1963, Beilstein 4 IV 4011.]
References
[1] Nataliya F. Lazareva, Igor M.Lazarev,lrina V.Sterkhova. "Trans-silylationof N-methyl-N-trimethylsilylacetamide with chloromethyl(methyl)diacetoxysilane."Journal of Organometallic Chemistry1006 (2023): Article 123000.
N-Methyl-N-(trimethylsilyl)acetamide Preparation Products And Raw materials
Global( 155)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Kalintis Healthcare Pvt Ltd | +91-7069089302 +91-7069089302 | Gujarat, India | 12 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Kalintis Healthcare Pvt. Ltd. | 91-2667-290770 | Gujarat, India | 11 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7621 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29824 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +8618949823763 | China | 34571 | 58 | Inquiry |
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N-METHYL-N-TRIMETHYLSILYLACETAMIDE
7449-74-3
C6H15NOSi
Si (Classes of Silicon Compounds)
Silylacetamides
Si-N Compounds
Silylation (GC Derivatizing Reagents)
Trimethylsilylation (GC Derivatizing Reagents)
GC Derivatizing Reagents
Derivatization Reagents
Fluka Reagents
Analytical Chromatography Product Catalog
Analytical Chemistry
GC Derivatizing Reagents
Si (Classes of Silicon Compounds)
Silylacetamides
Silylation (GC Derivatizing Reagents)
Si-N Compounds
Trimethylsilylation (GC Derivatizing Reagents)