1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE
![1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE Structure](CAS/GIF/91166-50-6.gif)
- CAS No.
- 91166-50-6
- Chemical Name:
- 1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE
- Synonyms
- DK424;BIS(DIMETHYLAMINODIMETHYLSILYL)ETHANE;1,2-bis((diethylamino)dimethylsilyl)ethane;1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE;α,α'-Ethylenebis(N,N,α,α-tetramethylsilanamine);1,1'-ETHYLENEBIS(N,N,1,1-TETRAMETHYLSILANAMINE);1,1'-ETHYLENEBIS(N,N,1,1-TETRAMETHYLSILANAMIDE);[Protecting Reagent for Aromatic Primary Amines];1,2-Bis[(dimethylamino)dimethylsilyl]ethane 2,5-Bis(dimethylamino)-2,5-dimethyl-2,5-disilahexane
- CBNumber:
- CB4429063
- Molecular Formula:
- C10H28N2Si2
- Molecular Weight:
- 232.51
- MOL File:
- 91166-50-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/2 17:35:04
| Boiling point | 101-103 °C13 mm Hg(lit.) |
|---|---|
| Density | 0.824 g/mL at 25 °C(lit.) |
| refractive index |
n |
| Flash point | 57 °F |
| pka | 10.31±0.70(Predicted) |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 0.824 |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| BRN | 4366167 |
| CAS DataBase Reference | 91166-50-6(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H314 | |||||||||
| Precautionary statements | P233-P240-P241+P242+P243-P260-P264-P301+P330+P331+P310-P303+P361+P353+P310+P363-P304+P340+P310-P305+P351+P338+P310-P403+P235-P405-P501-P210-P280-P305+P351+P338-P310 | |||||||||
| Hazard Codes | F,C | |||||||||
| Risk Statements | 11-34 | |||||||||
| Safety Statements | 16-26-36/37/39-45 | |||||||||
| RIDADR | UN 2924 3/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | No | |||||||||
| HazardClass | 3.1 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29319019 | |||||||||
| NFPA 704 |
|
1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE price More Price(1)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemicals (India) | B1773 | 1,2-Bis[(dimethylamino)dimethylsilyl]ethane [Protecting Reagent for Aromatic Primary Amines] min. 93.0 % | 91166-50-6 | 5G | ₹15400 | 2022-05-26 | Buy |
| Product number | Packaging | Price | Buy |
|---|---|---|---|
| B1773 | 5G | ₹15400 | Buy |
1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE Chemical Properties,Uses,Production
Physical properties
bp 100–103°C/13 mmHg; d 0.824 g cm?3.
Uses
1,4-Bis(dimethylamino)-1,1,4,4-tetramethyldisilethylene is used as a reagent for the protection of primary amines with lower pKa
values, such as substituted anilines, as their tetramethyldisilylazacyclopentane
or Stabase adduct; precursor of tetramethyldisilylthiacyclopentane,
a sulfur transfer reagent.
The title reagent
is used for the preparation of Stabase derivatives of primary
amines, and is particularly useful for the protection of primary
aromatic amines with pKa values of 10–11. The protection of
substituted anilines is achieved by heating equimolar amounts of
the title compound and the anilines in the presence of zinc iodide
(0.5 mol %) under a slow stream of nitrogen at 140°C for 5 h. In
many cases the products can be purified by vacuum distillation.
Cleavage of the Stabase adducts to the corresponding primary
amines can be performed in ether in the presence of 2 equiv of
methanol and a small amount of p-toluenesulfonic acid monohydrate
(0.2 mol %). The tetramethyldisilylazacyclopentane or
Stabase adduct (3) is a particularly attractive protecting group due
to its ease of preparation, base stability, and facile removal (eq 1).
Preparation
the reagent is prepared as a colorless liquid in 90% yield by treating commercially available bis(chlorodimethylsilyl) ethane with 5 equiv of dimethylamine in ether at 0°C for 5 h.
storage
The liquid vapors are heavier than air and may travel a considerable distance to a source of ignition. Vapor-air mixtures are explosive above the flash point of 14 °C. Use in a fume hood.
1,2-BIS[(DIMETHYLAMINO)DIMETHYLSILYL]ETHANE Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6768 | 58 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | China | 19805 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 33024 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29858 | 58 | Inquiry |
| Win-Win chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | China | 14442 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | +86-0571-88938639 +8617705817739 | China | 52849 | 58 | Inquiry |
| Alfa Chemistry | United States | 24072 | 58 | Inquiry | |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | China | 9984 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | China | 20235 | 58 | Inquiry |
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