1,2-Bis(chlorodimethylsilyl)ethane

1,2-Bis(chlorodimethylsilyl)ethane 구조식 이미지
카스 번호:
13528-93-3
상품명:
1,2-Bis(chlorodimethylsilyl)ethane
동의어(영문):
1,2-Bis(chlorodimethylsilyl);1,1,4,4-TETRAMETHYL-1,4-DICHLORODISILYLETHYLENE;chloro[2-(chlorodimethylsilyl)ethyl]dimethylsilane;DK065;DK525;STABASE;SILANE BM2E;[-CH2Si(CH3)2Cl]2;Patchouli oil 8014-09-3;1,2-Bis(dimethylchlorosily)ethane
CBNumber:
CB6154680
분자식:
C6H16Cl2Si2
포뮬러 무게:
215.27
MOL 파일:
13528-93-3.mol
MSDS 파일:
SDS

1,2-Bis(chlorodimethylsilyl)ethane 속성

녹는점
35-38 °C (lit.)
끓는 점
198 °C/734 mmHg (lit.)
밀도
0.99
인화점
155 °F
저장 조건
Inert atmosphere,Room Temperature
물리적 상태
저융점 고체
색상
투명한
수용성
물과 반응합니다.
감도
Moisture Sensitive
Hydrolytic Sensitivity
8: reacts rapidly with moisture, water, protic solvents
BRN
1920141
InChIKey
VGQOKOYKFDUPPJ-UHFFFAOYSA-N
CAS 데이터베이스
13528-93-3(CAS DataBase Reference)
EPA
Silane, 1,2-ethanediylbis[chlorodimethyl- (13528-93-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 C
위험 카페고리 넘버 34-10
안전지침서 26-28-36/37/39-45-16
유엔번호(UN No.) UN 3261 8/PG 2
WGK 독일 3
F 고인화성물질 10-21
TSCA Yes
위험 등급 8
포장분류 III
HS 번호 29319000
그림문자(GHS): GHS hazard pictograms
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
예방조치문구:
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P363 다시 사용전 오염된 의류는 세척하시오.
NFPA 704
1
3 0

1,2-Bis(chlorodimethylsilyl)ethane C화학적 특성, 용도, 생산

화학적 성질

transparent low melting solid

물리적 성질

mp 36–41°C; bp 198°C/734 mmHg.

용도

1,2-Bis(chlorodimethylsilyl)ethane can be used as a reagent for the protection of primary amines as their tetramethyldisilylazacyclopentane or Stabase adducts; used in combination with zinc to form organozinc carbenoids; electrophilic silylating reagent.
Protection of Primary Amines.
Few protecting groups exist for the N,N-diprotection of primary amines. The tetramethyldisilylazacyclopentane or Stabase adduct (3) is particularly attractive for this purpose due to its ease of preparation, base stability and facile removal. This cyclic disilane is easily prepared (eq 1) from the commercially available title reagent (1).For primary amines with pKa values between 10 and 11, typical reaction conditions involve the treatment of a dichloromethane solution of the amine with (1) in the presence of two equivalents of triethylamine at room temperature. Subsequent workup with aqueous dihydrogen phosphate provides (3) in excellent yields.1 Stabase adducts are quite stable to strongly basic conditions such as n-butyllithium and s-butyllithium (at ?25°C), lithium diisopropylamide, and Grignard reagents making it a superb candidate for use in the alkylation of substrates bearing a primary amine. For example, protected amino acid derivatives are easily alkylated (eq 2).After formation of the lithium enolate of the protected ethyl glycinate (4) under standard conditions, exposure to various alkyl halides or aldehydes yields alkylation products such as (5).Reactions of 1,2-Bis(chlorodimethylsilyl)ethane

1,2-Bis(chlorodimethylsilyl)ethane 준비 용품 및 원자재

원자재

준비 용품


1,2-Bis(chlorodimethylsilyl)ethane 공급 업체

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