1,2-Bis(chlorodimethylsilyl)ethane
- CAS No.
- 13528-93-3
- Chemical Name:
- 1,2-Bis(chlorodimethylsilyl)ethane
- Synonyms
- 1,2-Bis(chlorodimethylsilyl);1,1,4,4-TETRAMETHYL-1,4-DICHLORODISILYLETHYLENE;chloro[2-(chlorodimethylsilyl)ethyl]dimethylsilane;DK065;DK525;STABASE;SILANE BM2E;[-CH2Si(CH3)2Cl]2;Patchouli oil 8014-09-3;1,2-Bis(dimethylchlorosily)ethane
- CBNumber:
- CB6154680
- Molecular Formula:
- C6H16Cl2Si2
- Molecular Weight:
- 215.27
- MOL File:
- 13528-93-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/4/23 13:52:06
| Melting point | 35-38 °C (lit.) |
|---|---|
| Boiling point | 198 °C/734 mmHg (lit.) |
| Density | 0.99 |
| Flash point | 155 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | Low Melting Solid |
| color | Transparent |
| Water Solubility | Reacts with water. |
| Sensitive | Moisture Sensitive |
| Hydrolytic Sensitivity | 8: reacts rapidly with moisture, water, protic solvents |
| BRN | 1920141 |
| InChIKey | VGQOKOYKFDUPPJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 13528-93-3(CAS DataBase Reference) |
| EPA Substance Registry System | Silane, 1,2-ethanediylbis[chlorodimethyl- (13528-93-3) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H314 | |||||||||
| Precautionary statements | P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P363 | |||||||||
| Hazard Codes | C | |||||||||
| Risk Statements | 34-10 | |||||||||
| Safety Statements | 26-28-36/37/39-45-16 | |||||||||
| RIDADR | UN 3261 8/PG 2 | |||||||||
| WGK Germany | 3 | |||||||||
| F | 10-21 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29319000 | |||||||||
| NFPA 704 |
|
1,2-Bis(chlorodimethylsilyl)ethane price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 267880 | 1,2-Bis(chlorodimethylsilyl)ethane 96% | 13528-93-3 | 25G | ₹3220 | 2022-06-14 | Buy |
| ALFA India | ALF-L02570-22 | 1,2-Bis(chlorodimethylsilyl)ethane, tech. 90% | 13528-93-3 | 100g | ₹13480 | 2022-05-26 | Buy |
| ALFA India | ALF-L02570-14 | 1,2-Bis(chlorodimethylsilyl)ethane, tech. 90% | 13528-93-3 | 25g | ₹2870 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B1688 | 1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines] min. 95.0 % | 13528-93-3 | 5G | ₹3300 | 2022-05-26 | Buy |
| TCI Chemicals (India) | B1688 | 1,2-Bis(chlorodimethylsilyl)ethane [Protecting Reagent for Primary Amines] min. 95.0 % | 13528-93-3 | 25G | ₹9500 | 2022-05-26 | Buy |
1,2-Bis(chlorodimethylsilyl)ethane Chemical Properties,Uses,Production
Chemical Properties
transparent low melting solid
Physical properties
mp 36–41°C; bp 198°C/734 mmHg.
Uses
1,2-Bis(chlorodimethylsilyl)ethane can be used as a reagent for the protection of primary amines as their tetramethyldisilylazacyclopentane
or Stabase adducts; used in combination
with zinc to form organozinc carbenoids; electrophilic silylating
reagent.
Protection of Primary Amines.
Few protecting groups exist
for the N,N-diprotection of primary amines. The tetramethyldisilylazacyclopentane
or Stabase adduct (3) is particularly attractive
for this purpose due to its ease of preparation, base stability and
facile removal. This cyclic disilane is easily prepared (eq 1) from
the commercially available title reagent (1).For primary amines
with pKa values between 10 and 11, typical reaction conditions
involve the treatment of a dichloromethane solution of the amine
with (1) in the presence of two equivalents of triethylamine at
room temperature. Subsequent workup with aqueous dihydrogen
phosphate provides (3) in excellent yields.1 Stabase adducts are
quite stable to strongly basic conditions such as n-butyllithium and
s-butyllithium (at ?25°C), lithium diisopropylamide, and Grignard
reagents making it a superb candidate for use in the alkylation
of substrates bearing a primary amine. For example, protected
amino acid derivatives are easily alkylated (eq 2).After formation
of the lithium enolate of the protected ethyl glycinate (4)
under standard conditions, exposure to various alkyl halides or
aldehydes yields alkylation products such as (5).
1,2-Bis(chlorodimethylsilyl)ethane Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | China | 29797 | 60 | Inquiry |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | China | 16221 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32715 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 15093356674; | China | 29902 | 58 | Inquiry |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 | China | 2995 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| CLEARSYNTH LABS LTD. | 58 |
| A.J Chemicals | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
| Clearsynth Labs | 58 |
| Capot Chemical Co.,Ltd. | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | 58 |
| ATK CHEMICAL COMPANY LIMITED | 60 |
| career henan chemical co | 58 |
| Xi'an Kono chem co., Ltd., | 58 |
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